1. Apoptosis
  2. Bcl-2 Family
  3. Navitoclax dihydrochloride

Navitoclax dihydrochloride  (Synonyms: ABT-263 dihydrochloride)

Cat. No.: HY-10087A1
Handling Instructions

Navitoclax (ABT-263) dihydrochloride is an orally active Bcl-2 inhibitor that binds to various Bcl-2 family proteins, including Bcl-xL, Bcl-2, and Bcl-w, with a Ki value of less than 1 nM. Navitoclax dihydrochloride can be used in cancer research.

For research use only. We do not sell to patients.

Navitoclax dihydrochloride Chemical Structure

Navitoclax dihydrochloride Chemical Structure

CAS No. : 1093851-28-5

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  
Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of Navitoclax dihydrochloride:

Other Forms of Navitoclax dihydrochloride:

Top Publications Citing Use of Products

83 Publications Citing Use of MCE Navitoclax dihydrochloride

Proliferation Assay
WB

    Navitoclax dihydrochloride purchased from MedChemExpress. Usage Cited in: Cell Death Dis. 2018 Sep 24;9(10):986.  [Abstract]

    Cells are treated with 25 nM siRNA for 48 hours followed by 1 μM ABT-263 for 36 hours.

    Navitoclax dihydrochloride purchased from MedChemExpress. Usage Cited in: ACS Med Chem Lett. 2015 Jun 22;6(8):948-52.  [Abstract]

    Combination treatment. (a) Comparison of AZD-8055 and ABT-263 treatment in all cell lines. Red indicates sensitivity, while blue indicates resistance. (b) Depiction of synergism where the values shown are excess over Bliss Independence, a prediction of inhibition without synergism. Increased synergism is evident by an increased number, shown in red, while negative numbers in blue represent an antagonistic effect.

    View All Bcl-2 Family Isoform Specific Products:

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Navitoclax (ABT-263) dihydrochloride is an orally active Bcl-2 inhibitor that binds to various Bcl-2 family proteins, including Bcl-xL, Bcl-2, and Bcl-w, with a Ki value of less than 1 nM. Navitoclax dihydrochloride can be used in cancer research[1].

    Molecular Weight

    1047.53

    Formula

    C47H57Cl3F3N5O6S3

    CAS No.
    SMILES

    O=C(C1=CC=C(N2CCN(CC2)CC3=C(CCC(C)(C3)C)C4=CC=C(Cl)C=C4)C=C1)NS(=O)(C5=CC=C(C(S(=O)(C(F)(F)F)=O)=C5)N[C@H](CCN6CCOCC6)CSC7=CC=CC=C7)=O.Cl.Cl

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    Purity & Documentation
    References
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.
    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product Name

     

    Salutation

    Applicant Name *

     

    Email Address *

    Phone Number *

     

    Organization Name *

    Department *

     

    Requested quantity *

    Country or Region *

         

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product Name:
    Navitoclax dihydrochloride
    Cat. No.:
    HY-10087A1
    Quantity:
    MCE Japan Authorized Agent: