EGFR/BRAFV600E-IN-6
EGFR/BRAFV600E-IN-6 (Compound 7c) is a dual EGFR/BRAFV600E inhibitor with IC50 values of 0.12 and 0.05 μM. EGFR/BRAFV600E-IN-6 can activate caspase-3/8/9, unregulate Bax expression and downregulate Bcl-2 levels. EGFR/BRAFV600E-IN-6 can induce apoptosis and shows antioxidant activity. EGFR/BRAFV600E-IN-6 can be used for the research of cancer, such as colon cancer.
For research use only. We do not sell to patients.
- CAS No.: 3120155-78-1
- Formula: C28H21N5O3S
- Molecular Weight:507.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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BRafV600E 0.05 mM (IC50) |
Caspase 3 |
Caspase-8 |
Caspase-9 |
Bax |
Bcl-2 |
EGFR/BRAFV600E-IN-6 shows anti-proliferation activity against HT-29, MCF-7, A549 and Panc-1 cells with IC50 values of 8, 4, 6 and 7 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3120155-78-1
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Molecular Weight 507.56
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Formula C28H21N5O3S
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SMILES
COC(C=C1)=CC=C1C2=C(C#N)C(NC(C(C=C3)=CC=C3NC(CSC4=NC5=CC=CC=C5N4)=O)=C2)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR/BRAFV600E-IN-6 Related Classifications
HY-180154 Related Classifications
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