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Bcl-2-like protein 1 Protein, Human (His)

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Based on 1 Customer Validation

Bcl-2-like protein 1 Protein, Human (His) is an important apoptosis regulating gene that codes for both an anti-apoptotic (Bcl-xL) and a pro-apoptotic (Bcl-xS) splice variant.

For research use only. We do not sell to patients.
  • Species: Human
  • Source: E. coli
  • Storage:
    Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
  • Experimental Validation Results for Bcl-2-like protein 1 Protein, Human (His)
  • Bcl-2-like protein 1 Protein, Human (His) Product Image
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Technical Parameters
  • Product Properties
  • Documentation
  • References
  • Help & FAQs
Top Publications Citing

Use of MCE Products

Biological Activity

Description

Bcl-2-like protein 1 Protein, Human (His) is an important apoptosis regulating gene that codes for both an anti-apoptotic (Bcl-xL) and a pro-apoptotic (Bcl-xS) splice variant[1].

Background

BCL2L1 is functionally involved in several cancer-related processes and its protein expression is associated with 20q gain. BCL2L1 (BCL2-like 1) belongs to the family of Bcl-2 proteins that are involved in the regulation of the mitochondrial pathway of apoptosis by controlling the release of proapoptotic factors from the mitochondrion[1].

MCE Validation Data

  • Purity - SDS-PAGE

    Purity - SDS-PAGE

    ≥ 95%, as determined by reducing SDS-PAGE.

Technical Parameters

  • Species Human
  • Source E. coli
  • Tag C-6*His
  • Accession

    Q07817 (M1-R212)

  • Gene ID
    598  [NCBI]
  • Molecular Construction
    • N-term
    • B2CL1 (M1-R212)
      Accession # Q07817
    • 6*His
    • C-term
  • Protein Length

    Partial

  • Synonyms

    BCL2L1; Bcl-X; BCL2 Like 1; Protein Phosphatase 1, Regulatory Subunit 52; BCL2L; Bcl-XL; BCLX; Bcl-XS; Apoptosis Regulator Bcl-X; BCL-XL/S; Bcl-2-Like Protein 1; Bcl2-L-1; PPP1R52

  • AA Sequence

    MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNR

  • Predicted Molecular Mass

    24.9 kDa

  • Molecular Weight

    Approximately 29 kDa, based on SDS-PAGE under reducing conditions.

  • Purity

    ≥ 95%, as determined by reducing SDS-PAGE.

Product Properties

Appearance

Solution

Formulation

Supplied as a 0.22 μm filter solution of 20 mM HEPES, 50 mM KCl, 20% Glycerol, pH 7.5.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Storage & Stability

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping

Shipping with dry ice.

References

[1]. Anke H Sillars-Hardebol, et al. BCL2L1 has a functional role in colorectal cancer and its protein expression is associated with chromosome 20q gain. J Pathol. 2012 Feb;226(3):442-50. [Content Brief]

Calculators

Reconstitution Calculator

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The Specific Activity Calculator Equation
  • Specific Activity (Unit/mg)
  • Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) Specific Activity (Unit/mg)
Unit/mg
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MOQ
Minimum order quantity
100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • 1/16

    MedChemExpress Validation
     ≥ 95%, as determined by reducing SDS-PAGE.

  • Bcl-2-like protein 1 Protein, Human (His) Product Image
    1/16
  • Experimental Validation Results for Bcl-2-like protein 1 Protein, Human (His)
  • Bcl-2-like protein 1 Protein, Human (His) Product Image