BCL2L2 - BCL2 like 2 Gene

Also Known as BCLW; BCL-W; PPP1R51; BCL2-L-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 599

About BCL2L2

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:23,306,833-23,311,751 (from NCBI)

This gene has 10 transcripts (splice variants), 61 orthologues and 8 paralogues. Ubiquitous expression in brain (RPKM 35.0), fat (RPKM 31.5) and 25 other tissues.

Summary

This gene encodes a member of the Bcl-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell Apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. [provided by RefSeq, Dec 2010]

BCL2L2 Products (2)

mRNA Protein Name
NM_004050.5 NP_004041.2 bcl-2-like protein 2
NM_001199839.2 NP_001186768.2 bcl-2-like protein 2

BCL2L2 Protein Structure

BH4

BH4: Bcl-2 homology region 4 (7 - 31)

Bcl-2

Bcl-2: Apoptosis regulator proteins, Bcl-2 family (46 - 144)

  • 0
  • 100
  • 193 a.a.
Protein Preferred Names Protein Names

bcl-2-like protein 2

  • apoptosis regulator BCL-W

  • protein phosphatase 1, regulatory subunit 51

BCL2L2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
BCL2L2 Q92843 CISD2 Homo sapiens Q8N5K1 32296183
Intra
BCL2L2 Q92843 CISD2 Homo sapiens Q8N5K1 32296183
Intra
BCL2L2 Q92843 SGPL1 Homo sapiens O95470 32296183
Intra
BCL2L2 Q92843 SGPL1 Homo sapiens O95470 32296183
Intra
BCL2L2 Q92843 TMX1 Homo sapiens Q9H3N1 32296183
Intra
BCL2L2 Q92843 TMX1 Homo sapiens Q9H3N1 32296183
Intra
BCL2L2 Q92843 TMX1 Homo sapiens Q9H3N1 32296183
Intra
BCL2L2 Q92843 RTL10 Homo sapiens Q7L3V2 23055042
Intra
BCL2L2 Q92843 MGST2 Homo sapiens Q99735 32296183
Intra
BCL2L2 Q92843 MGST2 Homo sapiens Q99735 32296183
Intra
BCL2L2 Q92843 MGST2 Homo sapiens Q99735 32296183
Intra
BCL2L2 Q92843 TEX11 Homo sapiens Q8IYF3-3
Y2H
27107012
Intra
BCL2L2 Q92843 TEX11 Homo sapiens Q8IYF3-3 27107012
Intra
BCL2L2 Q92843 GPX8 Homo sapiens Q8TED1 32296183
Intra
BCL2L2 Q92843 GPX8 Homo sapiens Q8TED1 32296183
Intra
BCL2L2 Q92843 TMEM179B Homo sapiens Q7Z7N9 32296183
Intra
BCL2L2 Q92843 TMEM179B Homo sapiens Q7Z7N9 32296183
Intra
BCL2L2 Q92843 GPR151 Homo sapiens Q8TDV0 32296183
Intra
BCL2L2 Q92843 GPR151 Homo sapiens Q8TDV0 32296183
Intra
BCL2L2 Q92843 KCNJ6 Homo sapiens P48051 32296183
Intra
BCL2L2 Q92843 KCNJ6 Homo sapiens P48051 32296183
Intra
BCL2L2 Q92843 STOM Homo sapiens P27105 32296183
Intra
BCL2L2 Q92843 STOM Homo sapiens P27105 32296183
Intra
BCL2L2 Q92843 APOC1 Homo sapiens P02654 32296183
Intra
BCL2L2 Q92843 APOC1 Homo sapiens P02654 32296183
Intra
BCL2L2 Q92843 BNIP5 Homo sapiens P0C671 32296183
Intra
BCL2L2 Q92843 BNIP5 Homo sapiens P0C671 32296183
Intra
BCL2L2 Q92843 FGF14 Homo sapiens Q92915-2 32296183
Intra
BCL2L2 Q92843 FGF14 Homo sapiens Q92915-2 32296183
