2. Apoptosis
  3. Bcl-2 Family
  4. MCL-1/BCL-2-IN-1

MCL-1/BCL-2-IN-2 (Compound Nap-1) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor with IC50s of 4.45 and 3.18 μM, respectively.

For research use only. We do not sell to patients.

MCL-1/BCL-2-IN-1 Chemical Structure

MCL-1/BCL-2-IN-1 Chemical Structure

CAS No. : 2493256-46-3

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

MCL-1/BCL-2-IN-1 Related Antibodies

Top Publications Citing Use of Products

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

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Description

MCL-1/BCL-2-IN-2 (Compound Nap-1) is a potent and selective Mcl-1 and Bcl-2 dual inhibitor with IC50s of 4.45 and 3.18 μM, respectively[1].

IC50 & Target[1]

Mcl-1

4.45 μM (IC50)

Bcl-2

3.18 μM (IC50)

Molecular Weight

587.53

Formula

C31H27BrN2O3S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N(CCNC(C1=CC=C(C(C)(C)C)C=C1)=O)C2=O)C3=CC=C(SC4=CC=C(Br)C=C4)C5=C3C2=CC=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (17.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7020 mL 8.5102 mL 17.0204 mL
5 mM 0.3404 mL 1.7020 mL 3.4041 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7020 mL 8.5102 mL 17.0204 mL 42.5510 mL
5 mM 0.3404 mL 1.7020 mL 3.4041 mL 8.5102 mL
10 mM 0.1702 mL 0.8510 mL 1.7020 mL 4.2551 mL
15 mM 0.1135 mL 0.5673 mL 1.1347 mL 2.8367 mL
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MCL-1/BCL-2-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MCL-1/BCL-2-IN-12493256-46-3Bcl-2 FamilyInhibitorinhibitorinhibit

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