2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK MAPK/ERK Pathway Apoptosis
  3. EGFR Raf Caspase Bcl-2 Family Apoptosis
  4. EGFR/BRAFV600E-IN-6

EGFR/BRAFV600E-IN-6 (Compound 7c) is a dual EGFR/BRAFV600E inhibitor with IC50 values of 0.12 and 0.05 μM. EGFR/BRAFV600E-IN-6 can activate caspase-3/8/9, unregulate Bax expression and downregulate Bcl-2 levels. EGFR/BRAFV600E-IN-6 can induce apoptosis and shows antioxidant activity. EGFR/BRAFV600E-IN-6 can be used for the research of cancer, such as colon cancer.

For research use only. We do not sell to patients.

EGFR/BRAFV600E-IN-6

EGFR/BRAFV600E-IN-6 Chemical Structure

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EGFR/BRAFV600E-IN-6 Related Antibodies

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3 Bad

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Description

EGFR/BRAFV600E-IN-6 (Compound 7c) is a dual EGFR/BRAFV600E inhibitor with IC50 values of 0.12 and 0.05 μM. EGFR/BRAFV600E-IN-6 can activate caspase-3/8/9, unregulate Bax expression and downregulate Bcl-2 levels. EGFR/BRAFV600E-IN-6 can induce apoptosis and shows antioxidant activity. EGFR/BRAFV600E-IN-6 can be used for the research of cancer, such as colon cancer[1].

IC50 & Target[1]

BRafV600E

0.05 mM (IC50)

Caspase 3

 

Caspase-8

 

Caspase-9

 

Bax

 

Bcl-2

 

In Vitro

EGFR/BRAFV600E-IN-6 shows anti-proliferation activity against HT-29, MCF-7, A549 and Panc-1 cells with IC50 values of 8, 4, 6 and 7 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

EGFR/BRAFV600E-IN-6 Related Antibodies
Molecular Weight

507.56

Formula

C28H21N5O3S
SMILES

COC(C=C1)=CC=C1C2=C(C#N)C(NC(C(C=C3)=CC=C3NC(CSC4=NC5=CC=CC=C5N4)=O)=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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EGFR/BRAFV600E-IN-6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EGFR/BRAFV600E-IN-6EGFRRafCaspaseBcl-2 FamilyApoptosisEpidermal growth factor receptorErbB-1HER1Raf kinasesInhibitorinhibitorinhibit

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