Search Result

Isoforms Recommended:	Bcl-2

Results for "

Bcl‐2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Bcl-2 Family (411) 5-HT Receptor (1) Acetyl-CoA Carboxylase (1) ACSL Family (1) Acyltransferase (1) ADAMTS (1) ADC Linker (1) Adenosine Receptor (1) Adrenergic Receptor (6) Akt (50) AMPK (8) Anaplastic lymphoma kinase (ALK) (1) Androgen Receptor (3) Antibiotic (3) Apoptosis (321) ASK1 (2) Atg8/LC3 (1) Aurora Kinase (1) Autophagy (41) Bacterial (23) Bcr-Abl (3) Beclin1 (2) Beta-secretase (2) Biochemical Assay Reagents (5) Bombesin Receptor (1) Btk (1) c-Met/HGFR (1) c-Myc (9) Cadherin (4) Calcium Channel (3) Cannabinoid Receptor (1) Carbonic Anhydrase (3) Carnitine Palmitoyltransferase (CPT) (1) Casein Kinase (2) Caspase (162) CaSR (1) CDK (25) Checkpoint Kinase (Chk) (2) Cholinesterase (ChE) (5) COX (10) Cyclin G-associated Kinase (GAK) (3) Cytochrome P450 (5) Dimethylargininase (DDAH) (1) DNA Alkylator/Crosslinker (2) DNA/RNA Synthesis (15) Dopamine Receptor (1) Dopamine β-hydroxylase (2) Drug Derivative (8) Drug Metabolite (2) Dynamin (1) E1/E2/E3 Enzyme (3) EAAT (2) Early 2 Factor (E2F) (1) EGFR (20) Elastase (1) Endogenous Metabolite (17) Environmental Pollutants (6) Epigenetic Reader Domain (4) ERK (18) Estrogen Receptor/ERR (1) Eukaryotic Initiation Factor (eIF) (2) FAK (4) Fat Mass and Obesity-associated Protein (FTO) (1) Fatty Acid Synthase (FASN) (1) Ferroptosis (7) FGFR (1) FLT3 (3) FOXO (2) Fungal (11) FXR (10) G protein-coupled Bile Acid Receptor 1 (8) G-quadruplex (3) GABA Receptor (2) Glucocorticoid Receptor (4) GLUT (1) Glutathione Peroxidase (7) Glutathione S-transferase (1) Glycosidase (2) GSK-3 (1) HBV (1) HCV (5) HDAC (9) Heme Oxygenase (HO) (3) Hexokinase (1) HIF/HIF Prolyl-Hydroxylase (2) Histone Methyltransferase (5) HIV (2) HSP (6) HSV (4) IAP (4) iGluR (3) IKK (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Influenza Virus (4) Insecticide (3) Insulin Receptor (1) Interleukin Related (14) Isotope-Labeled Compounds (8) JAK (3) JNK (20) Keap1-Nrf2 (6) Lactate Dehydrogenase (3) Ligands for E3 Ligase (1) Lipoxygenase (1) LPL Receptor (8) MAP3K (1) MDM-2/p53 (49) MEK (3) MetAP (1) Methylenetetrahydrofolate Dehydrogenase (MTHFD) (1) METTL3 (2) mGluR (1) MicroRNA (1) Microtubule/Tubulin (16) Mitochondrial Metabolism (8) Mitophagy (2) MMP (16) Molecular Glues (2) Monoamine Oxidase (1) mRNA (3) mTOR (16) MyD88 (2) Na+/K+ ATPase (1) Necroptosis (3) NF-κB (37) NO Synthase (3) Notch (3) Nuclear Factor of activated T Cells (NFAT) (1) Nuclear Hormone Receptor 4A/NR4A (2) Orthopoxvirus (1) P-glycoprotein (15) p38 MAPK (35) PAK (3) Parasite (10) PARP (33) PD-1/PD-L1 (3) PERK (3) Phosphodiesterase (PDE) (2) Phospholipase (1) PI3K (34) Pim (1) PKA (1) PKC (1) Polo-like Kinase (PLK) (2) Potassium Channel (1) PPAR (8) Prostaglandin Receptor (1) PROTACs (13) Protease Activated Receptor (PAR) (1) Pyroptosis (1) Raf (6) RAR/RXR (2) Ras (5) Reactive Oxygen Species (ROS) (62) Reference Standards (40) Ribosomal S6 Kinase (RSK) (1) ROS Kinase (2) Serpin (1) SHMT (1) SHP1 (1) Sirtuin (1) Small Interfering RNA (siRNA) (24) Smo (1) SOD (11) Src (2) STAT (13) STING (1) Succinate Dehydrogenase (1) Survivin (7) Syk (1) Tau Protein (1) Telomerase (2) TGF-beta/Smad (11) TGF-β Receptor (1) Thymidylate Synthase (2) TNF Receptor (8) Toll-like Receptor (TLR) (7) Topoisomerase (13) Transferrin Receptor (1) TRP Channel (3) Tyrosinase (3) ULK (1) VD/VDR (1) VDAC (1) VEGFR (21) Virus Protease (1) WDR5 (2) Wnt (1) α-synuclein (1) β-catenin (3)
By Research Areas:	Cancer (425) Cardiovascular Disease (43) Endocrinology (8) Infection (51) Inflammation/Immunology (80) Metabolic Disease (34) Neurological Disease (54)
Oligonucleotides:	Aptamers (2) Rat Pre-designed siRNA Sets (7) mRNA (3) Mouse Pre-designed siRNA Sets (7) Human Pre-designed siRNA Sets (10) Polymers (1) Antisense Oligonucleotides (7) Cholesterol (2) Interleukin & Receptors (1) siRNAs (24)

534

Inhibitors & Agonists

Screening Libraries

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

121

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: Bcl-2 Family BCL6

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10087

Navitoclax 145+ Cited Publications ABT-263	Bcl-2 Family	Cancer
Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-x_L, Bcl-2 and Bcl-w, with a K_i of less than 1 nM .

HY-13407

Gossypol 5+ Cited Publications BL 193	Bcl-2 Family	Cancer
Gossypol binds to *Bcl-xL* protein and *Bcl-2* protein with K_is of 0.5-0.6 μM and 0.2-0.3 mM, respectively.

HY-17510

Gossypol (acetic acid) 5+ Cited Publications (±)-Gossypol-acetic acid; BL-193 (acetic acid)	Bcl-2 Family	Cancer
Gossypol acetic acid ((±)-Gossypol-acetic acid) binds to *Bcl-xL* protein and *Bcl-2* protein with K_is of 0.5-0.6 μM and 0.2-0.3 mM, respectively.

HY-50868

Bafetinib 10+ Cited Publications INNO-406; NS-187	Bcr-Abl Src Apoptosis	Cancer
Bafetinib is an orally active Lyn/Bcr-Abl tyrosine kinase inhibitor. Bafetinib enhances the activity of several pro-apoptotic Bcl-2 homology (BH) 3-pure proteins (Bim, Bad, Bmf, and Bik) through intrinsic apoptotic pathways regulated by the Bcl-2 family, and induces apoptosis of Ph ⁺ leukemia cells. Bafetinib has antitumor activity ^[2] .

HY-N2897

Dihydrokaempferol 5+ Cited Publications	Apoptosis Bcl-2 Family	Inflammation/Immunology
Dihydrokaempferol is isolated from Bauhinia championii (Benth). Dihydrokaempferol induces apoptosis and inhibits Bcl-2 and Bcl-xL expression. Dihydrokaempferol is a good candidate for new antiarthritic agents .

HY-129179

Lisaftoclax 1 Publications Verification APG-2575; Bcl-2/Bcl-xl inhibitor 1	Bcl-2 Family	Cancer
Lisaftoclax (compound 6) is a dual *Bcl-2* and *Bcl-xl* inhibitor with anti-tumor activity, extracted from patent WO2018027097A1. Lisaftoclax exhibits IC₅₀ values of 2 nM and 5.9 nM for Bcl-2 and Bcl-xl, respectively .

HY-15191

Sabutoclax 1 Publications Verification BI-97C1	Bcl-2 Family	Cancer
Sabutoclax is a potent and effective Bcl-2 Family (Bcl-2, Bcl-XL, Mcl-1, Bfl-1) inhibitor with IC₅₀s of 0.32 μM, 0.31 μM, 0.20 μM, and 0.62 μM, respectively. Sabutoclax increases Bax, Bim, PUMA and survivin expression ^[2].

HY-125876

*PROTAC Bcl2* degrader-1** 1 Publications Verification	PROTACs Bcl-2 Family	Cancer
PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC based on Cereblon ligand, which potently and selectively induces the degradation of *Bcl-2* (IC₅₀, 4.94 μM; DC₅₀, 3.0 μM) and Mcl-1 (IC₅₀, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1 (Blue: CRBN ligand, Black: linker；Pink: Mcl-1/Bcl-2 inhibitor, Nap-1).

HY-125877

PROTAC Mcl1 degrader-1 1 Publications Verification	PROTACs Bcl-2 Family	Cancer
PROTAC Mcl1 degrader-1 (compound C3), a proteolysis targeting chimera (PROTAC) based on Cereblon ligand, is a potently and selectively Mcl-1 (Bcl-2 family member) inhibitor with an IC₅₀ of 0.78 μM. PROTAC Mcl1 degrader-1 inhibits *Bcl-2* with an IC₅₀ of 0.54 μM .

HY-12020

TW-37 4 Publications Verification	Bcl-2 Family	Cancer
TW-37 is a potent *Bcl-2* inhibitor with K_i values of 260, 290 and 1110 nM for Mcl-1, *Bcl-2* and *Bcl-xL*, respectively.

HY-12011

HA14-1 2 Publications Verification	Bcl-2 Family	Cancer
HA14-1 is a *Bcl-2/Bcl-X_L* antagonist. HA14-1 binds the designated pocket on Bcl-2 with the IC₅₀ of ≈9 μM in competing with the Bcl-2 binding of Flu-BakBH3, and inhibits its function.

HY-132307

Mcl-1 inhibitor 6	Bcl-2 Family Apoptosis	Cancer
Mcl-1 inhibitor 6 is an orally active, selective myeloid cell leukemia 1 (Mcl-1) protein inhibitor with a K_d of 0.23 nM and a K_i of 0.02 μM. Mcl-1 inhibitor 6 possesses superior selectivity over other Bcl-2 family members (Bcl-2, Bcl2A1, Bcl-xL, and Bcl-w, K_d>10 μM). Mcl-1 inhibitor 6 is a potent antitumor agent .

HY-129700

*MCL-1/BCL-2-IN-2*	Bcl-2 Family	Cancer
MCL-1/BCL-2-IN-2 (Compound 6) is a potent and selective Mcl-1 and *Bcl-2* dual inhibitor .

HY-142209

ABBV-167	Bcl-2 Family	Cancer
ABBV-167 is a phosphate prodrug of the BCL-2 inhibitor venetoclax .

HY-161410

WH244	PROTACs Apoptosis Bcl-2 Family	Cancer
WH244 is a second generation *BCL-2* and *BCL-xL* dual depressant (PROTAC). The primary activity of WH244 is the specific degradation of *BCL-2* and *BCL-xL* proteins (BCL-xL: DC₅₀=0.6 nM, BCL-2: DC₅₀=7.4 nM). WH244 promotes their ubiquitination and subsequent proteasome degradation by targeting these proteins, thereby restoring the cell's apoptosis pathway. WH244 has good antitumor activity. (Pink: BCL-2/BCL-xL ligand (HY-161415); Blue: E3 ligase ligand (HY-112078); Black: linker) .

HY-P1527

Bim BH3 1 Publications Verification	Bcl-2 Family	Others
Bim BH3 is a biological active peptide. (This Bim peptide belongs to the pro-apoptotic Bcl-2 family of proteins.)

HY-138697

S65487 VOB560	Bcl-2 Family Apoptosis	Cancer
S65487 (VOB560), a potent and selective *BCL-2* inhibitor, is a proagent of S55746. S65487 is also active on BCL-2 mutations, such as G101V and D103Y. S65487 has poor affinity with MCL-1, BFL-1 and BCL-XL. S65487 induces apoptosis and has anticaner activities ^[2].

HY-16014

A-385358	Bcl-2 Family	Cancer
A-385358 is a selective inhibitor of *Bcl-X_L* with K_is of 0.80 and 67 nM for *Bcl-X_L* and *Bcl-2*, respectively.

HY-129702

*MCL-1/BCL-2-IN-4*	Bcl-2 Family	Cancer
MCL-1/BCL-2-IN-4 (Compound 7) is a potent and selective Mcl-1 and *Bcl-2* dual inhibitor .

HY-129681

*MCL-1/BCL-2-IN-1*	Bcl-2 Family	Cancer
MCL-1/BCL-2-IN-2 (Compound Nap-1) is a potent and selective Mcl-1 and *Bcl-2* dual inhibitor with IC₅₀s of 4.45 and 3.18 μM, respectively .

HY-10087R

Navitoclax (Standard) ABT-263 (Standard)	Reference Standards Bcl-2 Family	Cancer
Navitoclax (Standard) is the analytical standard of Navitoclax. This product is intended for research and analytical applications. Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM .

HY-109617

4-(4-Fluorophenyl)benzoic acid	Bcl-2 Family	Cancer
4-(4-Fluorophenyl)benzoic acid (Compoud 6) can bind to Bcl-2 with a K_D value of 400 μM. 4-(4-Fluorophenyl)benzoic acid can be used to develope Bcl-2 selective anti-cancer agent .

HY-101083

BDA-366	Bcl-2 Family	Cancer
BDA-366 is a potent *Bcl2* antagonist (K_i = 3.3 nM), binding Bcl2-BH4 domain with high affinity and selectivity. BDA-366 induces conformational change in Bcl2 that abrogates its antiapoptotic function, converting it from a survival molecule to a cell death inducer. BDA-366 suppresses growth of lung cancer cells .

HY-N1157

Thevetiaflavone Apigenin-5-methyl ether	Bcl-2 Family Caspase	Neurological Disease
Thevetiaflavone could upregulate the expression of *Bcl-2* and downregulate that of Bax and caspase-3.

HY-13408

(+)-Apogossypol Apogossypol; NSC736630	Bcl-2 Family	Cancer
(+)-Apogossypol is a *pan-BCL-2* antagonist. (+)-Apogossypol binds to Mcl-1, *Bcl-2* and *Bcl-xL* with EC₅₀s of 2.6, 2.8 and 3.69 µM, respectively.

HY-15464D

(S)-Gossypol (acetic acid) 4 Publications Verification (S)-(+)-Gossypol acetic acid	Bcl-2 Family	Cancer
(S)-Gossypol is the isomer of a natural product Gossypol. (S)-Gossypol binds to the BH3-binding groove of *Bcl-xL* and *Bcl-2* proteins with high affinity.

HY-139309

*PROTAC Bcl-xL degrader-2*	Bcl-2 Family PROTACs	Cancer
PROTAC Bcl-xL degrader-2 is a potent *Bcl-xL* (Bcl-2 family member) degrader based on von Hippel-Lindau ligand, with an IC₅₀ of 0.6 nM.

