BCL2L2 - BCL2 like 2 Gene
Also Known as BCLW; BCL-W; PPP1R51; BCL2-L-2
Species: Homo sapiens
About BCL2L2
This gene has 10 transcripts (splice variants), 61 orthologues and 8 paralogues. Ubiquitous expression in brain (RPKM 35.0), fat (RPKM 31.5) and 25 other tissues.
Summary
This gene encodes a member of the Bcl-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell Apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]
BCL2L2 Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_004050.5 | NP_004041.2 | bcl-2-like protein 2 |
| NM_001199839.2 | NP_001186768.2 | bcl-2-like protein 2 |
BCL2L2 Protein Structure
BH4: Bcl-2 homology region 4 (7 - 31)
Bcl-2: Apoptosis regulator proteins, Bcl-2 family (46 - 144)
- 0
- 100
- 193 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
bcl-2-like protein 2 |
|
BCL2L2 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
BCL2L2 | Q92843 | CISD2 | Homo sapiens | Q8N5K1 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | CISD2 | Homo sapiens | Q8N5K1 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | SGPL1 | Homo sapiens | O95470 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | SGPL1 | Homo sapiens | O95470 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | TMX1 | Homo sapiens | Q9H3N1 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | TMX1 | Homo sapiens | Q9H3N1 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | TMX1 | Homo sapiens | Q9H3N1 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | RTL10 | Homo sapiens | Q7L3V2 | 23055042 | |
|
Intra
|
BCL2L2 | Q92843 | MGST2 | Homo sapiens | Q99735 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | MGST2 | Homo sapiens | Q99735 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | MGST2 | Homo sapiens | Q99735 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | TEX11 | Homo sapiens | Q8IYF3-3 | 27107012 | |
|
Intra
|
BCL2L2 | Q92843 | TEX11 | Homo sapiens | Q8IYF3-3 | 27107012 | |
|
Intra
|
BCL2L2 | Q92843 | GPX8 | Homo sapiens | Q8TED1 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | GPX8 | Homo sapiens | Q8TED1 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | TMEM179B | Homo sapiens | Q7Z7N9 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | TMEM179B | Homo sapiens | Q7Z7N9 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | GPR151 | Homo sapiens | Q8TDV0 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | GPR151 | Homo sapiens | Q8TDV0 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | KCNJ6 | Homo sapiens | P48051 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | KCNJ6 | Homo sapiens | P48051 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | STOM | Homo sapiens | P27105 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | STOM | Homo sapiens | P27105 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | APOC1 | Homo sapiens | P02654 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | APOC1 | Homo sapiens | P02654 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | BNIP5 | Homo sapiens | P0C671 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | BNIP5 | Homo sapiens | P0C671 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | FGF14 | Homo sapiens | Q92915-2 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | FGF14 | Homo sapiens | Q92915-2 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | FGF14 | Homo sapiens | Q92915-2 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | SLC39A2 | Homo sapiens | Q9NP94 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | SLC39A2 | Homo sapiens | Q9NP94 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | SLC39A2 | Homo sapiens | Q9NP94 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | SLC39A6 | Homo sapiens | Q13433-2 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | SLC39A6 | Homo sapiens | Q13433-2 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | C10orf67 | Homo sapiens | Q8IYJ2-2 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | C10orf67 | Homo sapiens | Q8IYJ2-2 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | SLC35E3 | Homo sapiens | Q7Z769 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | SLC35E3 | Homo sapiens | Q7Z769 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | MUC1 | Homo sapiens | P15941-11 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | MUC1 | Homo sapiens | P15941-11 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | SLC35C2 | Homo sapiens | Q9NQQ7-3 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | SLC35C2 | Homo sapiens | Q9NQQ7-3 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | SLC35C2 | Homo sapiens | Q9NQQ7-3 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | CHODL | Homo sapiens | Q9H9P2 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | CHODL | Homo sapiens | Q9H9P2 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | CHODL | Homo sapiens | Q9H9P2 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | BHLHA9 | Homo sapiens | Q7RTU4 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | BHLHA9 | Homo sapiens | Q7RTU4 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | RHBDD2 | Homo sapiens | Q6NTF9-3 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | RHBDD2 | Homo sapiens | Q6NTF9-3 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | ERVFRD-1 | Homo sapiens | P60508 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | ERVFRD-1 | Homo sapiens | P60508 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | SUSD3 | Homo sapiens | Q96L08 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | SUSD3 | Homo sapiens | Q96L08 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | SUSD3 | Homo sapiens | Q96L08 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | APOC4 | Homo sapiens | P55056 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | APOC4 | Homo sapiens | P55056 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | ATP5PF | Homo sapiens | P18859 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | ATP5PF | Homo sapiens | P18859 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | LRP10 | Homo sapiens | Q7Z4F1 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | LRP10 | Homo sapiens | Q7Z4F1 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | GORAB | Homo sapiens | Q5T7V8 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | GORAB | Homo sapiens | Q5T7V8 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | BMF | Homo sapiens | Q96LC9 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | BMF | Homo sapiens | Q96LC9 | 25416956 | |
