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Cat. No.: HY-144428

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Bcl-2/Mcl-1-IN-2

Bcl-2/Mcl-1-IN-2 (compound 2) is a Bcl-2/Mcl-1 inhibitor, with K_is of 0.88 μM and 4.70 μM for Mcl-1 and Bcl-2, respectively. Bcl-2/Mcl-1-IN-2 can be used for the research of cancer.

For research use only. We do not sell to patients.

CAS No.: 2673361-07-2

Formula: C₂₆H₂₄ClNO₃

Molecular Weight:433.93

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Bcl-2/Mcl-1-IN-2 Chemical Structure

CAS No.: 2673361-07-2

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Data Download

Data Sheet (269 KB)

Handling Instructions (2659 KB)

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Biological Activity

Chemical Information

Purity & Documentation

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Help & FAQs

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

All Bcl-2 Family Isoforms
More

Bcl-2

Bcl-xL

Bcl-W

Mcl-1

Bfl-1

Bcl-B

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Bim

BNIP3

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Biological Activity

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Bioz

Biological Activity

Description

Bcl-2/Mcl-1-IN-2 (compound 2) is a Bcl-2/Mcl-1 inhibitor, with K_is of 0.88 μM and 4.70 μM for Mcl-1 and Bcl-2, respectively. Bcl-2/Mcl-1-IN-2 can be used for the research of cancer^[1].

IC₅₀ & Target^[1]

Mcl-1

0.88 μM (Ki)

Bcl-2

4.70 μM (Ki)

All Bcl-2 Family Isoforms :

Bcl-2

Bcl-xL

Bcl-W

Mcl-1

Bfl-1

Bcl-B

Bax

Bak

Bim

BNIP3

Bad

Chemical Information

CAS No. 2673361-07-2

Molecular Weight 433.93

Formula C₂₆H₂₄ClNO₃

SMILES

O=C(O)C1=CC=CC=C1C2=CC=CC3=C2C=CN3CCCOC4=CC(C)=C(Cl)C(C)=C4

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)

COA (2659 KB)

Elemental Analysis Report (2659 KB)

HNMR (2659 KB)

CNMR (2659 KB)

RP-HPLC (2659 KB)

NP-HPLC (2659 KB)

MS (2659 KB)

LCMS (2659 KB)

IR (2659 KB)

GC (2659 KB)

OR (2659 KB)

SDS-PAGE (2659 KB)

SEC-HPLC (2659 KB)

Other Report (2659 KB)

Handling Instructions (2659 KB)

References

[1]. Niu Q, et, al. Design, synthesis and biological evaluation of dual Bcl-2/Mcl-1 inhibitors bearing 2-(1H-indol-4-yl)benzoic acid scaffold. Bioorg Med Chem Lett. 2021 Sep 1;47:128215. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bcl-2/Mcl-1-IN-2 Related Classifications

HY-144428 Related Classifications

Apoptosis

Bcl-2 Family

Disease Areas

Cancer

Cancer

Cancer Targeted Therapy Cancer Metabolism and Metastasis

Powered by Bioz See more details on Bioz

Keywords

Bcl-2/Mcl-1-IN-2
2673361-07-2
Bcl-2 Family
Inhibitor
inhibitor
inhibit

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ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社

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