HY-118874A

Oblimersen sodium	Apoptosis Bcl-2 Family	Cancer
Oblimersen sodium is a *BCL-2* inhibitor targeting BCL-2 RNA. Oblimersen sodium specifically binds to the first six codons of the bcl-2 mRNA sequence, resulting in degradation of bcl-2 mRNA and induces apoptosis by down-regulating expression of Bcl-2. Oblimersen sodium can be used for cancer research ^[2] .

HY-19551

Apogossypolone ApoG2	Bcl-2 Family Apoptosis Autophagy Fungal ROS Kinase	Infection Cancer
Apogossypolone (ApoG2) is an orally active Bcl-2 family proteins inhibitor with K_i values of 35, 25 and 660 nM for Bcl-2, Mcl-1 and Bcl-X_L, respectively. Apogossypolone shows antitumor activities, induces cell apoptosis and autophagy ^[2]. Apogossypolone also has antifungal activity .

HY-16967

MM41	G-quadruplex Bcl-2 Family Ras Caspase	Cancer
MM41 is a quadruplex-interacting compound. MM41 binds tightly to quadruplexes encoded in the promoter sequences of the BCL-2 and k-RAS genes. MM41 reduces *BCL-2* and k-RAS protein levels, increases caspase 3. MM41 has antitumor effects against pancreatic cancer .

HY-P2343

BH3 hydrochloride	Apoptosis	Cancer
BH3 hydrochloride, a BBB penetrated peptide, provoke apoptosis either by direct activation of pro-apoptotic Bax/Bak or by neutralizing anti-apoptotic Bcl-2 proteins (Bcl-2, Bcl-XL, Bcl-w, Mcl-1 and A-1) via their BH3 domian ^[2].

HY-138697A

S65487 sulfate VOB560 sulfate	Bcl-2 Family Apoptosis	Cancer
S65487 (VOB560) sulfate, a potent and selective *Bcl-2* inhibitor, is a proagent of S55746. S65487 sulfate is also active on BCL-2 mutations, such as G101V and D103Y. S65487 sulfate has poor affinity with MCL-1, BFL-1 and BCL-XL. S65487 sulfate induces apoptosis and has anticaner activities ^[2].

HY-135273

A-1211212 BCL2-IN-1	Bcl-2 Family	Cancer
A-1211212 (BCL2-IN-1), a chemical probe, is a potent *Bcl-2* inhibitor. BCL2-IN-1 binds Bcl-2 with a K_i of <0.01 nM .

HY-156620

Lacutoclax LP-108	Bcl-2 Family	Cancer
Lacutoclax is a Bcl-2 inhibitor with antineoplastic activity .

HY-129701

*MCL-1/BCL-2-IN-3*	Bcl-2 Family	Cancer
MCL-1/BCL-2-IN-3 (Compound 2) is a potent and selective Mcl-1 and *Bcl-2* dual inhibitor with IC₅₀s of 5.95 and 4.78 μM, respectively .

HY-118874

Oblimersen	Bcl-2 Family Apoptosis	Cancer
Oblimersen is a *BCL-2* inhibitor targeting BCL-2 RNA. Oblimersen specifically binds to the first six codons of the bcl-2 mRNA sequence, resulting in degradation of bcl-2 mRNA and induces apoptosis by down-regulating expression of Bcl-2. Oblimersen can be used for cancer research ^[2] .

HY-10087S

Navitoclax-d8 1 Publications Verification	Bcl-2 Family	Cancer
Navitoclax-d₈ is the deuterium labeled Navitoclax. Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM .

HY-N1218

Stellasterol	Glycosidase Bcl-2 Family	Others
Stellasterol is a natural product. Stellasterol has high affinity towards *Bcl-2* protein (K_i: 118.05 nM). Stellasterol is a weak α-glucosidase inhibitor ^[2].

HY-RS01417

BCL2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Bcl-2 Family	Others
BCL2 Rat Pre-designed siRNA Set A contains three designed siRNAs for BCL2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

BCL2 Rat Pre-designed siRNA Set A BCL2 Rat Pre-designed siRNA Set A

HY-RS01415

BCL2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Bcl-2 Family	Others
BCL2 Human Pre-designed siRNA Set A contains three designed siRNAs for BCL2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

BCL2 Human Pre-designed siRNA Set A BCL2 Human Pre-designed siRNA Set A

HY-131247

Bcl-2-IN-2	Bcl-2 Family	Inflammation/Immunology Cancer
Bcl-2-IN-2 is a potent and selective *Bcl-2* inhibitor with an IC₅₀ of 0.034 nM and also inhibits Bcl-xL with an IC₅₀ of 43 nM, showing >1000-fold selectivity for Bcl-2 over Bcl-xL .

HY-149009

Bcl-2-IN-9	Bcl-2 Family Apoptosis	Cancer
Bcl-2-IN-9 is a novel proapoptotic *Bcl-2* inhibitor with IC₅₀ value of 2.9 μM and low cytotoxic. Bcl-2-IN-9 mediates apoptosis by down-regulating expression of Bcl-2 in cancer cells and has a high selectivity against leukemia cells .

HY-RS01416

Bcl2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Bcl-2 Family	Others
Bcl2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bcl2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Bcl2 Mouse Pre-designed siRNA Set A Bcl2 Mouse Pre-designed siRNA Set A

HY-160108

Bcl-2-IN-17	Bcl-2 Family	Others
Bcl-2-IN-17 is a *Bcl2* inhibitor and can be used for the research of diseases associated with Bcl anti-apoptotic protein .

HY-153953

Bcl-2-IN-11	Bcl-2 Family	Cancer
Bcl-2-IN-11 (compound 6) is a potent and selective *Bcl-2* activity inhibitor, with an IC₅₀ of 0.9 nM. Bcl-2-IN-11 shows weak inhibition of Bcl-xl (IC₅₀ > 1000 nM). Bcl-2-IN-11 can be used for the research of a variety of cancers caused by abnormal overexpression of Bcl-2 family proteins: especially malignant hematologic diseases of acute lymphoid leukemia, etc. Bcl-2-IN-11 can also avoid toxic side effects caused by Bcl-xl inhibition, such as thrombocytopenia .

HY-174403

*c-MYC/BCL2* ligand 1 iodide**	Bcl-2 Family c-Myc Apoptosis Caspase	Cancer
c-MYC/BCL2 ligand 1 iodide is a dual-targeting *c-MYC/Bcl-2* G4 ligand with K_d values of 0.90 μM (c-MYC G4) and 0.56 μM (Bcl-2** G4). c-MYC/BCL2 ligand 1 iodide inhibits c-MYC and *Bcl-2* gene transcription by binding to G4-forming sequences and downregulates their protein expression. c-MYC/BCL2 ligand 1 iodide inhibits suppresses migration, induces caspase-dependent apoptosis, and triggers cell cycle G1 arrest in MCF-7 cells. c-MYC/BCL2 ligand 1 iodide significantly suppresses tumor growth in a 4T1 syngeneic model with no observable toxicity. c-MYC/BCL2 ligand 1 iodide can be used for the research of breast cancer.

HY-143872

Bcl-2-IN-4	Bcl-2 Family	Cancer
Bcl-2-IN-4 is a potent, orally active and selective Bcl-2 inhibitor with an IC₅₀ of 1.5 nM. Bcl-2-IN-4 displays >200-fold selectivity over Bcl-xL (IC₅₀ of 411 nM). Bcl-2-IN-4 inhibits RS4; 11 cell proliferation with an IC₅₀ of 2.7 nM (WO2021180040A1; compound 2) .

HY-161415

BCL-xL/BCL-2 ligand 1	Ligands for E3 Ligase	Cancer
BCL-xL/BCL-2 ligand 1 (compound 72-1) is a *BCL-xL* and *BCL-2* protein ligand. BCL-xL/BCL-2 ligand 1 can be connected to the E3 ligase by a linker to form PROTACs (HY-161410) ^[2].

HY-149681

*Beclin1-Bcl-2* interaction inhibitor 1**	Bcl-2 Family Beclin1	Neurological Disease Cancer
Beclin1-Bcl-2 interaction inhibitor 1 is a Beclin1 and *Bcl-2* interaction inhibitor with an IC₅₀ value of 4.4 nM. Beclin1-Bcl-2 interaction inhibitor 1 disrupts the binding of the Bcl-2-Beclin 1 BH3 domain. Beclin1-Bcl-2 interaction inhibitor 1 can be used in the research of cancer and neurodegenerative diseases .

HY-10087A1

Navitoclax dihydrochloride ABT-263 dihydrochloride	Bcl-2 Family	Cancer
Navitoclax (ABT-263) dihydrochloride is an orally active *Bcl-2* inhibitor that binds to various *Bcl-2* family proteins, including *Bcl-xL, Bcl-2, and Bcl-w, with a K_i* value of less than 1 nM. Navitoclax dihydrochloride can be used in cancer research .

Cat. No.	Product Name

HY-L003

Apoptosis Compound Library

3,407 compounds

Apoptosis is an ordered and orchestrated cellular process that occurs in physiological and pathological conditions, which is also called programmed cell death (PCD). Apoptosis plays a crucial role in developing and maintaining the health of the body by eliminating old cells, unhealthy cells and unnecessary cells. Too little or too much apoptosis contribute to many diseases. When apoptosis does not work correctly, cells that should be eliminated may persist and become immortal, for example, in cancer and leukemia. When apoptosis works overly well, it kills too many cells and inflicts grave tissue damage. This is the case in strokes and neurodegenerative disorders such as Alzheimer's, Huntington's, and Parkinson's disease.

MCE designs a unique collection of 3,407 apoptosis-related compounds mainly focusing on the key targets in the apoptosis signaling pathway and can be used in the research of apoptosis signal pathway and related diseases.

Cat. No.	Product Name	Type

HY-W250111

Carboxymethyl chitosan

Biochemical Assay Reagents

Carboxymethyl chitosan is a derivative of chitosan. Carboxymethyl chitosan inhibits Apoptosis and ROS. Carboxymethyl chitosan increases the expression of Bcl-2 and reduces the expression of Bax, cytochrome c and caspase-3. Carboxymethyl chitosan inhibits the migration of various cells. Carboxymethyl chitosan exerts antitumor effects on Lewis tumors and hepatocarcinoma ^[2] .

HY-126437

Poly-L-lysine hydrobromide (MW 30000-70000)

1 Publications Verification

Biochemical Assay Reagents

Poly-L-lysine hydrobromide (MW 30000-70000) is a water-soluble synthetic polypeptide. Poly-L-lysine hydrobromide (MW 30000-70000) downregulates Bcl-2 and upregulates Bax and p53 proteins. Poly-L-lysine hydrobromide (MW 30000-70000) promotes Apoptosis and reduces VEGF expression. Poly-L-lysine hydrobromide (MW 30000-70000) shows anticancer activity against a variety of tumors. Poly-L-lysine hydrobromide (MW 30000-70000) can also be used as a coating material ^[2] .

HY-W250122

Glutamic acid sodium salt

1 Publications Verification

Monosodium glutamate

Biochemical Assay Reagents

Glutamic acid sodium salt (Monosodium glutamate) is an orally active food flavor enhancer. Glutamic acid sodium salt causes ROS generation, mitochondrial dysfunction, and Apoptosis. Glutamic acid sodium salt upregulates CHOP, Grp78, and Bcl-2. Glutamic acid sodium salt impairs cognition, induces depressive-like behavior, induces hyperalgesia, and induces obesity and insulin resistance. Glutamic acid sodium salt can be used to study neurotoxicity (e.g., brain damage, cognitive impairment), metabolic disorders (e.g., obesity, insulin resistance), hepatotoxicity, and renal toxicity, as well as pain-related disorders ^[2] .

HY-W013105

Sodium glycocholate hydrate, 98%

N-Cholylglycine sodium salt, 98%

Biochemical Assay Reagents

Sodium glycocholate hydrate, 98% is a bile acid derivative. Sodium glycocholate hydrate, 98% downregulates MDR1, Bcl-2, MRP1, MRP2 and FXR, upregulates Bax, p53, caspase-9, caspase-3, TGR5 and S1PR2. Sodium glycocholate hydrate, 98% inhibits multidrug resistance and efflux pumps, induces mitochondrial apoptosis, and enhances chemosensitivity. Sodium glycocholate hydrate, 98% modulates related bile acid receptor signaling. Sodium glycocholate hydrate, 98% suppresses growth and conjugation of Enterobacteriaceae and increases their antibiotic susceptibility. Sodium glycocholate hydrate, 98% can be used for the research of colon adenocarcinoma and cholangiocarcinoma (CCA) ^[2] .

HY-159059

Ganoderma Lucidum/Reishi Extract

Biochemical Assay Reagents

Ganoderma Lucidum/Reishi Extract is a Ganoderma lucidum extract. Ganoderma Lucidum/Reishi Extract reduces the expression of c-Myc, BCL-2, BCL-XL, TERT, PDGFB, eIF4G, Survivin, β-catenin, and eIF4E. Ganoderma Lucidum/Reishi Extract downregulates the gene expression of MMP-9. Ganoderma Lucidum/Reishi Extract upregulates the expression of IL8. Ganoderma Lucidum/Reishi Extract is applicable to the research of inflammatory breast cancer. Ganoderma Lucidum is used in the research of various diseases, such as allergy, arthritis, hypertension, neurasthenia, inflammation, and cancer ^[2].

HY-NP192

Sericin

Biochemical Assay Reagents

Sericin is an orally active globular protein produced by silkworm cocoons. Sericin inhibits the expression of COX2, iNOS, TLR4, MAPK and NF-κB; reduces the levels of IL-18, IL-1 and CCL2; antagonizes the activity of AChE; and downregulates the expression of Bcl-2. Sericin enhances the PI3K/AKT-mediated insulin signaling pathway. Sericin inhibits the activity of tyrosinase (Tyrosinase), scavenges ROS, chelates metal ions, and increases the levels of antioxidant enzymes. Sericin induces apoptosis and arrests the cell cycle. Sericin exhibits antibacterial, moisturizing, cardioprotective and anticoagulant properties. Sericin can be used in research related to type 2 diabetes, hyperlipidemia, obesity, Alzheimer's disease, colon cancer, peripheral nerve injury and ischemic myocardial infarction ^[2].

Cat. No.	Product Name	Target	Research Area

HY-P1527

Bim BH3 1 Publications Verification	Bcl-2 Family	Others
Bim BH3 is a biological active peptide. (This Bim peptide belongs to the pro-apoptotic Bcl-2 family of proteins.)

HY-P1889

Bim BH3, Peptide IV	Bcl-2 Family	Inflammation/Immunology
Bim BH3, Peptide IV is a 26-residue peptide from BH3-only protein Bim, which belongs to the pro-apoptotic group of the Bcl-2 family of proteins ^[2].

HY-P1380A

Difopein TFA	Apoptosis Bcl-2 Family Caspase	Cancer
Difopein TFA is a 14-3-3 protein inhibitor. Difopein TFA acts as an apoptosis inducer, regulates apoptosis-related proteins, downregulates *Bcl-2, upregulates Bax, activates caspase-9* and caspase-3, and induces nuclear fragmentation, membrane-enclosed apoptotic bodies and DNA ladder formation. Difopein TFA serves as a tumor growth inhibitor, which inhibits the proliferation of glioma cells and induces their apoptosis in in vivo nude mouse models. Difopein TFA is applicable to glioma-related research .

