Mito-fisetin mF7
Mito-fisetin mF7 is a lipophilic derivative of Fisetin (HY-N0182). Mito-fisetin mF7 interacts with AKT and Bcl-2, limiting their stability and functionality. Mito-fisetin mF7 stimulates impairs mitochondrial function and reduces metabolic activity of cancer cells. Mito-fisetin mF7 can be used for the research of ER-positive breast cancer.
For research use only. We do not sell to patients.
- CAS No.: 3106880-06-9
- Formula: C52H42IO7P
- Molecular Weight:936.76
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Bcl-2 |
Mito-fisetin mF7 (1-10 μM; 24 h) reduces metabolic activity of ER-positive HCC1500, CAMA-1, HCC1428, and ZR-75-30 breast cancer cells, while normal BJ fibroblasts and MCF10F cells are less sensitive[1].
Mito-fisetin mF7 (5 μM; 6 h) disrupts mitochondrial function in proliferating HCC1428 breast cancer cells[1].
Mito-fisetin mF7 (0.01-5 μM; overnight at 37 °C) directly interacts with recombinant human AKT and Bcl-2 proteins, reducing detectable protein levels as measured by dot-blot densitometry[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:normal BJ fibroblasts, noncancerous mammary epithelial MCF10F cells, ER-positive breast cancer cell lines (HCC1500, CAMA-1, HCC1428, ZR-75-30)
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Concentration:1 μM, 5 μM, 10 μM
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Incubation Time:24 h
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Result:Reduced metabolic activity in all tested ER-positive breast cancer cell lines, with effects more pronounced than unmodified Fisetin (HY-N0182) at all concentrations.
Showed less sensitivity in normal BJ fibroblasts and MCF10F cells compared to breast cancer cells.
Chemical Information
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CAS No. 3106880-06-9
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Molecular Weight 936.76
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Formula C52H42IO7P
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SMILES
O=C(C)OC1=C(C2=CC3=C(OC(C4=CC=CC=C4)(C5=CC=CC=C5)O3)C=C2)OC6=CC(OCCCC[P+](C7=CC=CC=C7)(C8=CC=CC=C8)C9=CC=CC=C9)=CC=C6C1=O.[I-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Mito-fisetin mF7 Related Classifications
HY-185559 Related Classifications
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