2529891-44-7
Chemical Structure
EGFR-IN-59
- CAS 番号: 2529891-44-7
- Formula:C27H23N5O4S
- Molecular Weight:513.57
IUPAC Name: (E)-4-((2-(4-methoxystyryl)quinazolin-4-yl)amino)-N-(5-methylisoxazol-3-yl)benzenesulfonamide
InChIKey: BHPUGVPSLDRNDT-CXUHLZMHSA-N
SMILES: O=S(C1=CC=C(NC2=C3C=CC=CC3=NC(/C=C/C4=CC=C(OC)C=C4)=N2)C=C1)(NC5=NOC(C)=C5)=O
Biological Activity: EGFR-IN-59 (Compound 8c) is a EGFR inhibitor (IC50=190 nM) and apoptosis inducer. EGFR-IN-59 exhibits cytotoxicity against non-small lung cancer cell lines (A549) and normal lung fibroblasts (WI38) with IC50s of 8.62 and 52.6 µM, respectively. EGFR-IN-59 can be used for the research of various cancers such as non-small cell lung cancer (NSCLC), head and neck cancer, breast cancer and colorectal cancer[1].
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EGFR-IN-59 | EGFR-IN-59 (Compound 8c) is a EGFR inhibitor (IC50=190 nM) and apoptosis inducer. EGFR-IN-59 exhibits cytotoxicity against non-small lung cancer cell lines (A549) and normal lung fibroblasts (WI38) with IC50s of 8.62 and 52.6 µM, respectively. EGFR-IN-59 can be used for the research of various cancers such as non-small cell lung cancer (NSCLC), head and neck cancer, breast cancer and colorectal cancer. | |||||||||||||||||||||
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Keywords
