ABT-737-d8
Based on 1 Customer Validation
ABT 737-d8 is the deuterium labeled ABT-737. ABT-737, a BH3 mimetic, is a potent Bcl-2, Bcl-xL and Bcl-w inhibitor with EC50s of 30.3 nM, 78.7 nM, and 197.8 nM, respectively. ABT-737 induces the disruption of the BCL-2/BAX complex and BAK-dependent but BIM-independent activation of the intrinsic apoptotic pathway. ABT-737 induces autophagy and has the potential for acute myeloid leukemia (AML) research.
For research use only. We do not sell to patients.
- Purity: 99.11%
- CAS No.: 1217686-68-4
- Formula: C42H37D8ClN6O5S2
- Molecular Weight:821.48
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 1217686-68-4
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Unlabeled Cas 852808-04-9
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Appearance Solid
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Molecular Weight 821.48
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Formula C42H37D8ClN6O5S2
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Color Light yellow to yellow
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SMILES
ClC(C=C1)=CC=C1C(C=CC=C2)=C2CN3C([2H])([2H])C([2H])([2H])N(C4=CC=C(C=C4)C(NS(=O)(C5=CC([N+]([O-])=O)=C(C=C5)N[C@H](CCN(C)C)CSC6=CC=CC=C6)=O)=O)C([2H])([2H])C3([2H])[2H]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (60.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Konopleva M, et al. Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. Cancer Cell. 2006 Nov;10(5):375-88. [Content Brief]
[3]. Ahamed Saleem, et al. Effect of dual inhibition of apoptosis and autophagy in prostate cancer. Prostate. 2012 Sep 1;72(12):1374-81. [Content Brief]
[4]. Clerc P, et al. Polster BM.Rapid Detection of an ABT-737-Sensitive Primed for Death State in Cells Using Microplate-Based Respirometry.PLoS One. 2012;7(8):e42487. Epub 2012 Aug 3. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2173 mL | 6.0866 mL | 12.1732 mL | 30.4329 mL |
| 5 mM | 0.2435 mL | 1.2173 mL | 2.4346 mL | 6.0866 mL | |
| 10 mM | 0.1217 mL | 0.6087 mL | 1.2173 mL | 3.0433 mL | |
| 15 mM | 0.0812 mL | 0.4058 mL | 0.8115 mL | 2.0289 mL | |
| 20 mM | 0.0609 mL | 0.3043 mL | 0.6087 mL | 1.5216 mL | |
| 25 mM | 0.0487 mL | 0.2435 mL | 0.4869 mL | 1.2173 mL | |
| 30 mM | 0.0406 mL | 0.2029 mL | 0.4058 mL | 1.0144 mL | |
| 40 mM | 0.0304 mL | 0.1522 mL | 0.3043 mL | 0.7608 mL | |
| 50 mM | 0.0243 mL | 0.1217 mL | 0.2435 mL | 0.6087 mL | |
| 60 mM | 0.0203 mL | 0.1014 mL | 0.2029 mL | 0.5072 mL |
ABT-737-d8 Related Classifications
HY-50907S Related Classifications
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