(S)-(-)-Perillic acid 

(S)-(-)-Perillic acid is a terpenoid plant extract with antimicrobial and anticancer activities. (S)-(-)-Perillic acid induces cell apoptosis and cell cycle arrest, and increases the levell of Bax, Bcl2, p21 and caspase-3 proteins. (S)-(-)-Perillic acid can be used for cancer and infection research^[1][2][3].

(S)-(-)-Perillic acid (1.0-3.5 mM; 24, 48 and 72 hours) time- and dose-dependently inhibits the growth of arterial smooth muscle cells (SMCs)^[1].
(S)-(-)-Perillic acid (1.0-3.5 mM; 20 hours) dose-dependently inhibits the nuclear incorporation of thymidine by rat SMC^[1].
(S)-(-)-Perillic acid (2.5 mM; 24 hours) blocks cell cycle progression in G0/G1 interphase and induces apoptosis of SMCs^[1].
(S)-(-)-Perillic acid (1.0-3.5 mM; 20 hours) dose-dependently inhibits [³H]FOH and [³H]GGOH incorporation into specific low molecular weight proteins^[1].
(S)-(-)-Perillic acid (0.5 mM; 24 h) increases Bax, Bcl2, p21, and caspase-3 proteins in H520 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

166.22

C₁₀H₁₄O₂

23635-14-5

O=C(C1=CC[C@@H](C(C)=C)CC1)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Ferri N, et al. Effect of S(-) perillic acid on protein prenylation and arterial smooth muscle cell proliferation. Biochem Pharmacol. 2001 Dec 15;62(12):1637-45.  [Content Brief]

  [2]. Yeruva L, et al. Perillyl alcohol and perillic acid induced cell cycle arrest and apoptosis in non small cell lung cancer cells. Cancer Lett. 2007 Nov 18;257(2):216-26.  [Content Brief]

  [3]. Khandelia H, et al. Interaction of salicylate and a terpenoid plant extract with model membranes: reconciling experiments and simulations. Biophys J. 2010 Dec 15;99(12):3887-94.  [Content Brief]