AS 1411 sodium
Based on 3 publication(s) in Google Scholar
AS 1411 (AGRO-100) sodium is an oligonucleotide aptamer targeting nucleoproteins. AS 1411 sodium inhibits tumor cell proliferation by affecting the activity of nucleoprotein-containing complexes and can be used as a carrier to precisely deliver nanoparticles, oligonucleotides and small molecules to cancer cells. AS 1411 sodium reduces PRMT5 expression to inhibit tumor growth in DU145 prostate cancer cells. S 1411 sodium works by blocking the binding of nucleoproteins to bcl-2 mRNA in MCF-7 breast cancer cells. S 1411 sodium-coupled Jin nanospheres can inhibit breast cancer cell proliferation in vitro and in mouse models, has the ability to cross the blood-brain barrier with low tissue toxicity
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- Pureté : 91.58%
- Masse moléculaire:8272.31
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Stockage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) AS 1411 sodium
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Activité biologique
Description
IC50 & Target
[2]|
Bcl-2 |
In Vitro
AS 1411 (10 μM, 0-48 h) sodium alters the nuclear localization of PRMT5 in DU145 cells[1].
AS 1411 (10 μM, 24 h) sodium reduces PRMT5 expression and increases the expression of cyclin E2 and ST7[1].
AS 1411 (0-20 μM, 0-96 h) sodium inhibits MCF-7 cell proliferation without affecting MCF-10A cells[2].
AS 1411 (2 μM, 1 h) sodium distributes in the nuclei of both MCF-7 and MCF-10A cells, but its cytoplasmic distribution is higher in MCF-7 cells[2].
AS 1411 (10 μM, 72 h) sodium inhibits the stability of Bcl-2 mRNA in MCF-7 and MDA-MB-231 cells, with no effect on MCF-10A cells[2].
AS 1411 (0-10 μM, 72 h) sodium inhibits the binding of nucleoproteins to bcl-2 mRNA in MCF-7 cells[2].
AS 1411 sodium conjugated with gold nanoparticles (0-800 nM, 72 h) exerts a stronger antiproliferative effect on MCF-7 and MDA-MB-231 cells compared to AS 1411 alone, without affecting MCF-10A cells[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MCF-7; MDA-MB-231; MCF-10A
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Concentration:0, 200, 400, 600, 800 nM
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Incubation Time:72 h
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Result:Inhibited MCF-7 cell survival by more than 80% at 200 nM, whereas neither AS1411 alone nor control GNS had a significant effect under these conditions. AS1411GNS (88% cell death at 200 nM) was significantly increased in MDA-MB-231 cells compared to AS1411 (27% cell death at 10 μM).
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Cell Line:MCF-7, MCF-10A
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Concentration:10 μM
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Incubation Time:72 h
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Result:Reduced the stability of bcl-2 mRNA, reducing the half-life of bcl-2 from 10h to 1h in MCF-7 cells and from 11h to 1.2h in MDA-MB-231 cells, but had no effect on MCF-10A cells.
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Cell Line:DU145; DU145 cells transfected with siRNA; NM23
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Concentration:10 μM
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Incubation Time:0, 1, 4, 24, 48 h
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Result:Reduced nucleolar protein-associated PRMT5 in the nucleus of DU145 cells and increased nucleolar protein-associated PRMT5 in the cytoplasm, which was related to time and dose.
Reduced the expression of PRMT5 in DU145 cells, upregulated the expression of PRMT5 cyclin2 and ST7 and inhibited tumor proliferation.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female nude mice bearing MDA-MB-231 xenografts[3]
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Dosage:22 μg; once a day; 12 days
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Administration:Intravenous injection (i.v.)
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Result:Took up and retained in tumors and cleared in normal tissues.
Chemical Information
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Appearance Solid
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Masse moléculaire 8272.31
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Color White to off-white
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SMILES
[AS 1411 (sodium)]
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Synonyms
AGRO-100 sodium
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (3)
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Journal Impact Factor
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Most Recent
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Phytomedicine
2025 Aug:144:156932. PMID: 40482618 -
Int J Pharm X
An aptamer-conjugated mesoporous polydopamine formulation for synergistic targeted and photothermal therapy of hepatocellular carcinoma. [Abstract]2025 Apr 24:9:100335. PMID: 40927752 -
Pureté et documentation
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Fiche technique (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (1518 KB)
Références
[1]. Teng Y, et al. AS1411 alters the localization of a complex containing protein arginine methyltransferase 5 and nucleolin. Cancer Res. 2007;67(21):10491-10500. [Content Brief]
[2]. Soundararajan S, et al. The nucleolin targeting aptamer AS1411 destabilizes Bcl-2 messenger RNA in human breast cancer cells. Cancer Res. 2008;68(7):2358-2365. [Content Brief]
[3]. Mohammad T Malik, et al. AS1411-conjugated gold nanospheres and their potential for breast cancer therapy. Oncotarget. 2015 Sep 8;6(26):22270-81. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AS 1411 sodium Related Classifications
HY-147081A Related Classifications
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