2. Apoptosis Cell Cycle/DNA Damage GPCR/G Protein
  3. Bcl-2 Family DNA/RNA Synthesis Apoptosis Prostaglandin Receptor
  4. Proquinazid

Proquinazid is a Bcl-2 and PCNA modulator, oxidative stress inducer, genotoxin and apoptosis inducer. Proquinazid causes DNA damage and also triggers apoptosis by regulating pro-apoptotic and anti-apoptotic proteins.

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Proquinazid

Proquinazid Chemical Structure

CAS No. : 189278-12-4

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Other Forms of Proquinazid:

Proquinazid Related Antibodies

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RNASE L DNA Polymerases RNA Polymerases Helicases DNA Ligase

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DP EP FP IP TXA2/TP TXB2

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Description

Proquinazid is a Bcl-2 and PCNA modulator, oxidative stress inducer, genotoxin and apoptosis inducer. Proquinazid causes DNA damage and also triggers apoptosis by regulating pro-apoptotic and anti-apoptotic proteins[1].

In Vivo

Proquinazid (1-8 mg/kg bw/day; p.o.; daily; 28 days) induces dose-dependent hepatotoxicity and nephrotoxicity in male Wistar rats via oxidative stress, genotoxic damage, and apoptotic cell death, with significant effects observed even at the 1 mg/kg bw/day dose[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wistar (male, 8 weeks old, 170 ± 21 g)[1]
Dosage: 1 mg/kg bw/day; 2 mg/kg bw/day; 4 mg/kg bw/day; 8 mg/kg bw/day
Administration: p.o.; daily; 28 days
Result: Increased body weight gain significantly.
Increased serum creatinine to 104.06 μmol/L (8 mg/kg).
Increased uric acid to 97.16 μmol/L (8 mg/kg).
Increased urea to 16.86 mmol/L (8 mg/kg).
Increased AST to136 UI/L (8 mg/kg).
Increased ALT 47.66 UI/L (8 mg/kg).
Increased ALP to 203.66 UI/L (8 mg/kg).
Increased LDH to 579 UI/L (8 mg/kg).
Increased SOD, CAT, GST activities at 1 mg/kg and 2 mg/kg, then decreased at 4 mg/kg and 8 mg/kg in liver and kidney.
Increased GPx activity in a dose-dependent manner across all doses in liver and kidney.
Increased renal MDA to 32.92 μmol/mg protein (8 mg/kg).
Increased hepatic MDA to 62.69 μmol/mg protein (8 mg/kg).
Increased renal protein carbonyl to 208.13 nmol/mg protein (8 mg/kg).
Increased hepatic protein carbonyl to 295.61 nmol/mg protein (8 mg/kg).
Increased TUNEL-positive apoptotic cells in a dose-dependent manner in liver and kidney.
Induced dose-dependent downregulation of Bcl-2 and PCNA, and upregulation of Bax, p53, and caspase-3, with increased Bax/Bcl-2 ratio in liver and kidney.
Molecular Weight

372.21

Formula

C14H17IN2O2
CAS No.
SMILES

O=C1C=2C=C(I)C=CC2N=C(OCCC)N1CCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Proquinazid Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Proquinazid189278-12-4Bcl-2 FamilyDNA/RNA SynthesisApoptosisProstaglandin ReceptorBaxBcl-2malondialdehydep53PCNAcatalaseglutathione S-transferasesuperoxide dismutasecaspase-3male Wistar ratsInhibitorinhibitorinhibit

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