2. Metabolic Enzyme/Protease Apoptosis
  3. Glutathione S-transferase Apoptosis
  4. 2,2′-Dihydroxychalcone

2,2′-Dihydroxychalcone, a flavonoid, is a glutathione S-transferase (GST) inhibitor with an IC50 of 28.9 μM in human colon cancer cells. 2,2′-Dihydroxychalcone induces cell cycle arrest and apoptosis in prostate cancer cells. 2,2′-Dihydroxychalcone has anticancer and anti-inflammatory properties.

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2,2′-Dihydroxychalcone Chemical Structure

2,2′-Dihydroxychalcone Chemical Structure

CAS No. : 15131-80-3

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2,2′-Dihydroxychalcone Related Antibodies

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Description

2,2′-Dihydroxychalcone, a flavonoid, is a glutathione S-transferase (GST) inhibitor with an IC50 of 28.9 μM in human colon cancer cells. 2,2′-Dihydroxychalcone induces cell cycle arrest and apoptosis in prostate cancer cells. 2,2′-Dihydroxychalcone has anticancer and anti-inflammatory properties[1][2].

In Vitro

2,2′-Dihydroxychalcone (1-50 μM; 72 h) causes a dose-dependent reduction in viability, a concomitant increase in apoptosis in PC3 cells at 72 h, and a decrease in clonogenic survival at 24 h treatment[1].
2,2′-Dihydroxychalcone (15 μM; 6-48 h) markedly decreases the protein levels of Cyclin A and Cyclin B1, cdc2 and PIK1[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2,2′-Dihydroxychalcone Related Antibodies

Cell Viability Assay[1]

Cell Line: PC3 cells
Concentration: 1 μM, 5 μM, 15 μM, 25 μM, 50 μM
Incubation Time: 72 h
Result: Decreaseed PC3 cell viability and inhibited clonogenic survival.

Apoptosis Analysis[1]

Cell Line: PC3 cells
Concentration: 1 μM, 5 μM, 15 μM, 25 μM, 50 μM
Incubation Time: 72 h
Result: Induced apoptosis in PC3 cells.

Western Blot Analysis[1]

Cell Line: PC3 cells
Concentration: 15 μM
Incubation Time: 6 h, 12 h, 24 h, 48 h
Result: Induced cell cycle arrest in PC3 cells.
Molecular Weight

240.25

Formula

C15H12O3
CAS No.
Unlabeled CAS

SMILES

O=C(C1=CC=CC=C1O)C=CC2=CC=CC=C2O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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2,2′-Dihydroxychalcone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2,2′-Dihydroxychalcone15131-80-3Glutathione S-transferaseApoptosisGlutathione transferasesGSTsapoptosis inducercell cycle arrestanticancer and anti-inflammatory propertiesflavonoidGSTInhibitorinhibitorinhibit

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