1. Acids and Aldehydes

23-Hydroxybetulinic acid (Synonyms: Anemosapogenin)

Cat. No.: HY-N0566
Handling Instructions

23-hydroxybetulinic acid is one of the bioactive components responsible for its anticancer activity.

For research use only. We do not sell to patients.

23-Hydroxybetulinic acid Chemical Structure

23-Hydroxybetulinic acid Chemical Structure

CAS No. : 85999-40-2

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10 mg USD 480 Get quote

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  • Biological Activity

  • Protocol

  • Technical Information

  • References

Description

23-hydroxybetulinic acid is one of the bioactive components responsible for its anticancer activity. In vitro: 23-hydroxybetulinic acid also shows different proliferation inhibitory activity against B16, HeLa, and HUVEC, with the IC50 value of 78.5, 80, and 94.8 uM, respectively. 23-hydroxybetulinic acid can promote cell cycle arrest at S phase and induce apoptosis via intrinsic pathway. 23-hydroxybetulinic acid disrupts mitochondrial membrane potential significantly (p<0.01) and selectively downregulates the levels of Bcl-2, survivin and upregulates Bax, cytochrome C, cleaved caspase-9 23-hydroxybetulinic acid can induce apoptosis in K562 cells. [1] 23-hydroxybetulinic acid enhances sensitivity of doxorubicin (DOX, ADR) on MCF-7/ADR cell lines, indicating its potential to be developed as a novel MDR modulator.[2] 23-HBA significantly improve the sensitivity of the tumor to doxorubicin. [3]

References
Molecular Weight

472.7

Formula

C₃₀H₄₈O₄

CAS No.

85999-40-2

SMILES

OC([[email protected]]1(CC[[email protected]]2C(C)=C)[[email protected]@]2([H])[[email protected]](CC[[email protected]@]3([H])[[email protected]]4(CC[[email protected]]5([H])[[email protected]@]3(CC[[email protected]](O)[[email protected]@]5(C)CO)C)C)([H])[[email protected]@]4(C)CC1)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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23-Hydroxybetulinic acid
Cat. No.:
HY-N0566
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