FB49
Based on 1 Customer Validation
FB49 is a highly selective inhibitor of Bcl-2-associated athanogene 3 (BAG3), with the Ki of 45 μM. FB49 inhibits the cell growth in human tumoral cells, but has no toxicity in human peripheral mononuclear cells. FB49 block cell cycle in G1 phase and to induce apoptosis as well as autophagy in medulloblastoma HD-MB03 treated cells.
For research use only. We do not sell to patients.
- Purity: 99.76%
- CAS No.: 3074495-82-9
- Formula: C17H18N2O6S
- Molecular Weight:378.40
-
Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Apoptosis Compound Library
HY-L003
-
Anti-Cancer Compound Library
HY-L025
-
Autophagy Compound Library
HY-L029
-
Covalent Screening Library
HY-L036
-
Highly Selective Inhibitors Library
HY-L158
-
Cell Death Library
HY-L162
-
Mitophagy Compound Library
HY-L180
-
Bioactive Compound Library Max
HY-L181
-
Covalent Screening Library Plus
HY-L036P
-
Bioactive Compound Library
HY-L001
-
Anti-Brain Cancer Compound Library
HY-L188
-
Non-Alcoholic Fatty Liver Disease (NAFLD) Compound Library
HY-L199
-
High-Throughput Bioactive Compound Library
HY-L205
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | GI50 |
28 μM
Compound: FB49
|
Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 72 hrs by resazurin dye based analysis
Antiproliferative activity against human A549 cells assessed as cell growth inhibition incubated for 72 hrs by resazurin dye based analysis
|
[PMID: 37783101] |
| PBMC | GI50 |
>100 μM
Compound: FB49
|
Cytotoxicity against PHA stimulated human PBMC cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Cytotoxicity against PHA stimulated human PBMC cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
|
[PMID: 37783101] |
| PBMC | GI50 |
>100 μM
Compound: FB49
|
Cytotoxicity against resting human PBMC cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
Cytotoxicity against resting human PBMC cells assessed as cell growth inhibition incubated for 72 hrs by MTT assay
|
[PMID: 37783101] |
| RS4-11 | GI50 |
6.7 μM
Compound: FB49
|
Antiproliferative activity against human RS4-11 cells assessed as cell growth inhibition incubated for 72 hrs by resazurin dye based analysis
Antiproliferative activity against human RS4-11 cells assessed as cell growth inhibition incubated for 72 hrs by resazurin dye based analysis
|
[PMID: 37783101] |
Chemical Information
-
CAS No. 3074495-82-9
-
Appearance Solid
-
Molecular Weight 378.40
-
Formula C17H18N2O6S
-
Color Light yellow to yellow
-
SMILES
O=C(N(C(C)C(N1CCOCC1)=O)C/2=O)SC2=C/C3=CC=CC(O)=C3O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (264.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
-
Data Sheet (272 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6427 mL | 13.2135 mL | 26.4271 mL | 66.0677 mL |
| 5 mM | 0.5285 mL | 2.6427 mL | 5.2854 mL | 13.2135 mL | |
| 10 mM | 0.2643 mL | 1.3214 mL | 2.6427 mL | 6.6068 mL | |
| 15 mM | 0.1762 mL | 0.8809 mL | 1.7618 mL | 4.4045 mL | |
| 20 mM | 0.1321 mL | 0.6607 mL | 1.3214 mL | 3.3034 mL | |
| 25 mM | 0.1057 mL | 0.5285 mL | 1.0571 mL | 2.6427 mL | |
| 30 mM | 0.0881 mL | 0.4405 mL | 0.8809 mL | 2.2023 mL | |
| 40 mM | 0.0661 mL | 0.3303 mL | 0.6607 mL | 1.6517 mL | |
| 50 mM | 0.0529 mL | 0.2643 mL | 0.5285 mL | 1.3214 mL | |
| 60 mM | 0.0440 mL | 0.2202 mL | 0.4405 mL | 1.1011 mL | |
| 80 mM | 0.0330 mL | 0.1652 mL | 0.3303 mL | 0.8258 mL | |
| 100 mM | 0.0264 mL | 0.1321 mL | 0.2643 mL | 0.6607 mL |
Powered by Bioz