METTL3-IN-11
METTL3-IN-11 is an excellent, selective METTL3 inhibitor (IC50 = 45.31 nM). METTL3-IN-11 exhibits high selectivity towards METTL3 compared to DNMT1, EZH1, MLL1, and PRMT1. METTL3-IN-11 reduces the m6A level of total RNA in MOLM-13 and SKOV3 cells, induces cell apoptosis, and inhibits cell migration. METTL3-IN-11 can reduce the expression of m6A downstream target genes (c-MYC and BCL2). METTL3-IN-11 can be used for the study of ovarian cancer and acute myeloid leukemia.
For research use only. We do not sell to patients.
- CAS No.: 3069369-05-4
- Formula: C26H28N6O3
- Molecular Weight:472.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Bcl-2 |
METTL3-IN-11 (Compound 30t) exhibits good antiproliferative activity in both SKOV3 (IC50 = 6.42 μM) and MOLM-13 (IC50 = 12.34 μM) cells, while showing low toxicity in LO2 and HK2 cells, with the survival rate of HK2 cells at 25 μM and 50 μM being significantly higher than that of the positive control STM2457[1].
METTL3-IN-11 (5-15 μM) reduces the m6A levels on total RNA in a dose-dependent manner in SKOV3 and MOLM-13 cells[1].
METTL3-IN-11 (10-25 μM, 48 h) significantly inhibits the migratory capability of SKOV3 cells and induces apoptosis[1].
METTL3-IN-11 (10-25 μM, 48 h) does not affect the expression level of METTL3 protein, but it downregulates the protein expression of downstream target genes of m6A (such as c-MYC and BCL2) in SKOV3 and MOLM-13 cells in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SKOV3 cells
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Concentration:10 μM, 25 μM
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Incubation Time:48 h
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Result:Significantly inhibits the migratory capability of SKOV3 cells.
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Cell Line:SKOV3 cells, MOLM-13 cells
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Concentration:10 μM, 25 μM
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Incubation Time:48 h
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Result:Did not affect the expression level of METTL3 protein.
Downregulated the protein expression of downstream target genes of m6A (such as c-MYC and BCL2).
| Species | Dose | Route | T1/2 | MRT | AUC0-∞ | AUC0-t | Cmax | Tmax | F | CL/F |
|---|---|---|---|---|---|---|---|---|---|---|
| Rat | 1 mg/kg | i.v. | 9.92 h | 8.96 h | 204.4 ng·h/mL | 176.07 ng·h/mL | 168.27 ng/mL | 0.083 h | / | / |
| Rat | 3 mg/kg | p.o. | 5.88 h | 4.71 h | 106.96 ng·h/mL | 102.55 ng·h/mL | 40.84 ng/mL | 2 h | 17.44 % | 0.028086 h |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SKOV3 cells were subcutaneously inoculated into the right flank of female BALB/c mice (4–5 weeks old)[1].
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Dosage:50 mg/kg
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Administration:I.p., once daily for 2 weeks
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Result:Significantly inhibited tumor growth.
No significant difference was observed in the body weight.
Chemical Information
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CAS No. 3069369-05-4
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Molecular Weight 472.54
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Formula C26H28N6O3
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SMILES
OC1=C(CN2C=NC(C(NCC3=CN4C(C=CC(CNCC5CCC5)=C4)=N3)=O)=CC2=O)C=CC=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
METTL3-IN-11 Related Classifications
HY-178446 Related Classifications
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