BCL2L2 Antibody (YA4406)
(Synonyms: BCLW; BCL-W; PPP1R51; BCL2-L-2)
Based on 1 Customer Validation
BCL2L2 Antibody (YA4406) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to BCL2L2.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
IHC-P, ICC/IF, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|---|
| Dilution Ratio | 1:200-1:1000 | 1:200-1:1000 | 1:200-1:400 | 1:10000 |
Product Details
BCL2L2 Antibody (YA4406) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to BCL2L2.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 23 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 20.7 kDa
Purified recombinant fragment of human BCL2L2 (AA: 6-118) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS with 0.05% sodium azide
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
BCL2L2 transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR)
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Subcellular Localization
Cytoplasm; Nucleus
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Expression
Tissue_specificity:It is most abundantly expressed in the thymus. It is also expressed in both B cells and T cells. High expression is observed in HEK293T cells and insulinomas. High levels of expression are also found in the spleen, ovaries, muscles, and lungs, with the highest expression in muscles. Lower expression is observed in the brain, colon, heart, kidneys, prostate, small intestine, and stomach. Weak expression is observed in the liver and pancreas. -
Subunit
Binds, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1 (PubMed:15454081). 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction (PubMed:15454081). Interaction, via its C-terminal, with TAF4, enhances recruitment of TAF4 to CREB1 (PubMed:15454081). Interacts with SIK2 (PubMed:15454081). Interacts with 14-3-3 proteins, YWHAB and YWHAG (PubMed:15454081, PubMed:18626018). Interacts (probably when phosphorylated at Ser-171) with YWHAE (PubMed:30611118). Interacts with calmodulin-dependent catalytic subunit PPP3CA/calcineurin A (PubMed:15454081, PubMed:30611118). Interaction with COP1 mediates nuclear export and degradation of CRTC2 (By similarity)
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SwissProt ID
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Synonyms
BCLW; BCL-W; PPP1R51; BCL2-L-2
Documentation
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Data Sheet (231 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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User Guide for Antibodies (1077 KB)
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