2764850-23-7
2764850-23-7
Chemical Structure
LMTK3-IN-1
- CAS No.: 2764850-23-7
- Formula:C18H11F3N4O
- Molecular Weight:356.30
InChIKey: SFBZOJORTROAIE-UHFFFAOYSA-N
SMILES: FC(F)(OC1=CC=CC(C2=CN=C3C=CC(C4=CC=NC=C4)=NN32)=C1)F
Biological Activity: LMTK3-IN-1 (compound C28) is an ATP-competitive inhibitor of lemur tyrosine kinase 3 (LMTK3) (Kd=2.5 μM)，that acts by degrading LMTK3 via the ubiquitin-proteasome pathway. LMTK3-IN-1 shows anticancer activity in a variety of cancer cell lines and in vivo BC mouse models. LMTK3-IN-1 induces apoptosis in BC cell lines at 10-20 μM[1].
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LMTK3-IN-1 | 98.74% | LMTK3-IN-1 (compound C28) is an ATP-competitive inhibitor of lemur tyrosine kinase 3 (LMTK3) (Kd=2.5 μM)，that acts by degrading LMTK3 via the ubiquitin-proteasome pathway. LMTK3-IN-1 shows anticancer activity in a variety of cancer cell lines and in vivo BC mouse models. LMTK3-IN-1 induces apoptosis in BC cell lines at 10-20 μM. | ||||||||||||||||||||
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References
Keywords
