3069369-05-4
Chemical Structure
METTL3-IN-11
- CAS No.: 3069369-05-4
- Formula:C26H28N6O3
- Molecular Weight:472.54
InChIKey: RDOQXOCVQLGNKM-UHFFFAOYSA-N
SMILES: OC1=C(CN2C=NC(C(NCC3=CN4C(C=CC(CNCC5CCC5)=C4)=N3)=O)=CC2=O)C=CC=C1
Biological Activity: METTL3-IN-11 is an excellent, selective METTL3 inhibitor (IC50 = 45.31 nM). METTL3-IN-11 exhibits high selectivity towards METTL3 compared to DNMT1, EZH1, MLL1, and PRMT1. METTL3-IN-11 reduces the m6A level of total RNA in MOLM-13 and SKOV3 cells, induces cell apoptosis, and inhibits cell migration. METTL3-IN-11 can reduce the expression of m6A downstream target genes (c-MYC and BCL2). METTL3-IN-11 can be used for the study of ovarian cancer and acute myeloid leukemia[1].
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METTL3-IN-11 | METTL3-IN-11 is an excellent, selective METTL3 inhibitor (IC50 = 45.31 nM). METTL3-IN-11 exhibits high selectivity towards METTL3 compared to DNMT1, EZH1, MLL1, and PRMT1. METTL3-IN-11 reduces the m6A level of total RNA in MOLM-13 and SKOV3 cells, induces cell apoptosis, and inhibits cell migration. METTL3-IN-11 can reduce the expression of m6A downstream target genes (c-MYC and BCL2). METTL3-IN-11 can be used for the study of ovarian cancer and acute myeloid leukemia. | |||||||||||||||||||||
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Keywords
