2. Apoptosis NF-κB Anti-infection
  3. Bcl-2 Family Apoptosis NF-κB Parasite
  4. 2-Hydroxychalcone

2-Hydroxychalcone 

Cat. No.: HY-119931 Purity: 98.80%
COA Handling Instructions

2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB.

For research use only. We do not sell to patients.

2-Hydroxychalcone Chemical Structure

2-Hydroxychalcone Chemical Structure

CAS No. : 644-78-0

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Solid + Solvent
10 mM * 1 mL in DMSO
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 USD 55 In-stock
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10 mM * 1 mL in DMSO USD 55 In-stock
Solid
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100 mg USD 80 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

2-Hydroxychalcone Related Antibodies

Top Publications Citing Use of Products

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB[1][2][3].

In Vitro

2-Hydroxychalcone inhibits invasion of triple negative breast cancer cells[1].
2-hydroxychalcone inhibits the adhesion of peripheral neutrophils to the endothelial cell monolayers by inhibiting the expression of ICAM-1, VCAM-1, and E-selectin in a concentration-dependent manner[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2-Hydroxychalcone Related Antibodies
Molecular Weight

224.25

Appearance

Solid

Formula

C15H12O2
CAS No.
SMILES

O=C(C1=CC=CC=C1)/C=C/C2=CC=CC=C2O
Structure Classification
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (557.41 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4593 mL 22.2965 mL 44.5931 mL
5 mM 0.8919 mL 4.4593 mL 8.9186 mL
10 mM 0.4459 mL 2.2297 mL 4.4593 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (9.28 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (9.28 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References
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2-Hydroxychalcone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

2-Hydroxychalcone644-78-0Bcl-2 FamilyApoptosisNF-κBParasiteNuclear factor-κBNuclear factor-kappaBTNBCInhibitorinhibitorinhibit

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