Bak Antibody (YA6045)

Cat. No.: HY-P86353: Data Sheet User Guide for Antibodies
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Bak Antibody (YA6045) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bak.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

사이즈		재고
50 μL		견적 받기
100 μL		견적 받기

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
제품 설명

제품 설명

Bak Antibody (YA6045) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Bak.

Host

Rabbit

Clonality

Monoclonal

분자량

Predicted band size: 23 kDa;

Observed band size: 23 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q16611

Gene ID

578 [NCBI]

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:200-1:1000
WB WB: Western Blot	1:2000-1:10000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:200-1:1000
ELISA ELISA: Enzyme Linked Immunosorbent Assay	1:5000-1:20000
IP IP: Immunoprecipitation	1:50-1:200

Purity	Protein A	Conjugation	Non-conjugated
Modification	Unmodified	Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

선적

Shipping with blue ice.

Background

Function：Plays a role in the mitochondrial apoptotic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases

Subcellular Localization：Mitochondrion outer membrane; Single-pass membrane protein

Expression：
Tissue_specificity:This gene is expressed in a variety of tissues, with the highest expression levels in the heart and skeletal muscle.

Isoforms & Post-Translational Modification：Q16611 has 2 isomers: Q16611-1: 23409 Da (predicted); Q16611-2: 16872 Da (predicted).

Subunit：Homodimer. Formation of the homodimer is zinc-dependent (PubMed:17157251). Forms heterodimers with BCL2 and BCL2L1 isoform Bcl-X(L) (PubMed:9020082). Forms heterooligomers with BAX (PubMed:29531808). Interacts with BCL2A1 (By similarity). Interacts with RTL10/BOP (PubMed:23055042). Interacts with VDAC1 (PubMed:25296756). Interacts with GIMAP3/IAN4 and GIMAP5/IAN5 (PubMed:16509771)

Synonyms

BAK1; BAK; BCL2L7; CDN1; Bcl-2 homologous antagonist/killer; Apoptosis regulator BAK; Bcl-2-like protein 7; Bcl2-L-7

각종 서류

User Guide for Antibodies (1077 KB)