644-78-0
644-78-0
Chemical Structure
2-Hydroxychalcone
- CAS 番号: 644-78-0
- Formula:C15H12O2
- Molecular Weight:224.25
IUPAC Name: (E)-3-(2-hydroxyphenyl)-1-phenylprop-2-en-1-one
InChIKey: UDOOPSJCRMKSGL-ZHACJKMWSA-N
SMILES: O=C(C1=CC=CC=C1)/C=C/C2=CC=CC=C2O
Biological Activity: 2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB[1][2][3].
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2-Hydroxychalcone | 98.54% | 2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.84
HY-W1542652,2′-Dihydroxychalcone -
Similarity Score 0.83
HY-W0123492′-Hydroxychalcone -
Similarity Score 0.82
HY-121054RChalcone (Standard) -
Similarity Score 0.82
HY-Y0598trans-Chalcone -
Similarity Score 0.82
HY-107818R4-Hydroxychalcone (Standard) -
Similarity Score 0.80
HY-N7056R4'-Hydroxychalcone (Standard) -
Similarity Score 0.79
HY-145104Antioxidant agent-1 -
Similarity Score 0.78
HY-W3251604-Chlorochalcone -
Similarity Score 0.78
HY-1284522'-Hydroxy-2-methoxychalcone -
Explore the MedChemAI to find more analogs
References
- [1]. Sun Young Kim, et al. 2-Hydroxychalcone and Xanthohumol Inhibit Invasion of Triple Negative Breast Cancer Cells. Chem Biol Interact. 2013 May 25;203(3):565-72. [Content Brief]
- [2]. B Madan, et al. 2'-hydroxychalcone Inhibits Nuclear factor-kappaB and Blocks Tumor Necrosis Factor-Alpha- And Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol. 2000 Sep;58(3):526-34. [Content Brief]
- [3]. BABITA MADAN, et al. 2-Hydroxychalcone Inhibits Nuclear Factor-kB and Blocks Tumor Necrosis Factor-a- and Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol 58:526–534, 2000. [Content Brief]