Intra
BCL2L2 Q92843 FGF14 Homo sapiens Q92915-2 32296183
Intra
BCL2L2 Q92843 SLC39A2 Homo sapiens Q9NP94 32296183
Intra
BCL2L2 Q92843 SLC39A2 Homo sapiens Q9NP94 32296183
Intra
BCL2L2 Q92843 SLC39A2 Homo sapiens Q9NP94 32296183
Intra
BCL2L2 Q92843 SLC39A6 Homo sapiens Q13433-2 32296183
Intra
BCL2L2 Q92843 SLC39A6 Homo sapiens Q13433-2 32296183
Intra
BCL2L2 Q92843 C10orf67 Homo sapiens Q8IYJ2-2 32296183
Intra
BCL2L2 Q92843 C10orf67 Homo sapiens Q8IYJ2-2 32296183
Intra
BCL2L2 Q92843 SLC35E3 Homo sapiens Q7Z769 32296183
Intra
BCL2L2 Q92843 SLC35E3 Homo sapiens Q7Z769 32296183
Intra
BCL2L2 Q92843 MUC1 Homo sapiens P15941-11 32296183
Intra
BCL2L2 Q92843 MUC1 Homo sapiens P15941-11 32296183
Intra
BCL2L2 Q92843 SLC35C2 Homo sapiens Q9NQQ7-3 32296183
Intra
BCL2L2 Q92843 SLC35C2 Homo sapiens Q9NQQ7-3 32296183
Intra
BCL2L2 Q92843 SLC35C2 Homo sapiens Q9NQQ7-3 32296183
Intra
BCL2L2 Q92843 CHODL Homo sapiens Q9H9P2 32296183
Intra
BCL2L2 Q92843 CHODL Homo sapiens Q9H9P2 32296183
Intra
BCL2L2 Q92843 CHODL Homo sapiens Q9H9P2 32296183
Intra
BCL2L2 Q92843 BHLHA9 Homo sapiens Q7RTU4 32296183
Intra
BCL2L2 Q92843 BHLHA9 Homo sapiens Q7RTU4 32296183
Intra
BCL2L2 Q92843 RHBDD2 Homo sapiens Q6NTF9-3 32296183
Intra
BCL2L2 Q92843 RHBDD2 Homo sapiens Q6NTF9-3 32296183
Intra
BCL2L2 Q92843 ERVFRD-1 Homo sapiens P60508 32296183
Intra
BCL2L2 Q92843 ERVFRD-1 Homo sapiens P60508 32296183
Intra
BCL2L2 Q92843 SUSD3 Homo sapiens Q96L08 32296183
Intra
BCL2L2 Q92843 SUSD3 Homo sapiens Q96L08 32296183
Intra
BCL2L2 Q92843 SUSD3 Homo sapiens Q96L08 32296183
Intra
BCL2L2 Q92843 APOC4 Homo sapiens P55056 32296183
Intra
BCL2L2 Q92843 APOC4 Homo sapiens P55056 32296183
Intra
BCL2L2 Q92843 ATP5PF Homo sapiens P18859 32296183
Intra
BCL2L2 Q92843 ATP5PF Homo sapiens P18859 32296183
Intra
BCL2L2 Q92843 LRP10 Homo sapiens Q7Z4F1 32296183
Intra
BCL2L2 Q92843 LRP10 Homo sapiens Q7Z4F1 32296183
Intra
BCL2L2 Q92843 GORAB Homo sapiens Q5T7V8 32296183
Intra
BCL2L2 Q92843 GORAB Homo sapiens Q5T7V8 32296183
Intra
BCL2L2 Q92843 BMF Homo sapiens Q96LC9 32296183
Intra
BCL2L2 Q92843 BMF Homo sapiens Q96LC9 25416956
Intra
BCL2L2 Q92843 BMF Homo sapiens Q96LC9 25416956
Intra
BCL2L2 Q92843 BMF Homo sapiens Q96LC9 32296183
Intra
BCL2L2 Q92843 BMF Homo sapiens Q96LC9 32296183
Intra
BCL2L2 Q92843 BMF Homo sapiens Q96LC9 25416956
Intra
BCL2L2 Q92843 SAR1A Homo sapiens Q9NR31 32296183
Intra
BCL2L2 Q92843 SAR1A Homo sapiens Q9NR31 32296183
Intra
BCL2L2 Q92843 SAR1A Homo sapiens Q9NR31 32296183
Intra
BCL2L2 Q92843 G0S2 Homo sapiens P27469 32296183
Intra
BCL2L2 Q92843 G0S2 Homo sapiens P27469 32296183
Intra
BCL2L2 Q92843 BAX Homo sapiens Q07812 17289999
Intra
BCL2L2 Q92843 BAX Homo sapiens Q07812 21199865
Intra
