BM-962
Based on 1 Customer Validation
BM-962 (Compound 31) is a potent small-molecule inhibitor of Bcl-2 with an IC50 value of 4 nM (Ki=0.8 nM) and Bcl-xL with an IC50 value of 3.9 nM (Ki <1 nM). BM-962 inhibits the cell growth in H1417 and H146 cell lines with IC50 values of 9 and 13 nM, respectively. BM-962 is promising for research of cancers.
For research use only. We do not sell to patients.
- Purity: 99.10%
- CAS No.: 1391107-57-5
- Formula: C53H58ClF3N6O7S3
- Molecular Weight:1079.71
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Anti-Blood Cancer Compound Library
HY-L079
-
Mitochondria-Targeted Compound Library
HY-L089
-
Anti-Hematopathy Compound Library
HY-L171
-
Anti-Ovarian Cancer Compound Library
HY-L173
-
Mitophagy Compound Library
HY-L180
-
Bioactive Compound Library Max
HY-L181
-
Bioactive Compound Library
HY-L001
-
High-Throughput Bioactive Compound Library
HY-L205
-
Apoptosis Compound Library
HY-L003
-
Anti-Cancer Compound Library
HY-L025
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| NCI-H1417 | IC50 |
9 nM
Compound: 31
|
Cytotoxicity against human H1417 cells assessed as growth inhibition after 4 days by WST-8 assay
Cytotoxicity against human H1417 cells assessed as growth inhibition after 4 days by WST-8 assay
|
[PMID: 23030453] |
| NCI-H146 | IC50 |
13 nM
Compound: 31
|
Cytotoxicity against human NCI-H146 cells assessed as growth inhibition after 4 days by WST-8 assay
Cytotoxicity against human NCI-H146 cells assessed as growth inhibition after 4 days by WST-8 assay
|
[PMID: 23030453] |
Chemical Information
-
CAS No. 1391107-57-5
-
Appearance Solid
-
Molecular Weight 1079.71
-
Formula C53H58ClF3N6O7S3
-
Color White to off-white
-
SMILES
OC(C1=C(C)N(C(C)C)C(C2=CC=C(C=C2)Cl)=C1C3=CC(N4CCN(C5=CC=C(C=C5)NS(=O)(C6=CC(S(C(F)(F)F)(=O)=O)=C(C=C6)N[C@@H](CSC7=CC=CC=C7)CCN8CCC(CC8)O)=O)CC4)=CC=C3)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 200 mg/mL (185.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
-
Data Sheet (273 KB)
-
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.9262 mL | 4.6309 mL | 9.2617 mL | 23.1544 mL |
| 5 mM | 0.1852 mL | 0.9262 mL | 1.8523 mL | 4.6309 mL | |
| 10 mM | 0.0926 mL | 0.4631 mL | 0.9262 mL | 2.3154 mL | |
| 15 mM | 0.0617 mL | 0.3087 mL | 0.6174 mL | 1.5436 mL | |
| 20 mM | 0.0463 mL | 0.2315 mL | 0.4631 mL | 1.1577 mL | |
| 25 mM | 0.0370 mL | 0.1852 mL | 0.3705 mL | 0.9262 mL | |
| 30 mM | 0.0309 mL | 0.1544 mL | 0.3087 mL | 0.7718 mL | |
| 40 mM | 0.0232 mL | 0.1158 mL | 0.2315 mL | 0.5789 mL | |
| 50 mM | 0.0185 mL | 0.0926 mL | 0.1852 mL | 0.4631 mL | |
| 60 mM | 0.0154 mL | 0.0772 mL | 0.1544 mL | 0.3859 mL | |
| 80 mM | 0.0116 mL | 0.0579 mL | 0.1158 mL | 0.2894 mL | |
| 100 mM | 0.0093 mL | 0.0463 mL | 0.0926 mL | 0.2315 mL |
BM-962 Related Classifications
HY-169925 Related Classifications
Powered by Bioz