Bcl-2-IN-24
Bcl-2-IN-24 (Compound 11g) is an efficient and selective Bcl-2 inhibitor with a Kd value of 11.3 μM. Bcl-2-IN-24 exhibits anti-proliferative activity against HCT-116 cells and A549 cells. Bcl-2-IN-24 effectively inhibits the colony-forming ability of tumor cells and induces cell apoptosis. Bcl-2-IN-24 can be used for research on colon cancer and lung cancer.
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- CAS No.: 3051861-49-2
- Formule: C17H11ClFN3O
- Masse moléculaire:327.74
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
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Activité biologique
Description
Chemical Information
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CAS No. 3051861-49-2
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Masse moléculaire 327.74
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Formule C17H11ClFN3O
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SMILES
O=C(C1=CC=C(C=C1)N2C=NC=N2)/C=C/C3=C(C=CC(F)=C3)Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Quan YS, et al. Discovery of chalcone-1,2,4-triazole derivatives with potent anti-tumor activity targeting Bcl-2: In vitro and in vivo evaluation. Bioorg Chem. 2025 Dec 20;169:109371. doi: 10.1016/j.bioorg.2025.109371. Epub ahead of print. Erratum in: Bioorg Chem. 2026 Jan 12:109480. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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