15131-80-3
15131-80-3
Chemical Structure
2,2′-Dihydroxychalcone
- CAS No.: 15131-80-3
- Formula:C15H12O3
- Molecular Weight:240.25
IUPAC Name: (E)-1,3-bis(2-hydroxyphenyl)prop-2-en-1-one
InChIKey: KSHCTKZLHCSARH-MDZDMXLPSA-N
SMILES: O=C(C1=CC=CC=C1O)C=CC2=CC=CC=C2O
Biological Activity: 2,2′-Dihydroxychalcone, a flavonoid, is a glutathione S-transferase (GST) inhibitor with an IC50 of 28.9 μM in human colon cancer cells. 2,2′-Dihydroxychalcone induces cell cycle arrest and apoptosis in prostate cancer cells. 2,2′-Dihydroxychalcone has anticancer and anti-inflammatory properties[1][2].
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2,2′-Dihydroxychalcone | 2,2′-Dihydroxychalcone, a flavonoid, is a glutathione S-transferase (GST) inhibitor with an IC50 of 28.9 μM in human colon cancer cells. 2,2′-Dihydroxychalcone induces cell cycle arrest and apoptosis in prostate cancer cells. 2,2′-Dihydroxychalcone has anticancer and anti-inflammatory properties. | |||||||||||||||||||||
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References
- [1]. Ahmed Q Haddad, et al. Antiproliferative mechanisms of the flavonoids 2,2'-dihydroxychalcone and fisetin in human prostate cancer cells. Nutr Cancer. 2010;62(5):668-81. [Content Brief]
- [2]. Kenneth Goh, et al. 2,2'-Dihydroxychalcone, a glutathione transferase inhibitor, sensitises human colon adenocarcinoma cells to chlorambucil and melphalan, but not to actinomycin D. Mol Med Rep. 2008 Jul-Aug;1(4):575-9. [Content Brief]
Keywords
