1. Apoptosis
    NF-κB
  2. Bcl-2 Family
    Apoptosis
    NF-κB
  3. 2-Hydroxychalcone

2-Hydroxychalcone 

Cat. No.: HY-119931
Handling Instructions

2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB.

For research use only. We do not sell to patients.

2-Hydroxychalcone Chemical Structure

2-Hydroxychalcone Chemical Structure

CAS No. : 644-78-0

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Description

2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB[1][2][3].

In Vitro

2-Hydroxychalcone inhibits invasion of triple negative breast cancer cells[1].
2-hydroxychalcone inhibits the adhesion of peripheral neutrophils to the endothelial cell monolayers by inhibiting the expression of ICAM-1, VCAM-1, and E-selectin in a concentration-dependent manner[2].

Molecular Weight

224.25

Formula

C₁₅H₁₂O₂

CAS No.

644-78-0

SMILES

O=C(C1=CC=CC=C1)/C=C/C2=CC=CC=C2O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

2-HydroxychalconeBcl-2 FamilyApoptosisNF-κBNuclear factor-κBNuclear factor-kappaBTNBCInhibitorinhibitorinhibit

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2-Hydroxychalcone
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HY-119931
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