1. Acids and Aldehydes
  2. 23-Hydroxybetulinic acid

23-Hydroxybetulinic acid (Synonyms: Anemosapogenin)

Cat. No.: HY-N0566 Purity: 98.32%
Handling Instructions

23-hydroxybetulinic acid is one of the bioactive components responsible for its anticancer activity.

For research use only. We do not sell to patients.

23-Hydroxybetulinic acid Chemical Structure

23-Hydroxybetulinic acid Chemical Structure

CAS No. : 85999-40-2

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5 mg USD 100 In-stock
Estimated Time of Arrival: December 31
10 mg USD 170 In-stock
Estimated Time of Arrival: December 31
25 mg USD 310 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

23-hydroxybetulinic acid is one of the bioactive components responsible for its anticancer activity. In vitro: 23-hydroxybetulinic acid also shows different proliferation inhibitory activity against B16, HeLa, and HUVEC, with the IC50 value of 78.5, 80, and 94.8 uM, respectively. 23-hydroxybetulinic acid can promote cell cycle arrest at S phase and induce apoptosis via intrinsic pathway. 23-hydroxybetulinic acid disrupts mitochondrial membrane potential significantly (p<0.01) and selectively downregulates the levels of Bcl-2, survivin and upregulates Bax, cytochrome C, cleaved caspase-9 23-hydroxybetulinic acid can induce apoptosis in K562 cells. [1] 23-hydroxybetulinic acid enhances sensitivity of doxorubicin (DOX, ADR) on MCF-7/ADR cell lines, indicating its potential to be developed as a novel MDR modulator.[2] 23-HBA significantly improve the sensitivity of the tumor to doxorubicin. [3]

Molecular Weight

472.70

Formula

C₃₀H₄₈O₄

CAS No.

85999-40-2

SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (211.55 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1155 mL 10.5775 mL 21.1551 mL
5 mM 0.4231 mL 2.1155 mL 4.2310 mL
10 mM 0.2116 mL 1.0578 mL 2.1155 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.29 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

23-Hydroxybetulinic acidAnemosapogeninOthersInhibitorinhibitorinhibit

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Product Name:
23-Hydroxybetulinic acid
Cat. No.:
HY-N0566
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