BCL2L2 Q92843 BAX Homo sapiens Q07812 33961781
Intra
BCL2L2 Q92843 BID Homo sapiens P55957 33961781
Intra
BCL2L2 Q92843 BID Homo sapiens P55957
FPS
16697956
Intra
BCL2L2 Q92843 BAK1 Homo sapiens Q16611 32296183
Intra
BCL2L2 Q92843 BAK1 Homo sapiens Q16611 25416956
Intra
BCL2L2 Q92843 BAK1 Homo sapiens Q16611 32296183
Intra
BCL2L2 Q92843 BAK1 Homo sapiens Q16611 25416956
Intra
BCL2L2 Q92843 BBC3 Homo sapiens Q9BXH1 28514442
Intra
BCL2L2 Q92843 BCL2L11 Homo sapiens O43521 33961781
Intra
BCL2L2 Q92843 BCL2L11 Homo sapiens O43521 32296183
Intra
BCL2L2 Q92843 BCL2L11 Homo sapiens O43521 32296183
Intra
BCL2L2 Q92843 TCF4 Homo sapiens P15884 25416956
Intra
BCL2L2 Q92843 TCF4 Homo sapiens P15884 25416956
Intra
BCL2L2 Q92843 BAD Homo sapiens Q92934 32296183
Intra
BCL2L2 Q92843 BAD Homo sapiens Q92934 32296183
Intra
BCL2L2 Q92843 BAD Homo sapiens Q92934
ITC
22000515
Intra
BCL2L2 Q92843 BAD Homo sapiens Q92934 32296183
Intra
BCL2L2 Q92843 BIK Homo sapiens Q13323
Y2H
27107012
Intra
BCL2L2 Q92843 BIK Homo sapiens Q13323 27107012
Intra
BCL2L2 Q92843 BIK Homo sapiens Q13323
SLC
27107012
Intra
BCL2L2 Q92843 BIK Homo sapiens Q13323 27107012
Intra
BCL2L2 Q92843 BIK Homo sapiens Q13323 32296183
Intra
BCL2L2 Q92843 BIK Homo sapiens Q13323 32296183
Intra
BCL2L2 Q92843 PANX1 Homo sapiens Q96RD7 32296183
Intra
BCL2L2 Q92843 PANX1 Homo sapiens Q96RD7 32296183
Intra
BCL2L2 Q92843 PANX1 Homo sapiens Q96RD7 32296183
Intra
BCL2L2 Q92843 ANKS6 Homo sapiens Q68DC2 32296183
Intra
BCL2L2 Q92843 ANKS6 Homo sapiens Q68DC2 32296183
Intra
BCL2L2 Q92843 CIDEB Homo sapiens Q9UHD4 32296183
Intra
BCL2L2 Q92843 CIDEB Homo sapiens Q9UHD4 32296183
Intra
BCL2L2 Q92843 CIDEB Homo sapiens Q9UHD4 32296183
Cross
BCL2L2 Q92843 Bmf Mus musculus Q91ZE9
FPS
16697956
Intra
BCL2L2 Q92843 TMEM139 Homo sapiens Q8IV31 32296183
Intra
BCL2L2 Q92843 TMEM139 Homo sapiens Q8IV31 32296183
Intra
BCL2L2 Q92843 CLDN7 Homo sapiens O95471 32296183
Intra
BCL2L2 Q92843 CLDN7 Homo sapiens O95471 32296183
Intra
BCL2L2 Q92843 FATE1 Homo sapiens Q969F0 32296183
Intra
BCL2L2 Q92843 FATE1 Homo sapiens Q969F0 32296183
Intra
BCL2L2 Q92843 FATE1 Homo sapiens Q969F0 25416956
Intra
BCL2L2 Q92843 FATE1 Homo sapiens Q969F0 32296183
Intra
BCL2L2 Q92843 KASH5 Homo sapiens Q8N6L0 32296183
Intra
BCL2L2 Q92843 KASH5 Homo sapiens Q8N6L0 27107012
Intra
BCL2L2 Q92843 KASH5 Homo sapiens Q8N6L0 32296183
Intra
BCL2L2 Q92843 CD79A Homo sapiens P11912 32296183
Intra
BCL2L2 Q92843 CD79A Homo sapiens P11912 32296183
Intra
BCL2L2 Q92843 ERGIC3 Homo sapiens Q9Y282 32296183
Intra
BCL2L2 Q92843 ERGIC3 Homo sapiens Q9Y282 32296183
Intra
BCL2L2 Q92843 ERGIC3 Homo sapiens Q9Y282 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BCL2L2 Proteins