HY-P2343

BH3 hydrochloride	Apoptosis	Cancer
BH3 hydrochloride, a BBB penetrated peptide, provoke apoptosis either by direct activation of pro-apoptotic Bax/Bak or by neutralizing anti-apoptotic Bcl-2 proteins (Bcl-2, Bcl-XL, Bcl-w, Mcl-1 and A-1) via their BH3 domian ^[2].

HY-P10336

Serpinin	Serpin	Neurological Disease Endocrinology
Serpinin is an agonist of the protease inhibitor Nexin-1 (PN-1). Serpinin upregulates the expression of PN-1 through the cAMP-PKA-Sp1 signaling pathway, promoting granule biogenesis in endocrine cells. Serpinin is used in research related to the regulation of secretory function . Serpinin is a selective agonist for β-adrenergic receptors. Serpinin interacts with β1-adrenergic receptors to activate the AC-cAMP-PKA pathway, which regulates myocardial systolic and diastolic function. pGlu-serpinin upregulates Bcl2 mRNA transcription and exerts neuroprotective effects ^[2].

HY-P5325A

Bid BH3 (80-99) acetate	Bcl-2 Family	Others
Bid BH3 (80-99) acetate is a biological active peptide. (BID is a pro-apoptotic member of the 'BH3-only' (BOPS) subset of the BCL-2 family of proteins that constitute a critical control point in apoptosis. Bid is the first of the BOPs reported to bind and activate Bcl-2, Bax, and Bak. Bid serves as a death-inducing ligand that moves from the cytosol to the mitochondrial membrane to inactivate Bcl-2 or to activate Bax.Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)

HY-P5325

Bid BH3 (80-99)	Bcl-2 Family	Others
Bid BH3 (80-99) is a biological active peptide. (BID is a pro-apoptotic member of the 'BH3-only' (BOPS) subset of the BCL-2 family of proteins that constitute a critical control point in apoptosis. Bid is the first of the BOPs reported to bind and activate Bcl-2, Bax, and Bak. Bid serves as a death-inducing ligand that moves from the cytosol to the mitochondrial membrane to inactivate Bcl-2 or to activate Bax.Pyroglutamyl (pGlu) peptides may spontaneously form when either Glutamine (Q) or Glutamic acid (E) is located at the sequence N-terminus. The conversion of Q or E to pGlu is a natural occurrence and in general it is believed that the hydrophobic γ-lactam ring of pGlu may play a role in peptide stability against gastrointestinal proteases. Pyroglutamyl peptides are therefore considered a normal subset of such peptides and are included as part of the peptide purity during HPLC analysis.)

HY-P11374

Bid BH3-Gly-r8	Bcl-2 Family Apoptosis	Cancer
Bid BH3-Gly-r8 is Bid BH3 linked to eight arginine residues. Bid BH3-Gly-r8 shows no difference in apoptotic effects compared to its unmodified peptide homologue. Bid BH3 has high affinity for Bax and *Bcl-2*. Bid BH3-Gly-r8 can be used in the research of tumors .

HY-P10833

C-VGB3	VEGFR PI3K Akt mTOR ERK Apoptosis	Cardiovascular Disease Cancer
C-VGB3 is a selective vascular endothelial growth factor receptor 2 (VEGFR2) antagonist, which inhibits VEGFR2-mediated PI3K/AKT/mTOR and PLCγ/ERK1/2 signaling pathways. C-VGB3 binds to the extracellular domain of VEGFR2, blocking ligand-receptor interaction and inducing apoptosis in endothelial and tumor cells through both intrinsic (involving Bcl2 family and caspases) and extrinsic (death receptor-mediated) pathways. C-VGB3 is promising for research of angiogenesis-related cancers, such as breast cancer ^[2].

HY-P10057

cpm-1285	Apoptosis	Cancer
cpm-1285 induces apoptosis by functionally blocking intracellular Bcl-2 and related death antagonists. cpm-1285 shows strong binding potency to Bcl-2 with an IC₅₀ value of 130 nM. cpm-1285 reduces tumor burden in mice .

HY-P5327

r8 Bid BH3	Bcl-2 Family	Others
r8 Bid BH3 is a biological active peptide. (The Bid BH3 is a pro-apoptotic member of the 'BH3-only' subset of BCL-2 family proteins that constitute a critical control point in apoptosis. r8BIDBH3 is lethal to human leukemia cell lines that expresse Bcl-2. The Bcl-2 antagonists may have the potential to be efficacious in cancer therapy. Poly-D-arginine (d-isomer as denoted by rrrrrrrr) is fused to the Bid BH3 peptide to facilitate cellular uptake of the peptide.)

HY-P10058

cpm-1285m	Biochemical Assay Reagents	Cancer
cpm-1285m is a cell-permeable mutated peptide analogue of cpm-1285 (Bcl-2 inhibitory peptide). cpm-1285m contains a single substitution of alanine for Leu-151, and exhibits a decrease in *Bcl-2* binding affinity with a reduction in IC₅₀ of ∼15-fold. cpm-1285m can be used as a control of cpm-1285 .

HY-P5324

Bad BH3 (mouse)	Bcl-2 Family	Others
Bad BH3 (mouse) is a biological active peptide. (This is a bcl-2 binding peptide. This peptide is derived from the BH3 domain (a death domain) of Bad, amino acid residues 140 to 165.)

HY-P1889A

Bim BH3, Peptide IV TFA	Bcl-2 Family	Inflammation/Immunology
Bim BH3, Peptide IV TFA is a 26-residue peptide from BH3-only protein Bim, which belongs to the pro-apoptotic group of the Bcl-2 family of proteins ^[2].

HY-P1733

BMf-BH3 BMF-Y	Apoptosis	Cancer
BMf-BH3 (BMF-Y) belongs to the Bcl-2 apoptosis mediator family. BH3-only protein, Bmf is a key molecule for histone deacetylase (HDAC) inhibitors mediated enhancing effect on ionizing radiation-induced cell death ^[2].

HY-P11707

FS1 peptide	Apoptosis Bcl-2 Family	Inflammation/Immunology
FS1 peptide is a synthetic BH3 mimetic peptide that shows potential in enhancing NK cell-mediated cancer immunity. FS1 peptide targets anti-apoptotic *BCL-2* family proteins, triggers the release of cytochrome c, and thereby promotes apoptosis (Apoptosis). FS1 peptide can be used for NK cell-based immunological research .

HY-P1380

Difopein	Apoptosis Bcl-2 Family Caspase	Cancer
Difopein is a 14-3-3 protein inhibitor. Difopein acts as an apoptosis inducer, regulates apoptosis-related proteins, downregulates *Bcl-2, upregulates Bax, activates caspase-9* and caspase-3, and induces nuclear fragmentation, membrane-enclosed apoptotic bodies and DNA ladder formation. Difopein serves as a tumor growth inhibitor, which inhibits the proliferation of glioma cells and induces their apoptosis in in vivo nude mouse models. Difopein is applicable to glioma-related research .

Cat. No.	Product Name	Target	Research Area	Image

HY-P990344

*Anti-Bcl-2* Antibody**	Bcl-2 Family	Inflammation/Immunology
The Anti-Bcl-2 Antibody is a humanized antibody expressed in CHO cells, targeting *Bcl-2. The Anti-Bcl-2* Antibody has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145.74 kDa. The isotype control for Anti-Bcl-2 Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P991883

Metuzumab Licartin; Metuximab; Mehuzumab	Apoptosis CDK Caspase Bcl-2 Family	Cancer
Metuzumab (Licartin) is a human-mouse chimeric IgG1 monoclonal antibody targeting CD147. Metuzumab induces Apoptosis, reduces levels of Cyclin D1, full-length Caspase-3, and *Bcl-2, and increases Bax* expression. Metuzumab enhances the sensitivity of non-small cell lung cancer (NSCLC) cells to Gemcitabine (HY-17026). Metuzumab is applicable for research on hepatocellular carcinoma and non-small cell lung cancer [1] [2]_.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N1423

Glycocholic acid 3 Publications Verification	Structural Classification Human Gut Microbiota Metabolites Classification of Application Fields Endogenous metabolite Disease Research Fields Steroids Source Classification Cancer	P-glycoprotein Bcl-2 Family G protein-coupled Bile Acid Receptor 1 Endogenous Metabolite Bacterial Apoptosis FXR Caspase MDM-2/p53 LPL Receptor
Glycocholic acid is a bile acid derivative. Glycocholic acid downregulates MDR1, *Bcl-2, MRP1, MRP2* and FXR, upregulates Bax, p53, caspase-9, caspase-3, TGR5 and *S1PR2. Glycocholic acid inhibits multidrug resistance and efflux pumps, induces mitochondrial apoptosis*, and enhances chemosensitivity. Glycocholic acid modulates related bile acid receptor signaling. Glycocholic acid suppresses growth and conjugation of Enterobacteriaceae and increases their antibiotic susceptibility. Glycocholic acid can be used for the research of colon adenocarcinoma and cholangiocarcinoma (CCA) ^[2] .

HY-N0292

Oleuropein 5+ Cited Publications	Cardiovascular Disease Classification of Application Fields Anti-aging Plants Burseraceae Iridoids Canarium album (Lour.) Rauesch. Terpenoids Phenols Polyphenols Inflammation/Immunology Disease Research Fields Source Classification Cancer	Cytochrome P450 PPAR Apoptosis
Oleuropein, found in olive leaves and oil, exerts antioxidant, anti-inflammatory and anti-atherogenic effects through direct inhibition of PPARγ transcriptional activity . Oleuropein induces apoptosis in breast cancer cells via the p53-dependent pathway and through the regulation of Bax and Bcl2 genes. Oleuropein also inhibits aromatase ^[2].

HY-N2342

Procyanidin C1 5+ Cited Publications PCC1	Classification of Application Fields Rosaceae Crataegus pinnatifida Bge. Plants Flavonoids Functional Molecules Research of Health Products Phenols Polyphenols Biflavones Disease Research Fields Source Classification Cancer	Apoptosis
Procyanidin C1 (PCC1), a natural polyphenol with oral activity, causes DNA damage, cell cycle arrest and induces apoptosis. Procyanidin C1 decreases the level of Bcl-2, but enhances BAX, caspase 3 and 9 expression in cancer cells. Procyanidin C1 shows senotherapeutic activity and increases lifespan in mice ^[2].

HY-N0168

Hesperetin 20+ Cited Publications	Structural Classification Flavonoids other families Neurological Disease Classification of Application Fields Sunscreen Flavonones Cosmetic Research Plants Disease Research Fields Source Classification Cancer	p38 MAPK Autophagy Apoptosis Reactive Oxygen Species (ROS) NF-κB Bcl-2 Family
Hesperetin is a natural flavanone that can be found in citrus, and acts as a potent and orally active broad-spectrum inhibitor against human UGT activity. Hesperetin induces apoptosis via p38 MAPK activation. Hesperetin displays a range of bioactivities including antioxidant, anti-inflammatory, and anti-cancer. Hesperetin is found to induce cell-cycle arrest at G2/M phase. Hesperetin can reduce *Bcl-2* and enhance BaxM. Hesperetin induces apoptosis through inhibiting NF-κB receptor ^[2] .

HY-13407

Gossypol 5+ Cited Publications BL 193	Malvaceae Classification of Application Fields Phenols Polyphenols Gossypium herbaceum Linn. Plants Disease Research Fields Source Classification Cancer	Bcl-2 Family
Gossypol binds to *Bcl-xL* protein and *Bcl-2* protein with K_is of 0.5-0.6 μM and 0.2-0.3 mM, respectively.

HY-126477

NNK 2 Publications Verification	Structural Classification Alkaloids Classification of Application Fields Pyridine Alkaloids Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite
NNK is a nicotine-nitrosated derivative. NNK simultaneously stimulates *Bcl2* phosphorylation exclusively at Ser ⁷⁰ and c-Myc at Thr ⁵⁸ and Ser ⁶² through activation of both *ERK1/2* and PKCα . NNK induces survival and proliferation of human lung cancer cells. NNK can be used for lung cancer mice model structure ^[2].

HY-107738

Guggulsterone 20+ Cited Publications Z/E-Guggulsterone	Triterpenes Structural Classification Classification of Application Fields Terpenoids Plants Burseraceae Disease Research Fields Commiphora wightii Cancer	Apoptosis JNK Akt Caspase FXR Autophagy
Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (*IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt* ^[2]. Guggulsterone, a farnesoid X receptor (FXR) antagonist, with IC₅₀s of 24.06 μM and 39.05 μM for (-)-(E)-Guggulsterone (HY-N7781) and (Z)-Guggulsterone (HY-110066), respectively .

HY-N0087

Gambogic Acid 5+ Cited Publications Beta-Guttiferrin	Natural Products Classification of Application Fields Guttiferae Plants Garcinia hanburyi Hook. f. Disease Research Fields Cancer	Bcl-2 Family Autophagy
Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits *Bcl-X_L, Bcl-2, Bcl-W, Bcl-B, Bfl-1* and Mcl-1 with IC₅₀s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM.

HY-N0674

Dehydrocorydaline 40+ Cited Publications 13-Methylpalmatine	Infection Alkaloids Corydalis yanhusuo W. T. Wang Classification of Application Fields Plants Isoquinoline Alkaloids Disease Research Fields Papaveraceae Source Classification	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline (13-Methylpalmatine) is an alkaloid that regulates protein expression of Bax, *Bcl-2; activates caspase-7, caspase-8, and inactivates PARP* . Dehydrocorydaline elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities ^[2]. Dehydrocorydaline shows strong anti-malarial effects (IC₅₀=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .

HY-126741

Azadirachtin 2 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Other Diseases Azadirachta indica A. Juss. Plants Meliaceae Disease Research Fields Biological Pesticide Research Source Classification Agricultural Research	Environmental Pollutants Parasite Caspase NF-κB Apoptosis Bcl-2 Family
Azadirachtin is an oral active triterpenoid compound with anticancer, antimalarial, anti-inflammatory, and insecticidal activities. Azadirachtin induces cell apoptosis through the mitochondrial pathway (by inhibiting *Bcl-2/Bax* ratio or activating Apaf-1 and caspase-3) or through death receptors (by inhibiting TNFR activation). Additionally, Azadirachtin exerts its anti-inflammatory effects by inhibiting NF-кB signaling pathway activation, and it exhibits insecticidal activity by inducing apoptosis in insect cells ^[2] .

HY-17510

Gossypol (acetic acid) 5+ Cited Publications (±)-Gossypol-acetic acid; BL-193 (acetic acid)	other families Classification of Application Fields Phenols Polyphenols Plants Disease Research Fields Source Classification Cancer	Bcl-2 Family
Gossypol acetic acid ((±)-Gossypol-acetic acid) binds to *Bcl-xL* protein and *Bcl-2* protein with K_is of 0.5-0.6 μM and 0.2-0.3 mM, respectively.

