2. Cell Cycle/DNA Damage Apoptosis Epigenetics
  3. HDAC Histone Methyltransferase Caspase Apoptosis DNA/RNA Synthesis
  4. HDAC3-IN-2

HDAC3-IN-2 (compound 4i) is a pyrazinyl hydrazide-based HDAC3 inhibitor (IC50: 14 nM) that efficiently targets triple-negative breast cancer cells. HDAC3-IN-2 is cytotoxic with an IC50 of 0.55 μM against 4T1 and an IC50 of 0.74 μM against MDA-MB-231. HDAC3-IN-2 has anti-tumor efficacy in vivo in tumor-bearing mouse models, selectively increasing the acetylation levels of H3K9, H3K27 and H4K12, increasing the contents of apoptosis-related caspase-3, caspase-7 and cytochrome c, and reducing Proliferation-related Bcl-2, CD44, EGFR, and Ki-67 levels.

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HDAC3-IN-2 Chemical Structure

HDAC3-IN-2 Chemical Structure

CAS No. : 3033039-28-7

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HDAC3-IN-2 Related Antibodies

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Description

HDAC3-IN-2 (compound 4i) is a pyrazinyl hydrazide-based HDAC3 inhibitor (IC50: 14 nM) that efficiently targets triple-negative breast cancer cells. HDAC3-IN-2 is cytotoxic with an IC50 of 0.55 μM against 4T1 and an IC50 of 0.74 μM against MDA-MB-231. HDAC3-IN-2 has anti-tumor efficacy in vivo in tumor-bearing mouse models, selectively increasing the acetylation levels of H3K9, H3K27 and H4K12, increasing the contents of apoptosis-related caspase-3, caspase-7 and cytochrome c, and reducing Proliferation-related Bcl-2, CD44, EGFR, and Ki-67 levels[1].

IC50 & Target

IC50: 14 nM (HDAC3)[1]
Molecular Weight

315.37

Formula

C16H21N5O2
CAS No.
SMILES

COC1=CC=C(CNC2=CN=C(C(NNCCC)=O)C=N2)C=C1
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
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HDAC3-IN-2 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC3-IN-23033039-28-7HDACHistone MethyltransferaseCaspaseApoptosisDNA/RNA SynthesisHistone deacetylasesInhibitorinhibitorinhibit

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