G0S2 - G0/G1 switch 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 50486

About G0S2

Cytogenetic location: 1q32.2 Genomic coordinates (GRCh38): 1:209,675,412-209,676,390 (from NCBI)

This gene has 1 transcript (splice variant) and 163 orthologues. Biased expression in fat (RPKM 569.0), bone marrow (RPKM 395.4) and 4 other tissues.

Summary

Involved in extrinsic apoptotic signaling pathway and positive regulation of extrinsic apoptotic signaling pathway. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

G0S2 Products (1)

mRNA Protein Name
NM_015714.4 NP_056529.1 G0/G1 switch protein 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19706769 GOA
Biological Process GO Annotation Evidence References Source
involved in extrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
19706769 GOA
involved in positive regulation of extrinsic apoptotic signaling pathway IDA
IDA: Inferred from direct assay
19706769 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
19706769 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

G0S2 Protein Structure

G0-G1_switch_2

G0-G1_switch_2: G0/G1 switch protein 2 (1 - 103)

  • 0
  • 103 a.a.
Protein Preferred Names Protein Names

G0/G1 switch protein 2

  • G0/G1 switch regulatory protein 2

G0S2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
G0S2 P27469 BCL2L2 Homo sapiens Q92843
Validated Y2H
32296183
Intra
G0S2 P27469 BCL2L1 Homo sapiens Q07817
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

G0S2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811298 G0S2 Antibody WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Crohn'S Colitis

  • Crohn Disease
Hypothalamic Neoplasm

  • Hypothalamic Neoplasms

  • Neoplasm Of The Hypothalamus

  • Tumor Of Hypothalamus
Diencephalic Neoplasm

  • Malignant Diencephalic Neoplasm

  • Malignant Diencephalic Tumor

  • Tumor Of Diencephalon
Chanarin-Dorfman Syndrome

  • Neutral Lipid Storage Disease

  • CDS

  • Neutral Lipid Storage Disease With Ichthyosis

  • Triglyceride Storage Disease With Impaired Long-Chain Fatty Acid Oxidation

  • Triglyceride Storage Disease With Ichthyosis

  • Nlsdi

  • Ichthyotic Neutral Lipid Storage Disease

  • Dorfman-Chanarin Syndrome

  • Dcs

  • Chanarin-Dorfman Disease

  • Ichthyosiform Erythroderma With Leukocyte Vacuolation

  • Lipidosis With Triglyceride Storage Disease

  • Disorder Of Cornification 12

  • Dorfman Chanarin Syndrome

  • Neutral Lipid Storage Disease With Ichthyotic

  • Dorfman-Chanarin Disease
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-120897 NS-3-008 hydrochloride Inhibitor 99.67% Unkown
HY-134462 RJW103 Agonist 98.71% Unkown
HY-128453 LRH-1 antagonist-1 Antagonist / Unkown
HY-128453A LRH-1 antagonist-1 dihydrochloride Antagonist / Unkown
HY-RS05187 G0S2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18241 G0s2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24720 G0s2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus G0S2 VGNC VGNC:29174
Felis catus G0S2 VGNC VGNC:107877
Mus musculus G0S2 MGD MGI:1316737
Macaca mulatta G0S2 VGNC VGNC:99957
Rattus norvegicus G0S2 RGD RGD:1311675
Others G0S2 NCBI