HY-N0068

Solasodine 5 Publications Verification Purapuridine; Solancarpidine; Solasodin	Infection Cardiovascular Disease Alkaloids Piperidine Alkaloids Neurological Disease Classification of Application Fields Solanum nigrum Linn. Solanaceae Plants Inflammation/Immunology Disease Research Fields Source Classification	MDM-2/p53 Fungal E1/E2/E3 Enzyme Apoptosis
Solasodine (Purapuridine) is a steroidal alkaloid that occurs in plants of the Solanaceae family. Solasodine induces apoptosis by inhibiting the p53-MDM2 complex, p21Waf1/Cip1, and Bcl-2 proteins. Solasodine has neuroprotective, antifungal, hypotensive, anticancer, antiatherosclerotic, antiandrogenic and anti-inflammatory activities ^[2] .

HY-N2897

Dihydrokaempferol 5+ Cited Publications	Flavanonols Flavonoids Classification of Application Fields Leguminosae Phenols Polyphenols Bauhinia championii (Benth.) Benth. Plants Inflammation/Immunology Disease Research Fields Source Classification	Apoptosis Bcl-2 Family
Dihydrokaempferol is isolated from Bauhinia championii (Benth). Dihydrokaempferol induces apoptosis and inhibits Bcl-2 and Bcl-xL expression. Dihydrokaempferol is a good candidate for new antiarthritic agents .

HY-N3584

Paris saponin VII 4 Publications Verification Chonglou Saponin VII	Liliaceae Classification of Application Fields Trillium tschonoskii Maxim. Plants Disease Research Fields Steroids Source Classification Cancer	Akt p38 MAPK P-glycoprotein Bcl-2 Family Caspase PARP Autophagy Apoptosis
Paris saponin VII (Chonglou Saponin VII) is a steroidal saponin isolated from the roots and rhizomes of Trillium tschonoskii. Paris saponin VII-induced apoptosis in K562/ADR cells is associated with Akt/MAPK and the inhibition of P-gp. Paris saponin VII attenuates mitochondrial membrane potential, increases the expression of apoptosis-related proteins, such as Bax and cytochrome c, and decreases the protein expression levels of Bcl-2, caspase-9, caspase-3, PARP-1, and p-Akt. Paris saponin VII induces a robust autophagy in K562/ADR cells and provides a biochemical basis in the treatment of leukemia .

HY-N0361

Dihydrocapsaicin 4 Publications Verification	Alkaloids Structural Classification Monophenols Capsicum annuum L. Classification of Application Fields Other Alkaloids Phenols Metabolic Disease Solanaceae Plants Disease Research Fields Source Classification	Environmental Pollutants Caspase Akt Apoptosis Reactive Oxygen Species (ROS) TRP Channel Bcl-2 Family PI3K
Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased *Bcl-2, Bcl-xL* and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat ^[2] .

HY-N0763

Angelicin 10+ Cited Publications Isopsoralen	Classification of Application Fields Leguminosae Coumarins Phenylpropanoids Psoralea corylifolia L. Plants Disease Research Fields Source Classification Cancer	Apoptosis Virus Protease NF-κB p38 MAPK JNK Caspase
Angelicin is a furanocoumarin compound that functions as an inhibitor of NF-κB and MAPK signaling pathways, exhibiting anti-inflammatory, antiviral, and antitumor activities. It suppresses the lytic replication of γ-herpesviruses, such as MHV-68, early during viral infection, potentially inhibiting RTA gene expression (IC₅₀=28.95 μM). Angelicin also mitigates inflammation by inhibiting the phosphorylation and nuclear translocation of NF-κB, and the phosphorylation of p38 and JNK. Furthermore, it induces apoptosis in neuroblastoma cells by downregulating anti-apoptotic proteins like *Bcl-2, Bcl-xL, and Mcl-1, while activating caspase-9* and caspase-3.

HY-P2970

Stem bromelain	Ananas comosus(L.) Merr. Structural Classification Natural Products Classification of Application Fields Bromeliaceae Plants Inflammation/Immunology Disease Research Fields Cancer	Apoptosis PARP Caspase Bcl-2 Family Bacterial Interleukin Related
Stem bromelain (EC 3.4.22.32) is a cysteine protease and antibacterial agent. Stem bromelain can be isolated from the stem of the pineapple (Ananas comosus). Stem bromelain induces dose-dependent secretion of IL-12p70, and IL-6, induces Apoptosis, causes cleavage of full-length PARP protein, Caspase 3, and Caspase 9, increases Bax, and decreases *Bcl-2. Stem bromelain possesses various fibrinolytic, antiedema, antithrombotic, and anti-inflammatory activities. Stem bromelain also exhibits in vivo* antitumor and antileukemic activities, as well as antimetastatic effects. Stem bromelain has antimycobacterial activity. Stem bromelain provides protection against lead poisoning ^[2] .

HY-N0559

Kirenol 1 Publications Verification	Structural Classification Terpenoids Bituminaria morisiana (Pignatti & Metlesics) Greuter Diterpenoids Plants Compositae Source Classification	Casein Kinase Apoptosis AMPK Akt NF-κB TGF-beta/Smad
Kirenol is a diterpenoid compound, an orally active apoptosis inducer and signaling pathway regulator, with a K_d value of 5.47 μM against the target *CK2. Kirenol promotes the cleavage of Bid into tBid, regulates the protein levels/phosphorylation of Bax, Bcl-2, p53* and p21, and induces caspase-independent apoptosis, S-phase cell cycle arrest, ROS accumulation and cytotoxicity in cancer cells. Kirenol activates the *CK2/AKT* and AMPK-mTOR-ULK1 pathways, inhibits the signaling of NF-κB, TGF-β/Smads and NLRP3 inflammasome, and regulates the GSK3β, BMP and Wnt/β-catenin pathways. Kirenol induces autophagy, mitophagy and osteoblast differentiation, promotes mitochondrial fusion, and exerts antioxidant, anti-inflammatory, antifibrotic, renoprotective, cardioprotective, neuroprotective and analgesic effects. Kirenol is applicable to research related to chronic myeloid leukemia, ischemic stroke, diabetic nephropathy, heart failure, acute lung injury and osteoporosis ^[2] .

HY-N0657

Pinoresinol Diglucoside 1 Publications Verification	Structural Classification Eucommia ulmoides Oliver Classification of Application Fields Lignans Other Diseases Eucommiaceae Phenylpropanoids Plants Disease Research Fields Source Classification	NF-κB Keap1-Nrf2 Heme Oxygenase (HO) TGF-beta/Smad Akt mTOR PI3K
Pinoresinol Diglucoside is an orally active lignan with multifunctional bioactivity. Pinoresinol Diglucoside interacts with targets including ALB, HIF1A, GSK3B, *BCL2, MARK3, IL6, NF-κB p65, Nrf2, HO-1, and TLR4, and modulates pathways including PI3K-Akt, estrogen, MAPK, Rap1, AKT/mTOR/NF-κB, and TGF-β1/Smads*. Pinoresinol Diglucoside regulates osteogenesis, bone resorption, oxidative stress, inflammation, apoptosis, ferroptosis, ferritinophagy, cardiac fibrosis, and vasorelaxation. Pinoresinol Diglucoside can be used for the research of osteoporosis, ischemia/reperfusion-induced brain injury, Alzheimer’s disease, myocardial ischemia-reperfusion injury, chondrodysplasia, diabetic cardiomyopathy, cardiac hypertrophy, hypertension, cisplatin-induced hearing loss, atherosclerotic cardiovascular diseases, and disuse osteoporosis ^[2] .

HY-N1423A

Glycocholic acid sodium 3 Publications Verification	Triterpenes Structural Classification Terpenoids Endogenous metabolite Source Classification	P-glycoprotein Bcl-2 Family G protein-coupled Bile Acid Receptor 1 Bacterial Apoptosis FXR Caspase MDM-2/p53 LPL Receptor Endogenous Metabolite
Glycocholic acid sodium is a bile acid derivative. Glycocholic acid downregulates MDR1, *Bcl-2, MRP1, MRP2* and FXR, upregulates Bax, p53, caspase-9, caspase-3, TGR5 and *S1PR2. Glycocholic acid sodium inhibits multidrug resistance and efflux pumps, induces mitochondrial apoptosis*, and enhances chemosensitivity. Glycocholic acid sodium modulates related bile acid receptor signaling. Glycocholic acid sodium suppresses growth and conjugation of Enterobacteriaceae and increases their antibiotic susceptibility. Glycocholic acid sodium can be used for the research of colon adenocarcinoma and cholangiocarcinoma (CCA) ^[2] .

HY-N12060

Ginkgo biloba extract	Structural Classification Natural Products Ginkgoaceae Plants Ginkgo biloba Source Classification	Bcl-2 Family Caspase Apoptosis Autophagy Reactive Oxygen Species (ROS) Akt JNK ERK
Ginkgo biloba extract is a natural product that can be isolated from Ginkgo biloba leaves . Ginkgo biloba extract alleviates oxidative stress-induced neuronal apoptosis (Apoptosis) by stabilizing mitochondrial function, regulating *Bcl-2* family proteins and inhibiting caspase activation. Ginkgo biloba extract alleviates testicular injury by upregulating *SKP2* and inhibiting Beclin1-independent autophagy (Autophagy) . Ginkgo biloba extract alleviates various types of neuronal damage in animal models. Ginkgo biloba extract reduces behavioral sensitization in rats. Ginkgo biloba extract counteracts Aβ-induced neurotoxicity by blocking a series of Aβ-triggered events, including glucose uptake, ROS accumulation, AKT activation, mitochondrial dysfunction, JNK and ERK 1/2 pathways, and apoptosis, and also interferes with the formation of Aβ oligomers. Ginkgo biloba extract is applicable to research related to cerebral hypoperfusion, testicular injury, Alzheimer's disease, Parkinson's disease, multi-infarct dementia, stroke, traumatic brain injury and amyotrophic lateral sclerosis ^[2].

HY-N2067

Vanillyl alcohol 1 Publications Verification p-(Hydroxymethyl)guaiacol	Structural Classification Monophenols Gastrodia elata Bl. Classification of Application Fields Orchidaceae Other Diseases Phenols Plants Disease Research Fields Source Classification	Reactive Oxygen Species (ROS) Bcl-2 Family
Vanillyl alcohol (p-(Hydroxymethyl)guaiacol) is an orally active phenolic alcohol. Vanillyl alcohol reduces ROS generation. suppresses Bax, increases *Bcl-2*. Vanillyl alcohol has anti-angiogenic, anti-inflammatory, anti-nociceptive and neuroprotective effects. Vanillyl alcohol is used as a flavoring agent in foods and beverages ^[2] .

HY-N7675

Flavanomarein	Cardiovascular Disease Structural Classification Classification of Application Fields Cercis chinensis Bunge Metabolic Disease Plants Compositae Flavonoids other families Flavonones Phenols Polyphenols Disease Research Fields Source Classification	NF-κB TGF-beta/Smad Syk
Flavanomarein is a substance with cytoprotective, anti-inflammatory and antioxidant activities, with a K_a of 3.064e-5 M against human Syk. Flavanomarein enhances the phosphorylation level of AKT, regulates the expression of PKC-δ, P85α, PKC-β1, Sirt1, Bcl-2 and ICAD, and inhibits the nuclear translocation of NF-κB p65. Flavanomarein regulates EMT marker proteins, promotes the proliferation of HK-2 cells, and protects neuronal cells from 6-OHDA-induced neurotoxic damage. Flavanomarein can be used in studies related to Parkinson's disease and diabetic nephropathy. ^[2]

HY-N0757

8-O-Acetylharpagide 1 Publications Verification	Infection Structural Classification other families Iridoids Classification of Application Fields Terpenoids Plants Inflammation/Immunology Disease Research Fields Source Classification	Akt Bcl-2 Family Apoptosis Adrenergic Receptor
8-O-Acetylharpagide is an orally active iridoid glycoside compound. 8-O-Acetylharpagide exhibits anti-aging activity at low doses and anticancer activity at high doses. 8-O-Acetylharpagide induces late-stage apoptosis and necrosis-like death in cancer cells, and downregulates anti-apoptotic proteins such as Akt, p-Akt and *Bcl-2. 8-O-Acetylharpagide is mainly metabolized in rats via demethylation, hydrolysis and glucuronidation, and its active metabolites downregulate the AKT/NF-κB/MMP9 signaling axis. 8-O-Acetylharpagide exerts vasoconstrictive effects by activating vascular α-adrenoceptor* ^[2] .

HY-N1255

Scoulerine (-)-Scoulerine; Discretamine	Alkaloids Structural Classification other families Classification of Application Fields Phenols Polyphenols Plants Isoquinoline Alkaloids Disease Research Fields Source Classification Cancer	Bcl-2 Family Apoptosis mTOR GABA Receptor PI3K Adrenergic Receptor Beta-secretase Akt
Scoulerine ((-)-Scoulerine; Discretamine) hydrochloride is a multi-target inhibitor with anti-tumor and antioxidant activities. Scoulerine mainly targets the PI3K/Akt/mTOR signaling axis and α1D-adrenergic receptor, disrupts microtubule structure, and induces cell cycle arrest and apoptosis. Scoulerine effectively inhibits mitochondrial dehydrogenase activity, targets GABA receptors and BACE1, and suppresses the proliferation, migration, invasion, epithelial-mesenchymal transition and stem cell properties of cancer cells. Scoulerine also exhibits multiple pharmacological activities including anti-Plasmodium falciparum, antibacterial, antiemetic and antitussive effects, and regulates endoplasmic reticulum stress and mitochondrial function (modulates Bax, Bcl-2 and cytochrome c). Scoulerine is applicable to research related to leukemia, ovarian cancer, and colorectal cancer ^[2] .

HY-N2416

Taccalonolide A	Classification of Application Fields Plants Disease Research Fields Tacca chantrieri Andre Taccaceae Steroids Cancer Source Classification	Microtubule/Tubulin Apoptosis
Taccalonolide A is a microtubule stabilizer, which is a steroid isolated from Tacca chantrieri, with cytotoxic and antimalarial activities ^[2]. Taccalonolide A causes G₂-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis . Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC₅₀ of 622 nM for SK-OV-3 cells .

HY-N3031

Grosvenorine	Infection Flavonols Structural Classification Flavonoids Classification of Application Fields Cucurbitaceae Phenols Polyphenols Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang Plants Disease Research Fields Source Classification	Bacterial Apoptosis Bcl-2 Family MDM-2/p53 Glutathione Peroxidase SOD TNF Receptor Interleukin Related
Grosvenorine is an orally active flavonoid glycoside found in S. grosvenorii. Grosvenorine exhibits antibacterial, antioxidant and antiinflammation activities. Grosvenorine can induce apoptosis and increases anti-apoptotic *Bcl-2* protein expression and reduces pro-apoptotic P53 protein expression in gastric tissues. Grosvenorine enhances mucin/glycoprotein secretion, regulates gastric pH, and reduces gastric lesion incidence.Grosvenorine increases glutathione peroxidase, catalase, and SOD levels, reduces lipid peroxidation (MDA), and lowers TNF-α and IL-6 levels. Grosvenorine can be used for the researches of bacterial infection and Gastric ulcer ^[2].

