2. Others Apoptosis
  3. Reference Standards Bcl-2 Family
  4. Murizatoclax (Standard)

Murizatoclax (Standard)  (Synonyms: AMG 397 (Standard))

Cat. No.: HY-109184R
Handling Instructions Technical Support

Murizatoclax (Standard) is the analytical standard of Murizatoclax (HY-109184). This product is intended for research and analytical applications. Murizatoclax (AMG 397) is a potent, selective and orally active inhibitor of myeloid leukemia 1 (MCL-1) inhibitor, with a Ki of 15 pM. Murizatoclax competitive binds to the BH3-binding groove of MCL1 with pro-apoptotic BCL-2 family members. Murizatoclax can be used for the research of cancer.

For research use only. We do not sell to patients.

Murizatoclax (Standard)

Murizatoclax (Standard) Chemical Structure

CAS No. : 2245848-05-7

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Information

Murizatoclax (Standard) is the analytical standard of Murizatoclax (HY-109184). This product is intended for research and analytical applications. Murizatoclax (AMG 397) is a potent, selective and orally active inhibitor of myeloid leukemia 1 (MCL-1) inhibitor, with a Ki of 15 pM. Murizatoclax competitive binds to the BH3-binding groove of MCL1 with pro-apoptotic BCL-2 family members. Murizatoclax can be used for the research of cancer.

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Molecular Weight

765.44

Formula

C42H57ClN4O5S
CAS No.
SMILES

O=C(C(C=C1)=CC2=C1OC[C@]3(CCCC4=C3C=CC(Cl)=C4)CN2C[C@@]5([H])[C@](CC5)([H])[C@](CN6C[C@](CCCC7)([H])N7CC6)(OC)/C=C/C[C@H](C)[C@H]8C)NS8(=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Murizatoclax (Standard) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Murizatoclax (Standard)2245848-05-7AMG 397 (Standard)Reference StandardsBcl-2 FamilymyeloidleukemiaMCL-1BH3cancerInhibitorinhibitorinhibit

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