Cat. No. Product Name Accession Purity
HY-P7653 Bcl-2-like protein 2 Protein, Human (His) AAI13523.1 (A2-T172) ≥ 95%, as determined by reducing SDS-PAGE.

BCL2L2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84709 BCL2L2 Antibody (YA4406) IHC-P, ICC/IF, FC, ELISA Human
HY-P84709A BCL2L2 Antibody (YA4406)(PBS only) IHC-P, ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Blood Platelet Disease
  • Platelet Disorder

  • Blood Platelet Disorders

  • Thrombocytopathy

  • Platelet Dysfunction

  • Platelet Disorders

  • Qualitative Platelet Deficiency

B-Cell Lymphoma
  • Lymphoma, B-Cell

  • B-Cell Lymphomas

  • B-Cell Lymphocytic Neoplasm

  • Lymphoma B-Cell

  • B-Cell Lymphoma Nos

Lung Cancer
  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Protection Against

  • Lung Cancer, Susceptibility To

  • Adenocarcinoma Of Lung, Somatic

  • Nonsmall Cell Lung Cancer

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma

Hepatocellular Carcinoma
  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour

Burkitt Lymphoma
  • Burkitt'S Lymphoma

  • BL

  • Burkitt Lymphoma, Somatic

  • Burkitt Lymphoma/Leukaemia

  • Burkitt'S Tumor

  • Burkitt'S Tumor Or Lymphoma

  • Malignant Lymphoma, Burkitt'S Type

  • Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

  • Small Non-Cleaved Cell Lymphoma

  • Burkitt Tumor

  • Burkitts Lymphoma

  • Lymphoma, Small Noncleaved-Cell

  • Burkitt Tumour

  • Diffuse Small Noncleaved Malignant Burkitt Lymphoma

  • Malignant Burkitt Lymphoma

  • “Burkitt-Like” Lymphoma

  • Undifferentiated Burkitt Lymphoma

  • Small Noncleaved Cell Burkitt Lymphoma

Leukemia, Acute Myeloid
  • Acute Myeloid Leukemia

  • Leukemia, Acute Myelogenous

  • Acute Myelogenous Leukemia

  • AML

  • Leukemia, Acute Myeloid, Susceptibility To

  • Acute Myeloblastic Leukemia

  • Leukemia, Acute Myeloid, Reduced Survival In, Somatic

  • Acute Myeloid Leukaemia

  • Leukemia, Myelocytic, Acute

  • Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

  • Secondary Aml

  • Acute Myelocytic Leukemia

  • Leukemia, Myeloid, Acute

  • Acute Myeloid Leukemia, Somatic

  • Leukemia, Acute Myeloid, Somatic

  • Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

  • Acute Myeloblastic Leukaemia

  • Acute Myelogenous Leukaemia

  • Aml - Acute Myeloid Leukemia

  • Acute Myeloid Leukemia With Cebpa Somatic Mutations

  • Aml With Cebpa Somatic Mutations

  • Inherited Acute Myeloid Leukemia

  • Familial Aml

  • Inherited Aml

  • Pure Familial Aml

  • Pure Familial Acute Myeloid Leukemia

  • Secondary Acute Myeloid Leukemia

  • Therapy-Related Aml And Myelodysplastic Syndrome

  • Acute Myeloid Leukemia, Secondary

  • Acute Non-Lymphoblastic Leukemia

  • Acute Non-Lymphocytic Leukemia

  • Acute Biphenotypic Leukemia

  • Acute Undifferentiated Leukemia

  • Acute Myeloblastic Leukaemia With Multilineage Dysplasia

  • Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

  • Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Lymphoma
  • Lymphoid Cancer

  • Lymphomas

  • Lymphoid Cancers

  • Lymphoid Neoplasm

  • Lymphoma Nos

  • Nhl - [Non-Hodgkin Lymphoma]

  • Non-Hodgkin Lymphoma

  • Non-Hodgkin Lymphoma, Nos

  • Non-Hodgkin Malignant Lymphoma Nos

Leukemia, Chronic Lymphocytic
  • Chronic Lymphocytic Leukemia

  • B-Cell Chronic Lymphocytic Leukemia

  • CLL

  • B-Cell Chronic Lymphoid Leukemia

  • Chronic Lymphatic Leukemia

  • Chronic Lymphocytic Leukaemia

  • Lymphoplasmacytic Leukemia

  • Small Lymphocytic Lymphoma

  • Leukemia, Chronic Lymphatic

  • B-Cell Chronic Lymphocytic Leukaemia

  • Chronic Lymphatic Leukaemia

  • Lymphoplasmacytic Leukaemia

  • B Cell Chronic Lymphocytic Leukemia

  • Chronic B-Cell Lymphocytic Leukemia

  • Leukemia, Lymphocytic, Chronic

  • B-Cll

  • Chronic Lymphoid Leukemia

  • Leukemia Lymphocytic Chronic

  • Lymphoma Small Lymphocytic

  • Leukemia, Lymphocytic, Chronic, B-Cell

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus BCL2L2 RGD RGD:620717
Mus musculus BCL2L2 MGD MGI:108052
Bos taurus BCL2L2 VGNC VGNC:55105
Others BCL2L2 NCBI