BI1071
Based on 1 Customer Validation
BI1071 is an orally active Nur77-Bcl-2 apoptotic pathway modulator. BI1071 can bind to Nur77-LBD protein with a Kd of 0.17 μM. BI1071 can activate Nur77 signaling and induce apoptosis by translocating to mitochondria where it interacts with Bcl-2. BI1071 can inhibit tumor growth in SW620 xenograft mice model. BI1071 can be used for research of colon cancer.
For research use only. We do not sell to patients.
- Purity: 98.93%
- Formula: C25H19F3N2O3S
- Molecular Weight:484.49
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Nuclear Hormone Receptor 4A/NR4A Isoforms
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Biological Activity
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Nur77/NR4A1 |
Bcl-2 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BT-549 | IC50 |
0.17 μM
Compound: BI1071; 8n
|
Cytotoxicity against human BT-549 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay
Cytotoxicity against human BT-549 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay
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[PMID: 33279290] |
| HCT-116 | IC50 |
0.27 μM
Compound: BI1071; 8n
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Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay
Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay
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[PMID: 33279290] |
| MCF-10A | IC50 |
4.29 μM
Compound: BI1071; 8n
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Cytotoxicity against human MCF-10A cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay
Cytotoxicity against human MCF-10A cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay
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[PMID: 33279290] |
| MDA-MB-231 | IC50 |
0.22 μM
Compound: BI1071; 8n
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Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay
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[PMID: 33279290] |
| NCM460 | IC50 |
6.84 μM
Compound: BI1071; 8n
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Cytotoxicity against human NCM460 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay
Cytotoxicity against human NCM460 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay
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[PMID: 33279290] |
| SW-620 | IC50 |
0.18 μM
Compound: BI1071; 8n
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Cytotoxicity against human SW-620 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay
Cytotoxicity against human SW-620 cells assessed as inhibition of cell growth measured after 24 hrs by MTT assay
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[PMID: 33279290] |
Chemical Information
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Appearance Solid
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Molecular Weight 484.49
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Formula C25H19F3N2O3S
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Color Orange to red
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SMILES
FC(C1=CC=C([C+](C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1)(F)F.CS(=O)([O-])=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : 100 mg/mL (206.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0640 mL | 10.3201 mL | 20.6403 mL | 51.6007 mL |
| 5 mM | 0.4128 mL | 2.0640 mL | 4.1281 mL | 10.3201 mL | |
| 10 mM | 0.2064 mL | 1.0320 mL | 2.0640 mL | 5.1601 mL | |
| 15 mM | 0.1376 mL | 0.6880 mL | 1.3760 mL | 3.4400 mL | |
| 20 mM | 0.1032 mL | 0.5160 mL | 1.0320 mL | 2.5800 mL | |
| 25 mM | 0.0826 mL | 0.4128 mL | 0.8256 mL | 2.0640 mL | |
| 30 mM | 0.0688 mL | 0.3440 mL | 0.6880 mL | 1.7200 mL | |
| 40 mM | 0.0516 mL | 0.2580 mL | 0.5160 mL | 1.2900 mL | |
| 50 mM | 0.0413 mL | 0.2064 mL | 0.4128 mL | 1.0320 mL | |
| 60 mM | 0.0344 mL | 0.1720 mL | 0.3440 mL | 0.8600 mL | |
| 80 mM | 0.0258 mL | 0.1290 mL | 0.2580 mL | 0.6450 mL | |
| 100 mM | 0.0206 mL | 0.1032 mL | 0.2064 mL | 0.5160 mL |
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