HY-N2132

Flavokawain B 2 Publications Verification Flavokavain B	Structural Classification Chalcones Monophenols Flavonoids other families Classification of Application Fields Phenols Plants Disease Research Fields Source Classification Cancer	Apoptosis Caspase PARP Bcl-2 Family NF-κB PI3K Akt p38 MAPK MMP Reactive Oxygen Species (ROS)
Flavokawain B (Flavokavain B) is an orally active chalcone. Flavokawain B results in activation of caspase-9, -3 and -8, cleavage of PARP. Flavokawain B down-regulates *Bcl-2* with concomitant increase in Bax level. Flavokawain B inhibits NF-κB, PI3K/Akt and MAPK signaling pathway. Flavokawain B exhibits Apoptotic effects. Flavokawain B inhibits MMP-9 and promotes ROS generation. Flavokawain B inhibits multiple tumors and inflammation ^[2] .

HY-N1983

Caudatin 1 Publications Verification	Structural Classification Classification of Application Fields Asclepiadaceae Cynanchum otophyllum Schneid． Cynanchum auriculatum Royle ex Wight Plants Disease Research Fields Steroids Source Classification Cancer	Apoptosis Autophagy Reactive Oxygen Species (ROS) Mitochondrial Metabolism PARP Caspase Bcl-2 Family VEGFR FAK WDR5 p38 MAPK JNK PPAR
Caudatin is an orally active and brain-penetrant C-21 steroidal found in Cynanchum bungei decne with a variety of biological activities. Caudatin can inhibit cell proliferation, migration, invasion, cause cell phase arrest, induce apoptosis, autophagy, ROS prodution and loss of mitochondrial membrane potential. Caudatin activates PARP, caspase-3, -7, -9, upregulates pro-apoptotic Bad and Bax and downregulates anti-apoptotic *Bcl-2* and *Bcl-XL. Caudatin suppresses VEGF, FAK* phosphorylation, upregulates p21, p27, DR5 protein expression, activates the p38 MAPK, JNK and PPARα/TFEB-mediated autophagy-lysosomal signaling pathways. Caudatin can be used for the research of cancer, inflammation and neurological disease, such as glioma and Alzheimer's disease ^[2] .

HY-N6082

Rhein 8-O-β-D-Glucopyranoside 1 Publications Verification	Quinones Structural Classification Monophenols Rheum palmatum L. Classification of Application Fields Anthraquinones Polygonaceae Phenols Metabolic Disease Plants Disease Research Fields Source Classification	Apoptosis Bcl-2 Family Caspase TGF-beta/Smad Bacterial
Rhein 8-O-β-D-Glucopyranoside is an orally active glycoside found in Rhubarb. Rhein 8-O-β-D-Glucopyranoside attenuates high glucose-induced apoptosis, recovers altered lincRNA ANRIL and let-7a expression, reverses high glucose-altered *Bcl-2* and cleaved caspase-3 protein expression, and inhibits TGF-β1/Smad signaling. Rhein 8-O-β-D-Glucopyranoside accelerates Sennoside A (HY-N0365) metabolism, stimulates sennoside A purgative activity. Rhein 8-O-β-D-Glucopyranoside inhibits bacterial biofilm formation, suppresses its virulence gene expression, and exerts antibacterial activity. Rhein 8-O-β-D-Glucopyranoside can be used for the research of diabetic nephropathy, constipation, and infection ^[2] .

HY-N0392

Polygalasaponin F	Triterpenes Structural Classification Classification of Application Fields Terpenoids Polygalaceae Polygala japonica Houtt. Plants Inflammation/Immunology Disease Research Fields Source Classification	Toll-like Receptor (TLR) PI3K Akt NF-κB MDM-2/p53 Caspase MEK Bcl-2 Family p38 MAPK Mitophagy Reactive Oxygen Species (ROS) Apoptosis Calcium Channel
Polygalasaponin F is an orally active triterpenoid saponin monomer. Polygalasaponin F downregulates the expression of Bax, p53, caspase-3, NF-κB p65 and MEK1; restores and upregulates the expression of *Bcl-2; activates the PI3K/Akt* signaling pathway; inhibits the phosphorylation of p38 MAPK, nuclear translocation of NF-κB, TLR4-mediated signaling pathway, mitophagy (Mitophagy) and ROS production; enhances cell viability and suppresses apoptosis (Apoptosis). Polygalasaponin F maintains mitochondrial function, alleviates Ca ²⁺ overload, upregulates pCREB and BDNF, preserves cell viability and inhibits the release of inflammatory cytokines. Polygalasaponin F alleviates lung injury induced by influenza A H1N1 and cerebral ischemia-reperfusion injury. Polygalasaponin F is applicable to researches related to Parkinson's disease, cerebral ischemia, pneumonia induced by influenza A H1N1, stroke and Alzheimer's disease ^[2] .

HY-119931

2-Hydroxychalcone	Chalcones Monophenols Flavonoids Classification of Application Fields Phenols Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Bcl-2 Family Apoptosis NF-κB Parasite
2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB ^[2] .

HY-15464

(R)-(-)-Gossypol 3 Publications Verification AT-101; R-(-)-gossypol acetic acid	Malvaceae Classification of Application Fields Gossypium Phenols Plants Disease Research Fields Cancer Source Classification	Bcl-2 Family Autophagy
(R)-(-)-Gossypol (AT-101) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to *Bcl-2, Mcl-1* and *Bcl-xL* proteins with K_is of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.

HY-N0674A

Dehydrocorydaline chloride 40+ Cited Publications 13-Methylpalmatine chloride	Infection Alkaloids other families Classification of Application Fields Plants Isoquinoline Alkaloids Disease Research Fields Source Classification	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline chloride (13-Methylpalmatine chloride) is an alkaloid that regulates protein expression of Bax, *Bcl-2; activates caspase-7, caspase-8, and inactivates PARP* . Dehydrocorydaline chloride elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities ^[2]. Dehydrocorydaline chloride shows strong anti-malarial effects (IC₅₀?=38 nM), and low cytotoxicity (cell viability?>?90%) using P. falciparum 3D7 strain .

HY-N3405

Lariciresinol 1 Publications Verification	Structural Classification Human Gut Microbiota Metabolites Lignans Arabidopsis thaliana Phenylpropanoids Plants Brassicaceae Endogenous metabolite Source Classification	Glycosidase Bcl-2 Family Apoptosis TGF-β Receptor NF-κB Fungal
Lariciresinol is an orally active ingredient. Lariciresinol can be isolated from Arabidopsis thaliana. Lariciresinol inhibits α-glucosidase activity (IC₅₀ of 6.97 μM; K_i of 0.046 μM). Lariciresinol dereases *Bcl-2, upregulates Bax* and induces Apoptosis. Lariciresinol regulates TGF-β and NF-κB pathways. Lariciresinol has antitumor activity against liver cancer, gastric cancer, and breast cancer. Lariciresinol shows antifungal activity and anti-diabetic activity ^[2] .

HY-N6005

Methyl caffeate	Infection Structural Classification Classification of Application Fields Simple Phenylpropanols Phenols Polyphenols Solanum torvum Swartz Phenylpropanoids Solanaceae Plants Disease Research Fields Source Classification	Bacterial Fungal Apoptosis Bcl-2 Family
Methyl caffeate is a phenylpropanoid, antibacterial agent, and Apoptosis-inducing agent. Methyl caffeate can be isolated from the flowers of peach Prunus persica (L.). Methyl caffeate upregulates the expression of pro-apoptotic proteins Bid, Bax and p53, and downregulates the expression of anti-apoptotic protein *BCL-2. Methyl caffeate downregulates SASP* factors. Methyl caffeate enhances glucose-stimulated insulin secretion. Methyl caffeate inhibits the growth of Gram-positive bacteria, Gram-negative bacteria, fungi, and Mycobacterium tuberculosis strains. Methyl caffeate can be used in studies related to breast cancer, type 2 diabetes, and tuberculosis ^[2] .

HY-N2135

Puerarin 6''-O-Xyloside	Structural Classification Flavonoids other families Classification of Application Fields Phenols Polyphenols Plants Inflammation/Immunology Disease Research Fields Isoflavones Source Classification	Apoptosis Caspase Bcl-2 Family Tyrosinase
Puerarin 6''-O-Xyloside is one of the major iso-flavones found in P. lobata. Puerarin 6''-O-Xyloside inhibits cancer cells proliferation, induces apoptosis by upregulating cleaved caspase-3, 7, 9, Bax and downregulating *Bcl-2* levles and inhibits tumor growth in mice. Puerarin 6''-O-Xyloside has anti-osteoporotic activity in ovariectomized mice. Puerarin 6''-O-Xyloside inhibits mushroom tyrosinase with an IC₅₀ of 513.8 μM. Puerarin 6''-O-Xyloside can be used for the research of human lung carcinoma, osteoporosis, melanosis and melanomar ^[2] .

HY-N6850

Calenduloside E 1 Publications Verification	Triterpenes other families Classification of Application Fields Terpenoids Other Diseases Aralia elata (Miq.) Seem. Plants Endogenous metabolite Disease Research Fields Araliaceae Source Classification	Apoptosis Pyroptosis AMPK Bcl-2 Family JAK STAT Calcium Channel Interleukin Related TNF Receptor SOD Reactive Oxygen Species (ROS) PPAR
Calenduloside E is a pentacyclic triterpenoid saponin that can be extracted from the bark and roots of Aralia ovata, and has anti-inflammatory and anti-apoptotic activities. Calenduloside E alleviates atherosclerosis by regulating macrophage polarization, improves mitochondrial function by regulating the AMPK-SIRT3 pathway, and alleviates acute liver injury. In addition, Calenduloside E promotes the interaction between L-type calcium channels and *Bcl-2* related apoptosis genes, inhibits calcium overload, and alleviates myocardial ischemia/reperfusion injury. Calenduloside E also improves non-alcoholic fatty liver disease by regulating heat shock-dependent pathways, and inhibits ROS mediated JAK1-STAT3 pathways to reduce cellular inflammatory responses ^[2] .

HY-N13250

Hawthorn Extract	Cardiovascular Disease Classification of Application Fields Rosaceae Plants Disease Research Fields Source Classification	Apoptosis AMPK Elastase Bcl-2 Family Interleukin Related Caspase PI3K Akt SOD
Hawthorn Extract is an orally active hawthorn extract. Hawthorn Extract decreases Bax expression and increases *Bcl-2* expression in the aorta. Hawthorn Extract regulates the AMPK signaling pathway, induces apoptosis, enhances the hepatic antioxidant system, and ameliorates symptoms of liver injury, inflammation and cancer. Hawthorn Extract reduces plasma levels of pro-inflammatory factors, increases plasma levels of anti-inflammatory adiponectin, and alleviates atherosclerotic plaque lesions in the aorta. Hawthorn Extract improves symptoms associated with chronic heart failure . Hawthorn Extract inhibits FMLP-induced superoxide anion production, Elastase release, ILB₄ generation and calcium signaling in neutrophils, and also reduces LPS-induced cytokine production in neutrophils. Hawthorn Extract induces autophagy and inhibits the proliferation of intestinal stem cells. Hawthorn Extract can be used in research related to atherosclerosis, hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease, hepatocellular carcinoma, chronic heart failure and hypotension ^[2] .

HY-N0566

23-Hydroxybetulinic acid Anemosapogenin	Triterpenes Structural Classification other families Classification of Application Fields Terpenoids Plants Disease Research Fields Source Classification Cancer	Apoptosis Autophagy Bcl-2 Family Caspase Survivin p38 MAPK MMP
23-Hydroxybetulinic acid (Anemosapogenin) is an orally active triterpenoid with broad-spectrum anticancer activity. 23-Hydroxybetulinic acid reduces the levels of *Bcl-2* and survivin, elevates the level of Bax, promotes the cleavage/activation of caspase-3 and caspase-9, and induces apoptosis via the endogenous mitochondrial pathway involving cytochrome C release and mitochondrial membrane potential disruption. 23-Hydroxybetulinic acid arrests the cell cycle at S and G1 phases, inhibits cancer cell proliferation, blocks the MAPK signaling pathway, regulates *MMP2, and induces autophagic apoptosis by upregulating beclin-1. 23-Hydroxybetulinic acid inhibits the activity and efflux function of P-gp*, increases the intracellular accumulation of chemotherapeutic drugs, and synergistically enhances cytotoxicity with Doxorubicin (HY-15142). 23-Hydroxybetulinic acid inhibits the phosphorylation and nuclear translocation of STAT6, blocks M2 macrophage polarization, and reduces M2 macrophage-mediated apoptosis resistance of colon cancer cells. 23-Hydroxybetulinic acid can be used in related studies on chronic myeloid leukemia, hepatocellular carcinoma, sarcoma 180, multidrug-resistant breast cancer, leukemia, Doxorubicin-induced cardiotoxicity, and colorectal cancer ^[2] .

HY-N1157

Thevetiaflavone Apigenin-5-methyl ether	Flavonoids other families Flavones Phenols Polyphenols Plants Source Classification	Bcl-2 Family Caspase
Thevetiaflavone could upregulate the expression of *Bcl-2* and downregulate that of Bax and caspase-3.

HY-N3009

Secoxyloganin 1 Publications Verification	Cardiovascular Disease Structural Classification Caprifoliaceae Iridoids Classification of Application Fields Lonicera japonica Thunb. Terpenoids Plants Disease Research Fields Source Classification	Drug Derivative Apoptosis Bcl-2 Family
Secoxyloganin is an orally effective iridoid derivative. Secoxyloganin can be isolated from the flower buds of L. japonica. Secoxyloganin induces Apoptosis by inhibiting the expression of *Bcl-2*. Secoxyloganin potently inhibits the proliferation of breast cancer cells, while exerting weak activity against normal mammary epithelial cells. Secoxyloganin inhibits the decrease in tail vein blood flow associated with allergic reactions ^[2].

HY-N1423B

Glycocholic acid hydrate 3 Publications Verification	Structural Classification Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite Caspase G protein-coupled Bile Acid Receptor 1 LPL Receptor MDM-2/p53 Bcl-2 Family P-glycoprotein FXR Bacterial Apoptosis
Glycocholic acid hydrate is a bile acid derivative. Glycocholic acid hydrate downregulates MDR1, *Bcl-2, MRP1, MRP2* and FXR, upregulates Bax, p53, caspase-9, caspase-3, TGR5 and *S1PR2. Glycocholic acid hydrate inhibits multidrug resistance and efflux pumps, induces mitochondrial apoptosis*, and enhances chemosensitivity. Glycocholic acid hydrate modulates related bile acid receptor signaling. Glycocholic acid hydrate suppresses growth and conjugation of Enterobacteriaceae and increases their antibiotic susceptibility. Glycocholic acid hydrate can be used for the research of colon adenocarcinoma and cholangiocarcinoma (CCA) ^[2] .

