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Cat. No.: HY-149622

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Bcl-2-IN-12

Bcl-2-IN-12 (Compound 1) is a Bcl-2 inhibitor (IC₅₀: 6 nM). Bcl-2-IN-12 can be used for cancer research.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 1383737-59-4
Formule: C₄₇H₄₁ClN₄O₆S
Masse moléculaire:825.37

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Bcl-2-IN-12 Chemical Structure

CAS No.: 1383737-59-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

Bcl-2-IN-12 (Compound 1) is a Bcl-2 inhibitor (IC₅₀: 6 nM). Bcl-2-IN-12 can be used for cancer research^[1].

Voir tous les produits spécifiques à Isoform Bcl-2 Family :

Cellular Effect

Cell Line	Type	Value	Description	References
MV4-11	IC₅₀	0.7 μM Compound: 3j	Cytotoxicity against human MV411 cells after 72 hrs by firefly luciferase-based assay in presence of 2% fetal calf serum Cytotoxicity against human MV411 cells after 72 hrs by firefly luciferase-based assay in presence of 2% fetal calf serum	[PMID: 22608393]
SUD4	IC₅₀	2.35 μM Compound: 3j	Cytotoxicity against human SU-DHL4 cells after 72 hrs by firefly luciferase-based assay in presence of 2% fetal calf serum Cytotoxicity against human SU-DHL4 cells after 72 hrs by firefly luciferase-based assay in presence of 2% fetal calf serum	[PMID: 22608393]

Chemical Information

CAS No. 1383737-59-4
Masse moléculaire 825.37
Formule C₄₇H₄₁ClN₄O₆S
SMILES

O=C(C1=CC=C(C2=C(CCCC)N(C3=CC=C(C=C3)OC4=CC(Cl)=CC=C4)N=C2CO)C(C(N5CC6=C(CC5)C=CC=C6)=O)=C1)NS(=O)(C7=CC8=C(C=CC=C8)C=C7)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Ismail HS, et al. Design, molecular modelling and synthesis of novel benzothiazole derivatives as BCL-2 inhibitors. Sci Rep. 2023 Sep 20;13(1):15554. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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