VEGFR-2-IN-58
VEGFR-2-IN-58 (Compound 7b) inhibits VEGFR-2 with an IC50 of 42.5 nM. VEGFR-2-IN-58 displays selective cytotoxicity against cancer cells. VEGFR-2-IN-58 shows cellular growth arrest at the G2/M phase in cancer cells. VEGFR-2-IN-58 induces cancer cells Apoptosis, increasing BAX expression and reducing Bcl2 expression. VEGFR-2-IN-58 inhibits wound closure in cancer cells.
For research use only. We do not sell to patients.
- Formula: C24H16ClN3O
- Molecular Weight:397.86
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All VEGFR Isoforms
More
Biological Activity
|
VEGFR2 42.5 nM (IC50) |
VEGFR-2-IN-58 inhibits HepG2, MCF-7, A549, HT-29, PC3 and WI-38 cells proliferation with IC50s of 7.28, 6.72, 6.66, 8.51, 14.5, 30 μM, respectively[1].
VEGFR-2-IN-58 (8.51 μM, 24 h) shows cellular growth arrest at the G2/M phase and induces apoptosis in the HT-29 cell line[1].
VEGFR-2-IN-58 (0.85, 4.26 μM, 48 h) exerts a noticeable inhibition in wound closure in HT-29 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:HT-29 cells
-
Concentration:0.85,4.26, 8.51 μM
-
Incubation Time:24 h
-
Result:Reduced p-VEGFR-2 expression in a dose-dependent manner.
-
Cell Line:HT-29 cells
-
Concentration:8.51 μM
-
Incubation Time:24 h
-
Result:Caused cell growth arrest at G2/M based on accumulation of DNA content inHT-29 cells.
-
Cell Line:HT-29 cells
-
Concentration:8.51 μM
-
Incubation Time:24 h
-
Result:Elevated apoptotic gene BAX expression and suppressed anti-apoptotic gene Bcl-2 expression.
Elevated total apoptosis percentage.
Chemical Information
-
Molecular Weight 397.86
-
Formula C24H16ClN3O
-
SMILES
N#CC1=C(/N=C/NC2=CC=C(Cl)C=C2)OC(C3=CC=CC=C3)=C1C4=CC=CC=C4
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)