Gymnoside II 

Gymnoside II is one of the main bioactive constituents isolated from Bletilla striata. Gymnoside II inhibits nano SiO₂-induced A549 cell viability reduction, apoptosis, and ROS generation by activating Nrf2. Gymnoside II upregulates HO-1 and γ-GCSc, while downregulating the Bax/Bcl-2 ratio. Gymnoside II is applicable for research on nano SiO₂-induced pulmonary injury^[1].

Gymnoside II (1–50 µM; 24 h) alleviated the reduction in A549 cell viability induced by nano-level SiO₂ and did not affect the proliferation of normal cells ^[1].
Gymnoside II (25 μM; pre-treatment for 2 h + co-culture for 24 h) inhibits nm SiO₂-induced apoptosis in A549 cells by normalizing the expression of apoptotic proteins and reducing the percentage of apoptotic cells ^[1].
Gymnoside II (25 µM; pretreatment for 2 h followed by co-culture for 24 h) reduces nm SiO₂-induced ROS generation in A549 cells^[1].
Gymnoside II (25 µM; pretreatment for 2 h followed by coculture for 24 h) upregulates the expression of Nrf2, HO-1, and γ-GCS_c and activates the Nrf2 signaling pathway in A549 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

458.46

C₂₁H₃₀O₁₁

899430-02-5

OC[C@H]([C@H]([C@@H]([C@H]1O)O)O)O[C@H]1OC2=CC=C(C=C2)COC(C[C@](C(O)=O)(O)CC(C)C)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Chen G, et al. n-BuOH extract of Bletilla striata exerts chemopreventive effects on lung against SiO₂ nanoparticles through activation of Nrf2 pathway. Phytomedicine. 2021;82:153445.  [Content Brief]