Gymnoside II
Gymnoside II is one of the main bioactive constituents isolated from Bletilla striata. Gymnoside II inhibits nano SiO2-induced A549 cell viability reduction, apoptosis, and ROS generation by activating Nrf2. Gymnoside II upregulates HO-1 and γ-GCSc, while downregulating the Bax/Bcl-2 ratio. Gymnoside II is applicable for research on nano SiO2-induced pulmonary injury.
For research use only. We do not sell to patients.
- CAS No.: 899430-02-5
- Formula: C21H30O11
- Molecular Weight:458.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HO-1 |
Bcl-xL |
Bcl-2 |
Gymnoside II (1–50 µM; 24 h) alleviated the reduction in A549 cell viability induced by nano-level SiO2 and did not affect the proliferation of normal cells [1].
Gymnoside II (25 μM; pre-treatment for 2 h + co-culture for 24 h) inhibits nm SiO2-induced apoptosis in A549 cells by normalizing the expression of apoptotic proteins and reducing the percentage of apoptotic cells [1].
Gymnoside II (25 µM; pretreatment for 2 h followed by co-culture for 24 h) reduces nm SiO2-induced ROS generation in A549 cells[1].
Gymnoside II (25 µM; pretreatment for 2 h followed by coculture for 24 h) upregulates the expression of Nrf2, HO-1, and γ-GCSc and activates the Nrf2 signaling pathway in A549 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 cells
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Concentration:1, 10, 25, 50 μM (with or without nm SiO₂)
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Incubation Time:24 h
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Result:Elevated the decreased cell viability induced by nm SiO₂ to a relative normal level.
Did not affect normal A549 cell proliferation.
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Cell Line:A549 cells
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Concentration:25 μM (pretreated for 2 h, then co-cultured with nm SiO₂)
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Incubation Time:24 h (co-culture with nm SiO₂)
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Result:Reduced the apoptotic rate from 28.5% to 8.72% and reversed aberrant expression of pro-apoptotic (Bax, Cleaved-caspase 3) and anti-apoptotic (Bcl-2) proteins.
Chemical Information
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CAS No. 899430-02-5
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Molecular Weight 458.46
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Formula C21H30O11
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SMILES
OC[C@H]([C@H]([C@@H]([C@H]1O)O)O)O[C@H]1OC2=CC=C(C=C2)COC(C[C@](C(O)=O)(O)CC(C)C)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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