1. Apoptosis
  2. Bcl-2 Family
  3. MCL-1/BCL-2-IN-1

MCL-1/BCL-2-IN-1 

Cat. No.: HY-129681 Purity: 98.04%
Handling Instructions

MCL-1/BCL-2-IN-2 (Compound Nap-1) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor with IC50s of 4.45 and 3.18 μM, respectively.

For research use only. We do not sell to patients.

MCL-1/BCL-2-IN-1 Chemical Structure

MCL-1/BCL-2-IN-1 Chemical Structure

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 517 In-stock
Estimated Time of Arrival: December 31
5 mg USD 400 In-stock
Estimated Time of Arrival: December 31
10 mg USD 680 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1050 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1750 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2300 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

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Description

MCL-1/BCL-2-IN-2 (Compound Nap-1) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor with IC50s of 4.45 and 3.18 μM, respectively[1].

IC50 & Target[1]

Mcl-1

4.45 μM (IC50)

Bcl-2

3.18 μM (IC50)

Molecular Weight

587.53

Formula

C₃₁H₂₇BrN₂O₃S

SMILES

O=C(N(CCNC(C1=CC=C(C(C)(C)C)C=C1)=O)C2=O)C3=CC=C(SC4=CC=C(Br)C=C4)C5=C3C2=CC=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (17.02 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7020 mL 8.5102 mL 17.0204 mL
5 mM 0.3404 mL 1.7020 mL 3.4041 mL
10 mM 0.1702 mL 0.8510 mL 1.7020 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

MCL-1/BCL-2-IN-1Bcl-2 FamilyInhibitorinhibitorinhibit

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Product Name:
MCL-1/BCL-2-IN-1
Cat. No.:
HY-129681
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