Longan cerebroside II
Longan cerebroside II is a cerebroside found in Typhonium giganteum. Longan cerebroside II shows anti-apoptosis and neuroprotective activity. Longan cerebroside II reduces protein expression of caspase-9, caspase-3, and Bax, increases Bcl-2, cytochrome c levles.
For research use only. We do not sell to patients.
- CAS No.: 220873-86-9
- Formula: C48H91NO9
- Molecular Weight:826.24
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
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Caspase-9 |
Caspase-3 |
Bax |
Bcl-2 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| PC-12 | EC50 |
2.5 μM
Compound: 11
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Neuroprotective activity against 12.5 mM glutamate-induced toxicity in rat PC12 cells assessed as cell viability after 24 hrs by MTT assay
Neuroprotective activity against 12.5 mM glutamate-induced toxicity in rat PC12 cells assessed as cell viability after 24 hrs by MTT assay
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[PMID: 28394604] |
Longan cerebroside II (Compound 11) (0.1-20 μM; 24 h) potently protects PC12 cells from glutamate-induced injury with an EC50 of 2.5 μM, and increases cell viability in a concentration-dependent manner[1].
Longan cerebroside II (0.1-10 μM; 24 h) inhibits glutamate-induced apoptosis in PC12 cells in a concentration-dependent manner[1].
Longan cerebroside II (0.1-10 μM; 24 h) concentration-dependently downregulates caspase-9, caspase-3, and Bax expression, upregulates Bcl-2 expression, and reduces cytosolic cytochrome c levels in PC12 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC12 cells
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Concentration:0.1, 1, 5, 10, 15, 20 μM
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Incubation Time:24 h
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Result:Showed the most potent neuroprotective effect among tested cerebrosides, with an EC50 value of 2.5 μM.
Increased cell survival rate in a concentration-dependent manner.
Significantly elevated cell viability at 0.1 μM compared to the glutamate-only group.
Almost completely prevented glutamate-induced PC12 cell damage at 10 μM.
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Cell Line:PC12 cells
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Concentration:0.1, 1, 10 μM
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Incubation Time:24 h
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Result:Reduced glutamate-induced PC12 cell apoptosis in a concentration-dependent manner.
Reduced apoptosis to 32.42% at 0.1 μM.
Reduced apoptosis to 23.58% at 1 μM.
Reduced apoptosis to 3.13% at 10 μM.
Had no effect on PC12 cell cycle progression.
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Cell Line:PC12 cells
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Concentration:0.1,1, 10 μM
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Incubation Time:24 h
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Result:Reversed glutamate-induced changes in apoptosis-related protein expression in a concentration-dependent manner.
Downregulated the expression of caspase-9, caspase-3, and Bax.
Upregulated Bcl-2 expression.
Decreased cytosolic cytochrome c levels.
Showed the most significant effects at 10 μM.
Chemical Information
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CAS No. 220873-86-9
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Molecular Weight 826.24
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Formula C48H91NO9
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SMILES
O[C@@H](C(N[C@H]([C@H](O)/C=C/CC/C=C\CCCCCCCCC)CO[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CO)=O)CCCCCCCCCCCCCCCCCCCCCC
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Longan cerebroside II Related Classifications
HY-N15466 Related Classifications
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