HY-N0853A

Alisol A 24-acetate 1 Publications Verification Alisol A 24-monoacetate; Alisol A monoacetate	Triterpenes Structural Classification Alisma plantago-aquatica Linn. Classification of Application Fields Terpenoids Other Diseases Alismataceae Plants Disease Research Fields Source Classification	AMPK Carnitine Palmitoyltransferase (CPT) Acyltransferase Fatty Acid Synthase (FASN) Acetyl-CoA Carboxylase Bcl-2 Family PPAR Nuclear Factor of activated T Cells (NFAT) PI3K Akt PKA ERK Apoptosis Autophagy
Alisol A 24-acetate (Alisol A monoacetate) is an orally active derivative of protostane-type tetracyclic triterpenoid. Alisol A 24-acetate upregulates the expression of adiponectin, AMPKα, CPT1, and ACOX1; downregulates the expression of SREBP-1c, ACC, FAS, *Bcl-2, Bcl-xl, PPAR-γ, perilipin A, and NFATc1; inhibits the activity of PI3K/Akt/mTOR* and HMGR; and activates the PKA and ERK signaling pathways. Alisol A 24-acetate regulates cell apoptosis (apoptosis), autophagy (Autophagy, hepatic lipid accumulation, inflammatory response, neuroprotection, MRSA membrane integrity, and osteoclast differentiation. Alisol A 24-acetate can be used in research related to non-alcoholic fatty liver disease, nephrotoxicity, obesity, global cerebral ischemia-reperfusion injury, bacterial infection, and osteoporosis ^[2] .

HY-N1930

(-)-Hinesol Hinesol	Structural Classification Terpenoids Sesquiterpenes Plants Compositae Erythrina sigmoidea Hua	Apoptosis
(-)-Hinesol (Hinesol) is a potent anticancer agent. (-)-Hinesol induces apoptosis and cell cycle arrest at G0/G1 phase. (-)-Hinesol downregulates MEK/ERK pathway and NF-κB pathway and mediates theexpression of cyclin D1, Bax and Bcl-2. (-)-Hinesol has the potential for the research of non–small cell lung cancer .

HY-N0867

13-Oxyingenol-13-dodecanoate	Structural Classification Classification of Application Fields Terpenoids Gramineae Other Diseases Diterpenoids Leptochloa chinensis (Linn.) Nees Plants Disease Research Fields Source Classification	HIV ULK Bcl-2 Family
13-Oxyingenol-dodecanoate (13OD) is a tumor suppressor agent. 13-Oxyingenol-dodecanoate has anti-HIV-1 activity with EC₅₀ value of 33.7 nM .13-Oxyingenol-dodecanoate can induce the expression of ULK1 to effect mitochondrial dysfunction and cellular autophagy. 13-Oxyingenol-dodecanoate also increases the expression of BAX and suppresses the expression of *BCL-2* to effect apoptosis ^[2].

HY-N0674B

Dehydrocorydaline (hydroxyl) 40+ Cited Publications 13-Methylpalmatine (hydroxyl)	Alkaloids Corydalis yanhusuo W. T. Wang Plants Papaveraceae Source Classification	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline (13-Methylpalmatine) hydroxyl is an alkaloid that regulates protein expression of Bax, Bcl-2; activates caspase-7, caspase-8, and inactivates PARP. Dehydrocorydaline hydroxyl elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. Dehydrocorydaline hydroxyl shows strong anti-malarial effects (IC50=38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain.

HY-N4238

Dehydrocorydaline nitrate 40+ Cited Publications 13-Methylpalmatine nitrate	Infection Alkaloids other families Classification of Application Fields Plants Isoquinoline Alkaloids Disease Research Fields Source Classification	Bcl-2 Family Caspase PARP p38 MAPK Parasite Autophagy
Dehydrocorydaline nitrate (13-Methylpalmatine nitrate) is an alkaloid. Dehydrocorydaline regulates protein expression of Bax, *Bcl-2; activates caspase-7, caspase-8, and inactivates PARP* . Dehydrocorydaline nitrate elevates p38 MAPK activation. Anti-inflammatory and anti-cancer activities. ^[2]. Dehydrocorydaline nitrate shows strong anti-malarial effects (IC₅₀ =38 nM), and low cytotoxicity (cell viability > 90%) using P. falciparum 3D7 strain .

HY-N0292R

Oleuropein (Standard)	Structural Classification Iridoids Canarium album (Lour.) Rauesch. Terpenoids Phenols Polyphenols Plants Burseraceae Source Classification	Cytochrome P450 Reference Standards PPAR Apoptosis
Oleuropein (Standard) is the analytical standard of Oleuropein. This product is intended for research and analytical applications. Oleuropein, found in olive leaves and oil, exerts antioxidant, anti-inflammatory and anti-atherogenic effects through direct inhibition of PPARγ transcriptional activity . Oleuropein induces apoptosis in breast cancer cells via the p53-dependent pathway and through the regulation of Bax and Bcl2 genes. Oleuropein also inhibits aromatase ^[2].

HY-W674241A

4-Ethylphenyl sulfate sodium	Structural Classification Natural Products Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Apoptosis Bcl-2 Family Reactive Oxygen Species (ROS)
4-Ethylphenyl sulfate sodium is an orally active and brain-penetrant gut microbial metabolite. 4-Ethylphenyl sulfate sodium downregulates *Bcl2* expression, upregulates Bax expression, and induces cancer cell apoptosis via the endogenous apoptotic pathway. 4-Ethylphenyl sulfate sodium induces G2/M cell cycle arrest and reactive oxygen species (ROS) production. 4-Ethylphenyl sulfate sodium impairs oligodendrocyte maturation, reduces oligodendrocyte-neuron interactions, decreases axonal myelination levels, and shifts the oligodendrocyte population toward immature precursor cells. 4-Ethylphenyl sulfate sodium alters brain region-specific neural activity and functional connectivity in mice, and correlates with anxiety-like behaviors in mice ^[2].

Species:	Human (14) Rat (1) Mouse (4)
Tag:	His (16) Tag Free (2) Myc (1) GST (1)
Source:	E. coli Cell-free (2) P. pastoris (1) E. coli (16)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P72101

	BCL2 Protein, Mouse (His) 1 Publications Verification Bcl2; Bcl-2; Apoptosis regulator Bcl-2	Mouse	E. coli
	BCL2 protein crucially regulates cell death by controlling mitochondrial membrane permeability. It interacts with caspases in a feedback loop, inhibiting their activity. BCL2 prevents cytochrome c release from mitochondria and binds to apoptosis-activating factor (APAF-1). BCL2 Protein, Mouse (His) is the recombinant mouse-derived BCL2 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P7537

	BCL2 Protein, Human (His) rHuApoptosis Regulator Bcl-2, His; B-cell Lymphoma 2; Apoptosis Regulator Bcl-2	Human	E. coli
	BCL2 Protein regulates the mitochondrial membrane permeability, and inhibits the caspase activity, thereby suppressing the apoptosis in various cell types. BCL2 Protein interacts with BECN1 and AMBRA1, and inhibits the autophagy. BCL2 Protein, Human (His) is the human-derived resombinant BCL2 Protein that is expressed in in E. coli with a His tag at the C-terminus.

HY-P702223

	BCL2 Protein, Rat (Cell-Free, His) Apoptosis regulator Bcl-2	Rat	E. coli Cell-free
	The BCL2 protein is critical for inhibiting apoptosis in different cellular systems and regulates cell death by controlling mitochondrial membrane permeability. BCL2 operates in a feedback loop with caspases, inhibiting caspase activity by preventing cytochrome c release and binding to apoptosis-activating factor (APAF-1). BCL2 Protein, Rat (Cell-Free, His) is the recombinant rat-derived BCL2 protein, expressed by E. coli Cell-free , with N-10*His labeled tag.

HY-P76165

	BCL2L12 Protein, Human (GST) Bcl-2-like protein 12; Bcl2-L-12; Bcl-2-related proline-rich protein; BPR	Human	E. coli
	BCL2-like 12 (BCL2L12) is a new member of the apoptosis-related BCL2 gene family. BCL2L12 contains a highly conserved BH2 domain, a BH3-like domain and a proline-rich region. BCL2L12 exhibits pro-apoptotic activity in breast tumor and gastric cancer. BCL2L12 is an inhibitor of post-mitochondrial effector caspase activation, as it binds to and inhibits caspase-7 and upregulates the caspase-3-specific inhibitor 伪B-crystallin (CRYAB). BCL2L12 attenuates endogenous p53-directed transcriptomic changes after genotoxic stress and inhibits p53-dependent DNA damage-induced apoptosis. BCL2L12 Protein, Human (GST) is the recombinant human-derived BCL2L12 protein, expressed by E. coli , with N-GST labeled tag.

HY-P75590

	BCL2A1 Protein, Human (His) Bcl-2-related protein A1; Protein BFL-1; BCL2L5; BFL1; GRS; HBPA1	Human	E. coli
	The BCL2A1 protein plays a critical role in resisting apoptosis triggered by IL-3 deprivation, suggesting its importance in the response of hematopoietic cells to external signals and may be involved in protecting endothelial cell survival during infection. It also inhibits serum starvation-induced apoptosis in mammary epithelial cells (HC11). BCL2A1 Protein, Human (His) is the recombinant human-derived BCL2A1 protein, expressed by E. coli , with N-His labeled tag.

HY-P7650

	Bcl-2-like protein 1 Protein, Human (His) rHuBcl-2-like protein 1, His; Bcl-2-Like Protein 1; Apoptosis Regulator Bcl-X; BCL2L;	Human	E. coli
	Bcl-2-like protein 1 Protein, Human (His) is an important apoptosis regulating gene that codes for both an anti-apoptotic (Bcl-x_L) and a pro-apoptotic (Bcl-x_S) splice variant.

HY-P7653

	Bcl-2-like protein 2 Protein, Human (His) rHuBcl-2-like protein 2, His; Bcl-2-Like Protein 2; Apoptosis Regulator Bcl-W; BCL2L2; KIAA0271	Human	E. coli
	Bcl-2-like protein 2 is a key regulator that promotes cell survival and prevents dexamethasone-induced apoptosis, which is critical for postmitotic Sertoli cells. It inhibits BAX, emphasizing its role in survival mechanisms. Bcl-2-like protein 2 Protein, Human (His) is the recombinant human-derived Bcl-2-like protein 2 protein, expressed by E. coli , with C-6*His labeled tag.

HY-P72846

	Bcl-XL Protein, Mouse (His, solution) Bcl-2-like protein 1; Bcl2-L-1; Apoptosis regulator Bcl-X; Bclx	Mouse	E. coli
	Bcl-XL protein forms heterodimers with BAX, BAK, or BCL2, but its antiapoptotic activity does not require heterodimerization with BAX. Bcl-XL Protein, Mouse (His, solution) is the recombinant mouse-derived Bcl-XL protein, expressed by E. coli , with C-His labeled tag.

HY-P72846A

	Bcl-XL Protein, Mouse (C-His) Bcl-2-like protein 1; Bcl2-L-1; Apoptosis regulator Bcl-X; Bclx	Mouse	E. coli
	Bcl-XL protein forms heterodimers with BAX, BAK, or BCL2, but its antiapoptotic activity does not require heterodimerization with BAX. Bcl-XL Protein, Mouse (C-His) is the recombinant mouse-derived Bcl-XL, expressed by E. coli , with C-6*His labeled tag.

HY-P75473

	BMF Protein, Human (His) Bcl-2-modifying factor; BMF	Human	E. coli
	BMF proteins may play a key role in apoptosis, with isoform 1 being the major promoter. It interacts with anti-apoptotic proteins (including MCL1, BCL2, BCL2L1/BCL-Xl, BCL2A1 and BCL2L2/BCL-w), suggesting involvement in the regulatory network of cell death. BMF Protein, Human (His) is the recombinant human-derived BMF protein, expressed by E. coli , with N-His labeled tag.

HY-P7651

	Bax Protein, Human (His) rHuBCL2L4, His; Apoptosis Regulator BAX; Bcl-2-Like Protein 4; BCL2L4; BAX	Human	E. coli
	Bax Protein, Human (His) suppresses tumorigenesis and stimulates apoptosis. BCL2L4 (BAX) is the proapoptotic members of the Bcl-2 family that are ubiquitously expressed in different tissues.

HY-P700303

	Bcl-2-like Protein 11 Protein, Human (His) rHuBcl-2-like Protein 11, His; Bcl-2-like protein 11; BIML	Human	E. coli
	Bcl-2-like protein 11 (BCL2L11), despite its classification, does not interact with humanin. This unique feature distinguishes BCL2L11 from expected protein-protein interactions typically associated with Bcl-2 family members. Bcl-2-like Protein 11 Protein, Human (His) is the recombinant human-derived Bcl-2-like Protein 11 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P702614

	Bax Protein, Human (Cell-Free, His) rHuBCL2L4, His; Apoptosis Regulator BAX; Bcl-2-Like Protein 4; BCL2L4; BAX	Human	E. coli Cell-free
	Bax Protein, Human (Cell-Free, His) is the recombinant human-derived Bax, expressed by E. coli Cell-free, with N-10*His labeled tag.

HY-P703089

	BAK1 Protein, Human BAK; BCL2L7; CDN1	Human	E. coli
	BAK1 Protein, Human is the recombinant human-derived BAK1, expressed by E. coli, with tag free labeled tag.

HY-P702954

	BAD Protein, Human (His, Myc) BBC6; BCL2L8	Human	E. coli
	BAD Protein, Human (His, Myc) is the recombinant human-derived BAD, expressed by E.coli, with His, Myc labeled tag.

HY-P71848

	BAG-3 Protein, Mouse (P.pastoris, His) Bag3; Bis; MNCb-2243BAG family molecular chaperone regulator 3; BAG-3; Bcl-2-associated athanogene 3; Bcl-2-binding protein Bis	Mouse	P. pastoris
	The BAG-3 protein is a co-chaperone of HSP70 and HSC70, acting as a nucleotide exchange factor to promote the release of ADP from these partners, thus triggering substrate release. BAG-3 Protein, Mouse (P.pastoris, His) is the recombinant mouse-derived BAG-3 protein, expressed by P. pastoris , with N-His labeled tag.

HY-P7647

	BAG-2 Protein, Human (His) rHuBAG2, His; BAG Family Molecular Chaperone Regulator 2; BAG-2; Bcl-2-Associated Athanogene 2; BAG2	Human	E. coli
	BAG2 Protein, Human (His) promotes tumorigenesis through enhancing mutant p53 protein levels and function. BAG2 is a target of the c-Myc gene and is involved in cellular senescence via the p21CIP1 pathway.

HY-P7670

	BNIP3/NIP3 Protein, Human (His) rHuBNIP3, His; BNIP3; NIP3; BCL2/Adenovirus E1B 19 kDa Protein-Interacting Protein 3	Human	E. coli
	BNIP3/NIP3 Protein, Human (His) expresses in E. coliwith a His tag. BNIP3 belongs to the Bcl-2 protein family that regulates programmed cell death.

HY-P75471

	BNIP3L Protein, Human BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like; NIP3L; BNIP3L; BNIP3A; BNIP3H; NIX	Human	E. coli
	BNIP3L, a pro-apoptotic member of the Bcl-2 family, possesses a BH3 domain and binds to Bcl-2. It directly targets mitochondria, inducing apoptotic changes like membrane potential loss and cytochrome c release. With ubiquitous expression, especially in fat and ovary, the gene suggests involvement in diverse physiological processes across multiple organs, emphasizing its potential significance. BNIP3L Protein, Human is the recombinant human-derived BNIP3L protein, expressed by E. coli , with tag free.

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HY-15531S

Venetoclax-d8
Venetoclax-d₈ is deuterium labeled Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a K_i of less than 0.01 nM. Venetoclax induces autophagy ^[2] .

