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Cat. No.: HY-149622

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Bcl-2-IN-12

Bcl-2-IN-12 (Compound 1) is a Bcl-2 inhibitor (IC₅₀: 6 nM). Bcl-2-IN-12 can be used for cancer research.

For research use only. We do not sell to patients.

CAS No.: 1383737-59-4
Formula: C₄₇H₄₁ClN₄O₆S
Molecular Weight:825.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Bcl-2-IN-12 Chemical Structure

CAS No.: 1383737-59-4

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Sample (0.1mg)

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(In Japan)

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Bcl-2-IN-12 (Compound 1) is a Bcl-2 inhibitor (IC₅₀: 6 nM). Bcl-2-IN-12 can be used for cancer research^[1].

All Bcl-2 Family Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MV4-11	IC₅₀	0.7 μM Compound: 3j	Cytotoxicity against human MV411 cells after 72 hrs by firefly luciferase-based assay in presence of 2% fetal calf serum Cytotoxicity against human MV411 cells after 72 hrs by firefly luciferase-based assay in presence of 2% fetal calf serum	[PMID: 22608393]
SUD4	IC₅₀	2.35 μM Compound: 3j	Cytotoxicity against human SU-DHL4 cells after 72 hrs by firefly luciferase-based assay in presence of 2% fetal calf serum Cytotoxicity against human SU-DHL4 cells after 72 hrs by firefly luciferase-based assay in presence of 2% fetal calf serum	[PMID: 22608393]

Chemical Information

CAS No. 1383737-59-4
Molecular Weight 825.37
Formula C₄₇H₄₁ClN₄O₆S
SMILES

O=C(C1=CC=C(C2=C(CCCC)N(C3=CC=C(C=C3)OC4=CC(Cl)=CC=C4)N=C2CO)C(C(N5CC6=C(CC5)C=CC=C6)=O)=C1)NS(=O)(C7=CC8=C(C=CC=C8)C=C7)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ismail HS, et al. Design, molecular modelling and synthesis of novel benzothiazole derivatives as BCL-2 inhibitors. Sci Rep. 2023 Sep 20;13(1):15554. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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