2. Epigenetics Apoptosis
  3. Histone Methyltransferase Bcl-2 Family
  4. AS 1411 sodium

AS 1411 sodium  (Synonyms: AGRO-100 sodium)

Cat. No.: HY-147081A Purity: 91.58%
COA
SDS
Handling Instructions Technical Support

AS 1411 (AGRO-100) sodium is an oligonucleotide aptamer targeting nucleoproteins. AS 1411 sodium inhibits tumor cell proliferation by affecting the activity of nucleoprotein-containing complexes and can be used as a carrier to precisely deliver nanoparticles, oligonucleotides and small molecules to cancer cells. AS 1411 sodium reduces PRMT5 expression to inhibit tumor growth in DU145 prostate cancer cells. S 1411 sodium works by blocking the binding of nucleoproteins to bcl-2 mRNA in MCF-7 breast cancer cells. S 1411 sodium-coupled Jin nanospheres can inhibit breast cancer cell proliferation in vitro and in mouse models, has the ability to cross the blood-brain barrier with low tissue toxicity

For research use only. We do not sell to patients.

DNA, d(G-G-T-G-G-T-G-G-T-G-G-T-T-G-T-G-G-T-G-G-T-G-G-T-G-G), sodium salt

AS 1411 sodium Chemical Structure

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Based on 2 publication(s) in Google Scholar

Other Forms of AS 1411 sodium:

AS 1411 sodium Related Antibodies

Top Publications Citing Use of Products

View All Histone Methyltransferase Isoform Specific Products:

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EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 NSD3/WHSC1L1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

View All Bcl-2 Family Isoform Specific Products:

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3 Bad

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Description

AS 1411 (AGRO-100) sodium is an oligonucleotide aptamer targeting nucleoproteins. AS 1411 sodium inhibits tumor cell proliferation by affecting the activity of nucleoprotein-containing complexes and can be used as a carrier to precisely deliver nanoparticles, oligonucleotides and small molecules to cancer cells. AS 1411 sodium reduces PRMT5 expression to inhibit tumor growth in DU145 prostate cancer cells. S 1411 sodium works by blocking the binding of nucleoproteins to bcl-2 mRNA in MCF-7 breast cancer cells. S 1411 sodium-coupled Jin nanospheres can inhibit breast cancer cell proliferation in vitro and in mouse models, has the ability to cross the blood-brain barrier with low tissue toxicity[1][2][3]

IC50 & Target[2]

Bcl-2

 

In Vitro

AS 1411 (10 μM, 0-48 h) sodium alters the nuclear localization of PRMT5 in DU145 cells[1].
AS 1411 (10 μM, 24 h) sodium reduces PRMT5 expression and increases the expression of cyclin E2 and ST7[1].
AS 1411 (0-20 μM, 0-96 h) sodium inhibits MCF-7 cell proliferation without affecting MCF-10A cells[2].
AS 1411 (2 μM, 1 h) sodium distributes in the nuclei of both MCF-7 and MCF-10A cells, but its cytoplasmic distribution is higher in MCF-7 cells[2].
AS 1411 (10 μM, 72 h) sodium inhibits the stability of Bcl-2 mRNA in MCF-7 and MDA-MB-231 cells, with no effect on MCF-10A cells[2].
AS 1411 (0-10 μM, 72 h) sodium inhibits the binding of nucleoproteins to bcl-2 mRNA in MCF-7 cells[2].
AS 1411 sodium conjugated with gold nanoparticles (0-800 nM, 72 h) exerts a stronger antiproliferative effect on MCF-7 and MDA-MB-231 cells compared to AS 1411 alone, without affecting MCF-10A cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AS 1411 sodium Related Antibodies

Cell Proliferation Assay[3]

Cell Line: MCF-7; MDA-MB-231; MCF-10A
Concentration: 0, 200, 400, 600, 800 nM
Incubation Time: 72 h
Result: Inhibited MCF-7 cell survival by more than 80% at 200 nM, whereas neither AS1411 alone nor control GNS had a significant effect under these conditions. AS1411GNS (88% cell death at 200 nM) was significantly increased in MDA-MB-231 cells compared to AS1411 (27% cell death at 10 μM).

RT-PCR[2]

Cell Line: MCF-7, MCF-10A
Concentration: 10 μM
Incubation Time: 72 h
Result: Reduced the stability of bcl-2 mRNA, reducing the half-life of bcl-2 from 10h to 1h in MCF-7 cells and from 11h to 1.2h in MDA-MB-231 cells, but had no effect on MCF-10A cells.

Western Blot Analysis[1]

Cell Line: DU145; DU145 cells transfected with siRNA; NM23
Concentration: 10 μM
Incubation Time: 0, 1, 4, 24, 48 h
Result: Reduced nucleolar protein-associated PRMT5 in the nucleus of DU145 cells and increased nucleolar protein-associated PRMT5 in the cytoplasm, which was related to time and dose.
Reduced the expression of PRMT5 in DU145 cells, upregulated the expression of PRMT5 cyclin2 and ST7 and inhibited tumor proliferation.
In Vivo

AS 1411 sodium coupled with gold nanospheres (GNS) shows antitumor activity in a mouse model of breast cancer cell xenografts[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female nude mice bearing MDA-MB-231 xenografts[3]
Dosage: 22 μg; once a day; 12 days
Administration: Intravenous injection (i.v.)
Result: Took up and retained in tumors and cleared in normal tissues.
Molecular Weight

8272.31

Appearance

Solid

Color

White to off-white

SMILES

[AS 1411 (sodium)]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: 99.52%

SDS (252 KB)

COA (243 KB) RP-HPLC (236 KB) MS (86 KB)

Handling Instructions (1518 KB)
References
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AS 1411 sodium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AS 1411AGRO-100AS1411AS-1411AGRO100AGRO 100Histone MethyltransferaseBcl-2 FamilyInhibitorinhibitorinhibit

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