HY-N1423S

Glycocholic acid-d4

Glycocholic acid-d₄ is the deuterium labeled Glycocholic acid (HY-N1423). Glycocholic acid is a bile acid derivative. Glycocholic acid downregulates MDR1, Bcl-2, MRP1, MRP2 and FXR, upregulates Bax, p53, caspase-9, caspase-3, TGR5 and S1PR2. Glycocholic acid inhibits multidrug resistance and efflux pumps, induces mitochondrial apoptosis, and enhances chemosensitivity. Glycocholic acid modulates related bile acid receptor signaling. Glycocholic acid suppresses growth and conjugation of Enterobacteriaceae and increases their antibiotic susceptibility. Glycocholic acid can be used for the research of colon adenocarcinoma and cholangiocarcinoma (CCA).

HY-B0011S

Docetaxel-d9
Docetaxel-d₉ is the deuterium labeled Docetaxel. Docetaxel (RP-56976) is a microtubule?depolymerization inhibitor, with an IC₅₀ of 0.2 μM. Docetaxel attenuates the effects of?bcl-2 and bcl-xL gene expression. Docetaxel arrests the cell cycle at G2/M and leads to cell apoptosis. Docetaxel has anti-cancer activity .

HY-10087S

Navitoclax-d8 1 Publications Verification
Navitoclax-d₈ is the deuterium labeled Navitoclax. Navitoclax (ABT-263) is a potent and orally active Bcl-2 family protein inhibitor that binds to multiple anti-apoptotic Bcl-2 family proteins, such as Bcl-xL, Bcl-2 and Bcl-w, with a Ki of less than 1 nM .

HY-15531S1

Venetoclax-d6
Venetoclax-d₆ (ABT-199-d₆) is deuterium labeled Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable *Bcl-2* inhibitor with a K_i of less than 0.01 nM. Venetoclax induces autophagy ^[2] .

HY-N1423S1

Glycocholic acid-d5

Glycocholic acid-d₅ is the deuterium labeled Glycocholic acid (HY-N1423). Glycocholic acid is a bile acid derivative. Glycocholic acid downregulates MDR1, Bcl-2, MRP1, MRP2 and FXR, upregulates Bax, p53, caspase-9, caspase-3, TGR5 and S1PR2. Glycocholic acid inhibits multidrug resistance and efflux pumps, induces mitochondrial apoptosis, and enhances chemosensitivity. Glycocholic acid modulates related bile acid receptor signaling. Glycocholic acid suppresses growth and conjugation of Enterobacteriaceae and increases their antibiotic susceptibility. Glycocholic acid can be used for the research of colon adenocarcinoma and cholangiocarcinoma (CCA).

HY-B0011AS

Docetaxel-d5 trihydrate

Docetaxel-d₅ (trihydrate) is the deuterium labeled Docetaxel (Trihydrate). Docetaxel Trihydrate (RP-56976 Trihydrate) is an antineoplastic agent and inhibits microtubule?depolymerization with an IC₅₀ value of 0.2 μM . Docetaxel Trihydrate is a semisynthetic analog of taxol and attenuates the effects of?bcl-2?and?bcl-xL?gene expression. Docetaxel Trihydrate arrests the cell cycle at G2/M and leads to cell apoptosis .

HY-50907S

ABT-737-d8

ABT 737-d₈ is the deuterium labeled ABT-737. ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-x_L and Bcl-w inhibitor with EC₅₀s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 induces autophagy and has the potential for acute myeloid leukemia (AML) research ^[2] .

HY-18628S

UMI-77-d4
UMI-77-d₄ is the deuterium labeled UMI-77. UMI-77 is a selective Mcl-1 inhibitor, which shows high binding affinity to Mcl-1 (IC50=0.31 μM). UMI-77 binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM, showing selectivity over other members of anti-apoptotic Bcl-2 members.

HY-N0361S

Dihydrocapsaicin-d3

Dihydrocapsaicin-d₃ is the deuterium labeled Dihydrocapsaicin (HY-N0361) . Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat ^[2] .

HY-W754548

Glycocholic acid-13C2,d4

Glycocholic acid- ¹³C₂,d₄ is the deuterium labeled and ¹³C-labeled Glycocholic acid (HY-N1423). Glycocholic acid is a bile acid derivative. Glycocholic acid downregulates MDR1, Bcl-2, MRP1, MRP2 and FXR, upregulates Bax, p53, caspase-9, caspase-3, TGR5 and S1PR2. Glycocholic acid inhibits multidrug resistance and efflux pumps, induces mitochondrial apoptosis, and enhances chemosensitivity. Glycocholic acid modulates related bile acid receptor signaling. Glycocholic acid suppresses growth and conjugation of Enterobacteriaceae and increases their antibiotic susceptibility. Glycocholic acid can be used for the research of colon adenocarcinoma and cholangiocarcinoma (CCA).

HY-W713297

Moroxydine hydrochloride-d8

Moroxydine hydrochloride-d₈ (ABOB hydrochloride-d₈) is the deuterium labeled Moroxydine (ABOB) hydrochloride (HY-B0420A). Moroxydine hydrochloride is a broad-spectrum agent with multi-antiviral activities against DNA and RNA viruses, including influenza virus, herpes simplex, varicella zoster, measles, mumps disease, hepatitis C virus, etc. Moroxydine hydrochloride exhibits excellent antiviral activity and shows low cytotoxicity to cells infected by dsRNA viruses (grass carp reovirus, GCRV) and large DNA viruses (giant salamander iridovirus, GSIV). Moroxydine hydrochloride blocks the GCRV-induced cytopathic effects and eliminates nucleocapsids in ctenopharyngodon idella kidney (CIK) cells to keep the normal morphological structure. Moroxydine hydrochloride significantly inhibits the apoptosis, the caspase 3 activity, Bax expression and down-regulates Bcl-2 levels ^[1][2][3].

Host:	Mouse (21) Rabbit (37)
Reactivity:	Human (56) Rat (32) Mouse (35) Monkey (4) Rabbit (2) Chicken (2) human (1)
Application:	IHC-P (37) ICC/IF (35) IF-Tissue (4) IP (18) IHC-F (7) WB (50) FC (22) ELISA (21)
Isotype:	IgG (37) IgG1 (8) IgG/Kappa (2) IgG2a (6) IgG2b (4)
Conjugation:	Non-conjugated (58)
Clonality:	Polyclonal (1) polyclonal (1) Monoclonal (40) Recombinant (17)
Modification:	Phosphorylated (1) Unmodified (43)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P86421

	Bcl-2 Antibody (YA6113) BCL2; Apoptosis regulator Bcl-2	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Bcl-2 Antibody (YA6113) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bcl-2.

HY-P85653

	Bcl-2 Antibody (YA5345) BCL2; Apoptosis regulator Bcl-2	WB, ICC/IF, ELISA	Human, Mouse, Rat
	Bcl-2 Antibody (YA5345) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Bcl-2.

HY-P86688

	Bcl-2 Antibody (YA6380) Apoptosis regulator Bcl 2; Apoptosis regulator Bcl2; AW986256; B cell CLL/lymphoma 2; B cell leukemia/lymphoma 2; B cell lymphoma 2; Bcl 2; Bcl-2; Bcl2; BCL2 protein; C430015F12Rik; D630044D05Rik; D830018M01Rik; Leukemia/lymphoma, B-cell, 2; Oncogene B-cell leukemia 2; BCL2_HUMAN.	WB, IHC-P, IHC-F, IF-Tissue	Human
	Bcl-2 Antibody (YA6380) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bcl-2.

HY-P86712

	Bcl-2 Antibody (YA6404) Apoptosis regulator Bcl 2; Apoptosis regulator Bcl2; AW986256; B cell CLL/lymphoma 2; B cell leukemia/lymphoma 2; B cell lymphoma 2; Bcl 2; Bcl-2; Bcl2; BCL2 protein; C430015F12Rik; D630044D05Rik; D830018M01Rik; Leukemia/lymphoma, B-cell, 2; Oncogene B-cell leukemia 2; BCL2_HUMAN.	WB, ICC/IF, FC	Human
	Bcl-2 Antibody (YA6404) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to Bcl-2.

HY-P80029

	Bcl-2 Antibody (YA589) 4 Publications Verification	WB, ICC/IF, IHC-P, FC	Human, Mouse, Rat
	Bcl-2 Antibody (YA589) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bcl-2.

HY-P86712A

	Bcl-2 Antibody (YA6404)(PBS only) Apoptosis regulator Bcl 2; Apoptosis regulator Bcl2; AW986256; B cell CLL/lymphoma 2; B cell leukemia/lymphoma 2; B cell lymphoma 2; Bcl 2; Bcl-2; Bcl2; BCL2 protein; C430015F12Rik; D630044D05Rik; D830018M01Rik; Leukemia/lymphoma, B-cell, 2; Oncogene B-cell leukemia 2; BCL2_HUMAN.	WB, ICC/IF, FC	Human
	Bcl-2 Antibody (YA6404) is a Mouse-derived and non-conjugated IgG monoclonal antibody, targeting to Bcl-2.

HY-P80566

	Bcl-2 Antibody (YA590) Maximum Cited Publications 10 Publications Verification BCL2; Apoptosis regulator Bcl-2	WB, IHC-P	Human, Mouse
	Bcl-2 Antibody (YA590) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bcl-2.

HY-P80565

	Bcl-2 Antibody (YA824) BCL2; Apoptosis regulator Bcl-2	WB	Human, Rat, Mouse
	Bcl-2 Antibody (YA824) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Bcl-2.

HY-P83740

	Bcl-2 Antibody (YA3469) BCL2; Apoptosis regulator Bcl-2	WB, IHC-P, IHC-F, ICC/IF	Human, Chicken
	Bcl-2 Antibody (YA3469) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Bcl-2.

HY-P80565A

	Bcl-2 Antibody (YA824)(PBS only) BCL2; Apoptosis regulator Bcl-2	WB	Human, Rat, Mouse
	Bcl-2 Antibody (YA824) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Bcl-2.

HY-P80566A

	Bcl-2 Antibody (YA590)(PBS only) BCL2; Apoptosis regulator Bcl-2	WB, IHC-P	Human, Mouse
	Bcl-2 Antibody (YA590) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bcl-2.

HY-P83740A

	Bcl-2 Antibody (YA3469)(PBS only) BCL2; Apoptosis regulator Bcl-2	WB, IHC-P, IHC-F, ICC/IF	Human, Chicken
	Bcl-2 Antibody (YA3469) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Bcl-2.

HY-P810631

	*Phospho-Bcl-2* (Ser70) Antibody (YA9893)** BCL2; Apoptosis regulator Bcl-2	WB, ICC/IF, FC	Human
	Phospho-Bcl-2 (Ser70) Antibody (YA9893) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-Bcl-2 (Ser70).

HY-P810519

	BMF Antibody Bcl2 modifying factor, Bmf	WB, IHC-P	Human, Mouse, Rat
	BMF Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to BMF.

HY-P82995

	Bcl2 L14 Antibody (YA2740) BCLG	WB, ICC/IF, IP	Human, Mouse, Rat
	Bcl2 L14 Antibody (YA2740) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bcl2 L14.

HY-P82648

	BPR Antibody (YA2393) BCL2 like 12; BCL2L12; BPR	WB, IHC-P, ICC/IF, IP, FC	Human
	BPR Antibody (YA2393) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BPR.

HY-P82691

	BMF Antibody (YA2436) Bcl2 modifying factor; Bmf	WB, FC	Human, Mouse, Rat
	BMF Antibody (YA2436) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BMF.

HY-P85607

	BAG1 Antibody (YA5299) Bag 1; BAG family molecular chaperone regulator 1; BAG-1; BAG1; BAG1_HUMAN; BCL 2 Associated Athanogene 1; BCL 2 associated athanogene; BCL 2 binding athanogene 1; Bcl-2-associated athanogene 1; BCL2 associated athanogene 1; BCL2 associated athanogene; Glucocorticoid receptor-associated protein RAP46; HAP1; Haptoglobin; RAP 46; RAP46.	WB	Human, Mouse
	BAG1 Antibody (YA5299) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to BAG1.

HY-P82995A

	Bcl2 L14 Antibody (YA2740)(PBS only) BCLG	WB, ICC/IF, IP	Human, Mouse, Rat
	Bcl2 L14 Antibody (YA2740) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bcl2 L14.

HY-P86533

	Bad Antibody (YA6225) BAD; BBC6; BCL2L8; Bcl2 antagonist of cell death; BAD; Bcl-2-binding component 6; Bcl-2-like protein 8; Bcl2-L-8; Bcl-XL/Bcl-2-associated death promoter	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Bad Antibody (YA6225) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bad.

HY-P83354

	Phospho-Bad (Ser112) Antibody (YA3099) BAD; BBC6; BCL2L8; Bcl2 antagonist of cell death; BAD; Bcl-2-binding component 6; Bcl-2-like protein 8; Bcl2-L-8; Bcl-XL/Bcl-2-associated death promoter	WB, IP	Human, Mouse, Rat
	Phospho-Bad (Ser112) Antibody (YA3099) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-Bad (Ser112).

HY-P82998

	Bcl2 A1 Antibody (YA2743) BCL2A1; ACC-1; ACC-2; Bcl-2-like protein 5; Bcl-2-related protein A1; BCL2-related protein A1; BFL1; Bcl2-L-5; BCL2L5; GRS; HBPA1; Protein BFL-1; Protein GRS	WB, IHC-P, FC	Human, Mouse, Rat
	Bcl2 A1 Antibody (YA2743) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bcl2 A1.

HY-P80563

	Bak Antibody 1 Publications Verification BAK1; BAK; BCL2L7; CDN1; Bcl-2 homologous antagonist/killer; Apoptosis regulator BAK; Bcl-2-like protein 7; Bcl2-L-7	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse
	Bak Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Bak.

HY-P86353

	Bak Antibody (YA6045) BAK1; BAK; BCL2L7; CDN1; Bcl-2 homologous antagonist/killer; Apoptosis regulator BAK; Bcl-2-like protein 7; Bcl2-L-7	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Bak Antibody (YA6045) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bak.

HY-P83584

	BNIP1 Antibody (YA3329) BCL2 adenovirus E1B 19kD interacting protein 1; BNIP1; Nip1; sec20; SEC20L; Transformation-related gene 8 protein; TRG8; Vesicle transport protein SEC20	WB, IHC-P	Human, Mouse, Rat
	BNIP1 Antibody (YA3329) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BNIP1.

HY-P86326

	Bim Antibody (YA6018) BCL2L11; BIM; Bcl-2-like protein 11; Bcl2-L-11; Bcl2-interacting mediator of cell death	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Bim Antibody (YA6018) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bim.

HY-P80027

	Bax Antibody (YA825) 3 Publications Verification Apoptosis regulator BAX; BAX; Bcl-2-like protein 4; BCL2-associated X protein; Bcl2-L-4; BCL2L4	WB, IHC-P	Human, Mouse, Rat
	Bax Antibody (YA825) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Bax.

HY-P80564

	Bax Antibody (YA826) Apoptosis regulator BAX; BAX; Bcl-2-like protein 4; BCL2-associated X protein; Bcl2-L-4; BCL2L4	WB	Human, Monkey
	Bax Antibody (YA826) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Bax.

