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Art. -Nr.: HY-N20627

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Withametelin B

Withametelin B is a hexacyclic withanolide that can be isolated from Datura metel leaves. Withametelin B can bind to Bcl-2.

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CAS. Nr.: 123523-09-1
Formel: C₂₈H₃₆O₅
Molecular Weight:452.58

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Withametelin B Chemical Structure

CAS. Nr.: 123523-09-1

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Biologische Aktivität
- Beschreibung
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Withametelin B is a hexacyclic withanolide that can be isolated from Datura metel leaves. Withametelin B can bind to Bcl-2^[1]^[2].

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen :

In Vitro

Withametelin B binds to purified Bcl-2 (PDB ID 6O0K) with a binding affinity of -8.8 kcal/mol, interacting with key functional residues of the protein's BH1 domain^[1].
Withametelin B binds to Bcl-2 with a favorable binding free energy of -32.22 kJ/mol, confirming a strong stable interaction^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 123523-09-1
Molecular Weight 452.58
Formel C₂₈H₃₆O₅
SMILES

C[C@@]12[C@](CC[C@]2([H])[C@@]3([H])[C@@]4([H])C[C@@](OC3)(C(C(O4)=O)=C)C)([H])[C@@]5([H])[C@@](CC1)([H])[C@@]6(C([C@@H](C5)O)=CC=CC6=O)C
Structure Classification
- Others
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Alkhathami AG, et al. Phytochemicals Daturilinol and Withametelin B identified as novel Bcl2 inhibitors via virtual screening and molecular simulations. Sci Rep. 2025;15(1):33029. Published 2025 Sep 26. [Content Brief]

[2]. Mohini Gupta, et al. Additional Withanolides of Datura metel. J. Nat. Prod. 1991, 54, 2, 599-602.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biologische Aktivität
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- In Vitro
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Withametelin B

Alle Bcl-2 Family Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Withametelin B Related Classifications

HY-N20627 Related Classifications