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  3. Murizatoclax

Murizatoclax (Synonyms: AMG 397)

Cat. No.: HY-109184
Handling Instructions

Murizatoclax (AMG 397) is a potent, selective and orally active inhibitor of myeloid leukemia 1 (MCL-1) inhibitor, with a Ki of 15 pM. Murizatoclax competitive binds to the BH3-binding groove of MCL1 with pro-apoptotic BCL-2 family members. Murizatoclax can be used for the research of cancer.

For research use only. We do not sell to patients.

Murizatoclax Chemical Structure

Murizatoclax Chemical Structure

CAS No. : 2245848-05-7

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Description

Murizatoclax (AMG 397) is a potent, selective and orally active inhibitor of myeloid leukemia 1 (MCL-1) inhibitor, with a Ki of 15 pM. Murizatoclax competitive binds to the BH3-binding groove of MCL1 with pro-apoptotic BCL-2 family members. Murizatoclax can be used for the research of cancer[1][2].

IC50 & Target[1]

MCL1

15 pM (Ki)

In Vitro

AMG 397 potently disrupts the interaction between MCL1 and BIM in OPM2 cells, induces clear increases in Caspase-3/7 activity within one hour[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Murizatoclax (25-50 mg/kg; p.o. once or twice weekly) exhibits significant tumor regressions in mice bearing OPM2 xenografts[2].
Murizatoclax (10-60 mg/kg; p.o. twice weekly) achieves 47% MOLM-13 orthotopic tumor growth inhibition (TGI), 99% TGI and 75% regression at the dose of 10, 30 and 60 mg/kg, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

765.44

Formula

C₄₂H₅₇ClN₄O₅S

CAS No.
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Murizatoclax
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