HY-P81614

	Bcl-XL Antibody (YA1359) BCL2L1; BCL2L; BCLX; Bcl-2-like protein 1; Bcl2-L-1; Apoptosis regulator Bcl-X	FC, ELISA	Human
	Bcl-XL Antibody (YA1359) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bcl-XL.

HY-P86554

	Bcl-XL Antibody (YA6246) BCL2L1; BCL2L; BCLX; Bcl-2-like protein 1; Bcl2-L-1; Apoptosis regulator Bcl-X	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Bcl-XL Antibody (YA6246) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bcl-XL.

HY-P80030A

	Bcl-XL Antibody (YA588)(PBS only) BCL2L, BCLX, BCL2L1, Bcl-2-like protein 1, Bcl2-L-1, Apoptosis regulator Bcl-X	WB, ICC/IF, IHC-P, FC, IP	Human
	Bcl-XL Antibody (YA588)(PBS only) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bcl-XL.

HY-P80564A

	Bax Antibody (YA826)(PBS only) Apoptosis regulator BAX; BAX; Bcl-2-like protein 4; BCL2-associated X protein; Bcl2-L-4; BCL2L4	WB	Human, Monkey
	Bax Antibody (YA826) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Bax.

HY-P86515

	Bax Antibody (YA6207) BAX; BCL2L4; Apoptosis regulator BAX; Bcl-2-like protein 4; Bcl2-L-4	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Bax Antibody (YA6207) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bax.

HY-P84812

	BCL2L10 Antibody (YA4509) Boo; Diva; BCL-B; bcl2-L-10	IHC-P, ICC/IF, FC, ELISA	Human
	BCL2L10 Antibody (YA4509) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to BCL2L10.

HY-P84812A

	BCL2L10 Antibody (YA4509)(PBS only) Boo; Diva; BCL-B; bcl2-L-10	IHC-P, ICC/IF, FC, ELISA	Human
	BCL2L10 Antibody (YA4509) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to BCL2L10.

HY-P86177

	MCL1 Antibody (YA5869) MCL1; BCL2L3; Induced myeloid leukemia cell differentiation protein Mcl-1; Bcl-2-like protein 3; Bcl2-L-3; Bcl-2-related protein EAT/mcl1; mcl1/EAT	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	MCL1 Antibody (YA5869) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MCL1.

HY-P85269

	MCL1 Antibod (YA4961) MCL1; BCL2L3; Induced myeloid leukemia cell differentiation protein Mcl-1; Bcl-2-like protein 3; Bcl2-L-3; Bcl-2-related protein EAT/mcl1; mcl1/EAT	WB, ICC/IF, IP, FC	Human, Mouse, Rat
	MCL1 Antibody (YA4961) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to MCL1.

HY-P84709

	BCL2L2 Antibody (YA4406) BCLW; BCL-W; PPP1R51; BCL2-L-2	IHC-P, ICC/IF, FC, ELISA	Human
	BCL2L2 Antibody (YA4406) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to BCL2L2.

HY-P87568

	BCL2L15 Antibody (YA7252)	IHC-P, IHC-F, IF-Tissue, FC, ICC/IF
	BCL2L15 Antibody (YA7252) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BCL2L15.

HY-P84709A

	BCL2L2 Antibody (YA4406)(PBS only) BCLW; BCL-W; PPP1R51; BCL2-L-2	IHC-P, ICC/IF, FC, ELISA	Human
	BCL2L2 Antibody (YA4406) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to BCL2L2.

HY-P84506

	Bax Antibody (YA4203) BCL2L4	WB, IHC-P, FC, ELISA	Human, Mouse, Rat, Rabbit, Monkey
	Bax Antibody (YA4203) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Bax.

HY-P82544

	Bok Antibody (YA2289) BOKL; BCL2L9	WB, FC	Human, Mouse, Rat
	Bok Antibody (YA2289) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bok.

HY-P84506A

	Bax Antibody (YA4203)(PBS only) BCL2L4	WB, IHC-P, FC, ELISA	Human, Mouse, Rat, Rabbit, Monkey
	Bax Antibody (YA4203) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to Bax.

HY-P82544A

	Bok Antibody (YA2289)(PBS only) BOKL; BCL2L9	WB, FC	Human, Mouse, Rat
	Bok Antibody (YA2289) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bok.

HY-P84615

	Bak Antibody (YA4312) BAK; CDN1; BCL2L7; BAK-LIKE	IHC-P, FC, ELISA	Human
	Bak Antibody (YA4312) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Bak.

HY-P86461

	BAG3 Antibody (YA6153) BAG3; BIS; BAG family molecular chaperone regulator 3; BAG-3; Bcl-2-associated athanogene 3; Bcl-2-binding protein Bis; Docking protein CAIR-1	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	BAG3 Antibody (YA6153) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BAG3.

HY-P82495

	BAG3 Antibody (YA2240) BAG3; BIS; BAG family molecular chaperone regulator 3; BAG-3; Bcl-2-associated athanogene 3; Bcl-2-binding protein Bis; Docking protein CAIR-1	WB	Human, Rat
	BAG3 Antibody (YA2240) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to BAG3.

HY-P84615A

	Bak Antibody (YA4312)(PBS only) BAK; CDN1; BCL2L7; BAK-LIKE	IHC-P, FC, ELISA	Human
	Bak Antibody (YA4312) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to Bak.

HY-P86374

	Beclin 1 Antibody (YA6066) Beclin-1 (Coiled-coil myosin-like BCL2-interacting protein) (Protein GT197)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Beclin 1 Antibody (YA6066) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Beclin 1.

HY-P86329

	PUMA Antibody (YA6021) BBC3; PUMA; Bcl-2-binding component 3; JFY-1; p53 up-regulated modulator of apoptosis	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	PUMA Antibody (YA6021) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PUMA.

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Cat. No.	Product Name		Classification

HY-N0171A

Beta-Sitosterol (purity>98%) 15+ Cited Publications β-Sitosterol (purity>98%); 22,23-Dihydrostigmasterol (purity>98%)		Cholesterol
Beta-Sitosterol (purity>98%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, TNF-α, IL-1β, and NF-κB p65 and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating caspase-3, caspase-8, and caspase-9, mediating PARP inactivation, MMP loss, altered *Bcl-2-Bax* ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc ^[2] .

HY-N0171

Beta-Sitosterol (purity>80%) Maximum Cited Publications 22 Publications Verification		Cholesterol
Beta-Sitosterol (purity≥80%) is orally active. Beta-Sitosterol exhibits multiple activities, including anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, antioxidant enzyme, and analgesic. Beta-Sitosterol inhibits inflammation and impaired adipogenesis in bovine mammary epithelial cells by reducing levels of ROS, TNF-α, IL-1β, and NF-κB p65 and restoring the activity of the HIF-1α/mTOR signaling pathway. Beta-Sitosterol induces apoptosis in cancer cells through ROS-mediated mitochondrial dysregulation and p53 activation. Beta-Sitosterol exerts its anticancer effects in cancer cells by activating caspase-3, caspase-8, and caspase-9, mediating PARP inactivation, MMP loss, altered *Bcl-2-Bax* ratio, and cytochrome c release. Beta-Sitosterol modulates macrophage polarization and reduces rheumatoid inflammation in mice. Beta-Sitosterol inhibits tumor growth in multiple mouse cancer models. Beta-Sitosterol can be used in the research of arthritis, lung cancer, breast cancer and other cancers, diabetes, etc ^[2] .

HY-126437

Poly-L-lysine hydrobromide (MW 30000-70000) 1 Publications Verification		Polymers
Poly-L-lysine hydrobromide (MW 30000-70000) is a water-soluble synthetic polypeptide. Poly-L-lysine hydrobromide (MW 30000-70000) downregulates *Bcl-2* and upregulates Bax and p53 proteins. Poly-L-lysine hydrobromide (MW 30000-70000) promotes Apoptosis and reduces VEGF expression. Poly-L-lysine hydrobromide (MW 30000-70000) shows anticancer activity against a variety of tumors. Poly-L-lysine hydrobromide (MW 30000-70000) can also be used as a coating material ^[2] .

HY-147081

AS 1411 2 Publications Verification AGRO-100		Aptamers
AS 1411 (AGRO-100) is an oligonucleotide aptamer targeting nucleoproteins. AS 1411 inhibits tumor cell proliferation by affecting the activity of nucleoprotein-containing complexes and can be used as a carrier to precisely deliver nanoparticles, oligonucleotides and small molecules to cancer cells. AS 1411 reduces PRMT5 expression to inhibit tumor growth in DU145 prostate cancer cells. AS 1411 works by blocking the binding of nucleoproteins to *bcl-2* mRNA in MCF-7 breast cancer cells. AS 1411-coupled Jin nanospheres can inhibit breast cancer cell proliferation in vitro and in mouse models, has the ability to cross the blood-brain barrier with low tissue toxicity ^[2] .

HY-147081A

AS 1411 sodium 2 Publications Verification AGRO-100 sodium		Aptamers
AS 1411 (AGRO-100) sodium is an oligonucleotide aptamer targeting nucleoproteins. AS 1411 sodium inhibits tumor cell proliferation by affecting the activity of nucleoprotein-containing complexes and can be used as a carrier to precisely deliver nanoparticles, oligonucleotides and small molecules to cancer cells. AS 1411 sodium reduces PRMT5 expression to inhibit tumor growth in DU145 prostate cancer cells. S 1411 sodium works by blocking the binding of nucleoproteins to *bcl-2* mRNA in MCF-7 breast cancer cells. S 1411 sodium-coupled Jin nanospheres can inhibit breast cancer cell proliferation in vitro and in mouse models, has the ability to cross the blood-brain barrier with low tissue toxicity ^[2]

HY-118874A

Oblimersen sodium		Antisense Oligonucleotides
Oblimersen sodium is a *BCL-2* inhibitor targeting BCL-2 RNA. Oblimersen sodium specifically binds to the first six codons of the bcl-2 mRNA sequence, resulting in degradation of bcl-2 mRNA and induces apoptosis by down-regulating expression of Bcl-2. Oblimersen sodium can be used for cancer research ^[2] .

HY-153495

Prexigebersen BP1001		Antisense Oligonucleotides
Prexigebersen (BP1001) is an antisense oligonucleotide targeting *Bcl-2* and *Grb2. Prexigebersen exhibits antileukemic activity in cell models. Prexigebersen induces apoptosis (apoptosis), cell cycle arrest and ROS* production in leukemia cells. Prexigebersen inhibits Grb2 expression, thereby suppressing tumor growth and survival. Prexigebersen can be used in studies related to acute myeloid leukemia ^[2].

HY-118874

Oblimersen		Antisense Oligonucleotides
Oblimersen is a *BCL-2* inhibitor targeting BCL-2 RNA. Oblimersen specifically binds to the first six codons of the bcl-2 mRNA sequence, resulting in degradation of bcl-2 mRNA and induces apoptosis by down-regulating expression of Bcl-2. Oblimersen can be used for cancer research ^[2] .

HY-RS01417

BCL2 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
BCL2 Rat Pre-designed siRNA Set A contains three designed siRNAs for BCL2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01415

BCL2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
BCL2 Human Pre-designed siRNA Set A contains three designed siRNAs for BCL2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01416

Bcl2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Bcl2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bcl2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-177618A

Beclanorsen sodium SPC2996 sodium		Antisense Oligonucleotides
Beclanorsen sodium is an antisense oligonucleotide targeted to the mRNA of the Bcl-2 oncoprotein.

HY-177618

Beclanorsen SPC2996		Antisense Oligonucleotides
Beclanorsen is an antisense oligonucleotide targeted to the mRNA of the Bcl-2 oncoprotein.

HY-174777

Human BAK1 mRNA		mRNA
Human BAK1 mRNA encodes the human BCL2 antagonist/killer 1 (BAK1) protein, a member of the BCL2 protein family. BAK1 localizes to mitochondria, and functions to induce apoptosis. It also interacts with the tumor suppressor P53 after exposure to cell stress.

HY-RS01426

Bcl2l10 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Bcl2l10 Rat Pre-designed siRNA Set A contains three designed siRNAs for Bcl2l10 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01418

BCL2A1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
BCL2A1 Human Pre-designed siRNA Set A contains three designed siRNAs for BCL2A1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01421

BCL2L1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
BCL2L1 Human Pre-designed siRNA Set A contains three designed siRNAs for BCL2L1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01430

BCL2L12 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
BCL2L12 Human Pre-designed siRNA Set A contains three designed siRNAs for BCL2L12 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01424

BCL2L10 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
BCL2L10 Human Pre-designed siRNA Set A contains three designed siRNAs for BCL2L10 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS21989

Bcl2l12 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Bcl2l12 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bcl2l12 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01422

Bcl2l1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Bcl2l1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bcl2l1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01432

BCL2L14 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
BCL2L14 Human Pre-designed siRNA Set A contains three designed siRNAs for BCL2L14 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01425

Bcl2l10 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Bcl2l10 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bcl2l10 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01433

BCL2L15 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
BCL2L15 Human Pre-designed siRNA Set A contains three designed siRNAs for BCL2L15 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01431

BCL2L13 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
BCL2L13 Human Pre-designed siRNA Set A contains three designed siRNAs for BCL2L13 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01428

Bcl2l11 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Bcl2l11 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bcl2l11 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01419

Bcl2a1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Bcl2a1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Bcl2a1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01434

BCL2L2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
BCL2L2 Human Pre-designed siRNA Set A contains three designed siRNAs for BCL2L2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01435

Bcl2l2 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Bcl2l2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bcl2l2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01436

Bcl2l2 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Bcl2l2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Bcl2l2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01423

Bcl2l1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Bcl2l1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Bcl2l1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01427

BCL2L11 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
BCL2L11 Human Pre-designed siRNA Set A contains three designed siRNAs for BCL2L11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01429

Bcl2l11 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Bcl2l11 Rat Pre-designed siRNA Set A contains three designed siRNAs for Bcl2l11 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS01420

Bcl2a1a Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Bcl2a1a Mouse Pre-designed siRNA Set A contains three designed siRNAs for Bcl2a1a gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-153494A

Rosomidnar sodium PNT100 sodium		Antisense Oligonucleotides
PNT100 sodium is a 24-base, chemically unmodified DNA oligonucleotide sequence that is complementary to the regulatory region upstream of the BCL-2 gene. Exposure of tumor cells to PNT100 results in suppression of proliferation and cell death.

HY-153494

Rosomidnar PNT100		Antisense Oligonucleotides
PNT100 is a 24-base, chemically unmodified DNA oligonucleotide sequence that is complementary to the regulatory region upstream of the BCL-2 gene. Exposure of tumor cells to PNT100 results in suppression of proliferation and cell death.

HY-174776

Human BAX mRNA		mRNA
Human BAX mRNA encodes the human BCL2 associated X, apoptosis regulator (BAX) protein, a member of the BCL2 protein family. BAX forms a heterodimer with BCL2, and functions as an apoptotic activator. It also plays a role in the mitochondrial apoptotic process.

HY-174635

Human IL15RA mRNA		mRNA Interleukin & Receptors
Human IL15RA mRNA encodes the human interleukin 15 receptor subunit alpha (IL15RA) protein, a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. IL15RA is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2.

HY-RS28507

Bcl2l12 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Bcl2l12 Rat Pre-designed siRNA Set A contains three designed siRNAs for Bcl2l12 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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