2. Apoptosis
  3. Apoptosis Caspase Bcl-2 Family
  4. Longan cerebroside II

Longan cerebroside II is a cerebroside found in Typhonium giganteum. Longan cerebroside II shows anti-apoptosis and neuroprotective activity. Longan cerebroside II reduces protein expression of caspase-9, caspase-3, and Bax, increases Bcl-2, cytochrome c levles.

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Longan cerebroside II

Longan cerebroside II Chemical Structure

CAS No. : 220873-86-9

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Longan cerebroside II Related Antibodies

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Description

Longan cerebroside II is a cerebroside found in Typhonium giganteum. Longan cerebroside II shows anti-apoptosis and neuroprotective activity. Longan cerebroside II reduces protein expression of caspase-9, caspase-3, and Bax, increases Bcl-2, cytochrome c levles[1].

IC50 & Target[1]

Caspase-9

 

Caspase-3

 

Bax

 

Bcl-2

 

In Vitro

Longan cerebroside II (Compound 11) (0.1-20 μM; 24 h) potently protects PC12 cells from glutamate-induced injury with an EC50 of 2.5 μM, and increases cell viability in a concentration-dependent manner[1].
Longan cerebroside II (0.1-10 μM; 24 h) inhibits glutamate-induced apoptosis in PC12 cells in a concentration-dependent manner[1].
Longan cerebroside II (0.1-10 μM; 24 h) concentration-dependently downregulates caspase-9, caspase-3, and Bax expression, upregulates Bcl-2 expression, and reduces cytosolic cytochrome c levels in PC12 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Longan cerebroside II Related Antibodies

Cell Viability Assay[1]

Cell Line: PC12 cells
Concentration: 0.1, 1, 5, 10, 15, 20 μM
Incubation Time: 24 h
Result: Showed the most potent neuroprotective effect among tested cerebrosides, with an EC50 value of 2.5 μM.
Increased cell survival rate in a concentration-dependent manner.
Significantly elevated cell viability at 0.1 μM compared to the glutamate-only group.
Almost completely prevented glutamate-induced PC12 cell damage at 10 μM.

Apoptosis Analysis[1]

Cell Line: PC12 cells
Concentration: 0.1, 1, 10 μM
Incubation Time: 24 h
Result: Reduced glutamate-induced PC12 cell apoptosis in a concentration-dependent manner.
Reduced apoptosis to 32.42% at 0.1 μM.
Reduced apoptosis to 23.58% at 1 μM.
Reduced apoptosis to 3.13% at 10 μM.
Had no effect on PC12 cell cycle progression.

Western Blot Analysis[1]

Cell Line: PC12 cells
Concentration: 0.1,1, 10 μM
Incubation Time: 24 h
Result: Reversed glutamate-induced changes in apoptosis-related protein expression in a concentration-dependent manner.
Downregulated the expression of caspase-9, caspase-3, and Bax.
Upregulated Bcl-2 expression.
Decreased cytosolic cytochrome c levels.
Showed the most significant effects at 10 μM.
Molecular Weight

826.24

Formula

C48H91NO9
CAS No.
SMILES

O[C@@H](C(N[C@H]([C@H](O)/C=C/CC/C=C\CCCCCCCCC)CO[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CO)=O)CCCCCCCCCCCCCCCCCCCCCC
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Longan cerebroside II Related Classifications

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Keywords:

Longan cerebroside II220873-86-9ApoptosisCaspaseBcl-2 Familycaspase-9neuroprotective activityPC12 cellsBcl-2Baxglutamateapoptosiscaspase-3cytochrome cstrokeInhibitorinhibitorinhibit

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