|
Intra
|
BCL2L2 | Q92843 | BMF | Homo sapiens | Q96LC9 | 25416956 | |
|
Intra
|
BCL2L2 | Q92843 | BMF | Homo sapiens | Q96LC9 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | BMF | Homo sapiens | Q96LC9 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | BMF | Homo sapiens | Q96LC9 | 25416956 | |
|
Intra
|
BCL2L2 | Q92843 | SAR1A | Homo sapiens | Q9NR31 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | SAR1A | Homo sapiens | Q9NR31 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | SAR1A | Homo sapiens | Q9NR31 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | G0S2 | Homo sapiens | P27469 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | G0S2 | Homo sapiens | P27469 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | BAX | Homo sapiens | Q07812 | 17289999 | |
|
Intra
|
BCL2L2 | Q92843 | BAX | Homo sapiens | Q07812 | 21199865 | |
|
Intra
|
BCL2L2 | Q92843 | BAX | Homo sapiens | Q07812 | 33961781 | |
|
Intra
|
BCL2L2 | Q92843 | BID | Homo sapiens | P55957 | 33961781 | |
|
Intra
|
BCL2L2 | Q92843 | BID | Homo sapiens | P55957 | 16697956 | |
|
Intra
|
BCL2L2 | Q92843 | BAK1 | Homo sapiens | Q16611 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | BAK1 | Homo sapiens | Q16611 | 25416956 | |
|
Intra
|
BCL2L2 | Q92843 | BAK1 | Homo sapiens | Q16611 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | BAK1 | Homo sapiens | Q16611 | 25416956 | |
|
Intra
|
BCL2L2 | Q92843 | BBC3 | Homo sapiens | Q9BXH1 | 28514442 | |
|
Intra
|
BCL2L2 | Q92843 | BCL2L11 | Homo sapiens | O43521 | 33961781 | |
|
Intra
|
BCL2L2 | Q92843 | BCL2L11 | Homo sapiens | O43521 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | BCL2L11 | Homo sapiens | O43521 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | TCF4 | Homo sapiens | P15884 | 25416956 | |
|
Intra
|
BCL2L2 | Q92843 | TCF4 | Homo sapiens | P15884 | 25416956 | |
|
Intra
|
BCL2L2 | Q92843 | BAD | Homo sapiens | Q92934 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | BAD | Homo sapiens | Q92934 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | BAD | Homo sapiens | Q92934 | 22000515 | |
|
Intra
|
BCL2L2 | Q92843 | BAD | Homo sapiens | Q92934 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | BIK | Homo sapiens | Q13323 | 27107012 | |
|
Intra
|
BCL2L2 | Q92843 | BIK | Homo sapiens | Q13323 | 27107012 | |
|
Intra
|
BCL2L2 | Q92843 | BIK | Homo sapiens | Q13323 | 27107012 | |
|
Intra
|
BCL2L2 | Q92843 | BIK | Homo sapiens | Q13323 | 27107012 | |
|
Intra
|
BCL2L2 | Q92843 | BIK | Homo sapiens | Q13323 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | BIK | Homo sapiens | Q13323 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | PANX1 | Homo sapiens | Q96RD7 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | PANX1 | Homo sapiens | Q96RD7 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | PANX1 | Homo sapiens | Q96RD7 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | ANKS6 | Homo sapiens | Q68DC2 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | ANKS6 | Homo sapiens | Q68DC2 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | CIDEB | Homo sapiens | Q9UHD4 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | CIDEB | Homo sapiens | Q9UHD4 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | CIDEB | Homo sapiens | Q9UHD4 | 32296183 | |
|
Cross
|
BCL2L2 | Q92843 | Bmf | Mus musculus | Q91ZE9 | 16697956 | |
|
Intra
|
BCL2L2 | Q92843 | TMEM139 | Homo sapiens | Q8IV31 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | TMEM139 | Homo sapiens | Q8IV31 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | CLDN7 | Homo sapiens | O95471 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | CLDN7 | Homo sapiens | O95471 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | FATE1 | Homo sapiens | Q969F0 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | FATE1 | Homo sapiens | Q969F0 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | FATE1 | Homo sapiens | Q969F0 | 25416956 | |
|
Intra
|
BCL2L2 | Q92843 | FATE1 | Homo sapiens | Q969F0 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | KASH5 | Homo sapiens | Q8N6L0 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | KASH5 | Homo sapiens | Q8N6L0 | 27107012 | |
|
Intra
|
BCL2L2 | Q92843 | KASH5 | Homo sapiens | Q8N6L0 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | CD79A | Homo sapiens | P11912 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | CD79A | Homo sapiens | P11912 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | ERGIC3 | Homo sapiens | Q9Y282 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | ERGIC3 | Homo sapiens | Q9Y282 | 32296183 | |
|
Intra
|
BCL2L2 | Q92843 | ERGIC3 | Homo sapiens | Q9Y282 | 32296183 |
Recombinant BCL2L2 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P7653 | Bcl-2-like protein 2 Protein, Human (His) | AAI13523.1 (A2-T172) | ≥ 95%, as determined by reducing SDS-PAGE. |
BCL2L2 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P84709 | BCL2L2 Antibody (YA4406) | IHC-P, ICC/IF, FC, ELISA | Human |
| HY-P84709A | BCL2L2 Antibody (YA4406)(PBS only) | IHC-P, ICC/IF, FC, ELISA | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Blood Platelet Disease |
|
|
| B-Cell Lymphoma |
|
|
| Lung Cancer |
|
|
| Hepatocellular Carcinoma |
|
|
| Burkitt Lymphoma |
|
|
| Leukemia, Acute Myeloid |
|
|
| Lymphoma |
|
|
| Leukemia, Chronic Lymphocytic |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | BCL2L2 | RGD | RGD:620717 |
| Mus musculus | BCL2L2 | MGD | MGI:108052 |
| Bos taurus | BCL2L2 | VGNC | VGNC:55105 |
| Others | BCL2L2 | NCBI |