2. Apoptosis
  3. Apoptosis Caspase Bcl-2 Family
  4. Apoptotic agent-2

Apoptotic agent-2 (compound 14b) induces apoptosis by down-regulation of Bcl-2 and up-regulation of Bax and caspase-3. Apoptotic agent-2 exhibits anti-proliferative activities and can be used for cancer research.

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Apoptotic agent-2 Chemical Structure

Apoptotic agent-2 Chemical Structure

CAS No. : 2482310-18-7

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Apoptotic agent-2 Related Antibodies

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

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Description

Apoptotic agent-2 (compound 14b) induces apoptosis by down-regulation of Bcl-2 and up-regulation of Bax and caspase-3. Apoptotic agent-2 exhibits anti-proliferative activities and can be used for cancer research[1].

IC50 & Target[1]

Bax

 

Caspase 3

 

Bcl-2

 

In Vitro

Apoptotic agent-2 (compound 14b) (24 hours) has selective anti-proliferative activities against HCT-116, HepG-2, MCF-7 and WI-38 (normal human cells) cells with IC50 values of 1.96, 1.12, 2.38 and 107.5 µM, respectively[1].
Apoptotic agent-2 (compound 14b) (1.12 μM; 24 hours; HepG-2 cells) induces cell apoptosis, which increases the levels of active Caspase-3 and BAX by 10.92 folds and 9.7 folds, respectively, and decreases the level of Bcl-2 by 3.3 folds[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptotic agent-2 Related Antibodies

Cell Cycle Analysis[1]

Cell Line: HepG-2 cells
Concentration: 1.12 μM
Incubation Time: 24 hours
Result: The percentage of cells in the G2-M phase increased while the percentage of cells in G0-G1 phase and S phase decreased.

Apoptosis Analysis[1]

Cell Line: HepG-2 cells
Concentration: 1.12 μM
Incubation Time: 24 hours
Result: Increased the early apoptosis ratio from 0.69% to 5.17% and increased the late apoptosis ratio from 0.32% to 12.11%.
Molecular Weight

481.96

Formula

C25H16ClN7S
CAS No.
SMILES

CC1=C(/N=N/C2=CC=C(Cl)C=C2)SC(N/N=C3C4=C(C5=NC6=CC=CC=C6N=C5\3)C=CC=C4)=N1
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Apoptotic agent-2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apoptotic agent-22482310-18-7Apoptotic agent2Apoptotic agent 2ApoptosisCaspaseBcl-2 Familyapoptosisanticancercaspase-3Bcl-2BaxInhibitorinhibitorinhibit

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