LMTK3-IN-1
Based on 1 publication(s) in Google Scholar
LMTK3-IN-1 is an ATP-competitive LMTK3 inhibitor with a Kd of 2.50 µM. LMTK3-IN-1 promotes LMTK3 degradation through the ubiquitin-proteasome pathway. LMTK3-IN-1 inhibits LMTK3 kinase activity and reduces LMTK3-dependent Rab7 phosphorylation. LMTK3-IN-1 induces apoptosis in breast cancer cells. LMTK3-IN-1 can be used for research on breast cancer.
For research use only. We do not sell to patients.
- Purity : 98.97%
- CAS No.: 2764850-23-7
- Formula: C18H11F3N4O
- Molecular Weight:356.30
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
-
HY-116000
Glumetinibc-Met Inhibitor -
HY-18696
AMG-337MET Kinase Inhibitor -
HY-114363A
SRI 31215 TFAMatriptase/Hepsin/HGFA Inhibitor -
HY-13299
MK-8033c-Met/Ron Inhibitor -
HY-100946
CEP-40783AXL/c-Met Inhibitor -
HY-16446
SAR125844MET Inhibitor -
HY-133083
BAY-474c-Met Inhibitor -
HY-14721
Tepotinibc-Met Inhibitor -
HY-16969
Dihexa -
HY-50683
JNJ-38877605c-Met/HGFR Inhibitor -
HY-12076
BMS 777607c-Met/Axl Inhibitor
Publications Citing Use of MedChemExpress (MCE) LMTK3-IN-1
More
Biological Activity
Description
IC50 & Target
[1]|
LMTK3 2.5 μM (Ki) |
In Vitro
LMTK3-IN-1 (10 μM) attenuates the M2-promoting and M1-inhibiting effects of EVs derived from LMTK3-overexpressing breast cancer cells on macrophages[2].
LMTK3-IN-1 inhibits 33 of 403 kinases with >90% inhibition in KINOMEscan profiling, with an S (35) selectivity index of 0.186[1].
LMTK3-IN-1 binds purified LMTK3 via MST with a Kd of 2.50 µM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MCF7 and T47D breast cancer cells
-
Concentration:10 µM
-
Incubation Time:72 h
-
Result:Induced apoptosis in MCF7 and T47D cells at 10 µM after 72 h.
Chemical Information
-
CAS No. 2764850-23-7
-
Appearance Solid
-
Molecular Weight 356.30
-
Formula C18H11F3N4O
-
Color Light yellow to yellow
-
SMILES
FC(F)(OC1=CC=CC(C2=CN=C3C=CC(C4=CC=NC=C4)=NN32)=C1)F
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
-
Journal Impact Factor
-
Most Recent
Solvent & Solubility
In Vitro:
DMSO : 5 mg/mL (14.03 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Purity & Documentation
-
Data Sheet (278 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
[1]. Agnarelli A, et al. The Inhibitory Properties of a Novel, Selective LMTK3 Kinase Inhibitor. Int J Mol Sci. 2023 Jan 3;24(1):865. [Content Brief]
[2]. Samuels M, et al. LMTK3 regulation of EV biogenesis and cargo sorting promotes tumour growth by reducing monocyte infiltration and driving pro-tumourigenic macrophage polarisation in breast cancer. Mol Cancer. 2025 May 23;24(1):149. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8066 mL | 14.0331 mL | 28.0662 mL | 70.1656 mL |
| 5 mM | 0.5613 mL | 2.8066 mL | 5.6132 mL | 14.0331 mL | |
| 10 mM | 0.2807 mL | 1.4033 mL | 2.8066 mL | 7.0166 mL |
LMTK3-IN-1 Related Classifications
HY-153896 Related Classifications
Powered by Bioz