Apoptotic agent-3 

Apoptotic agent-3 (compound 15f) promotes apoptosis through the potential mitochondria-mediated Bcl-2/Bax pathway and activation of the Caspase 3 pathway. Apoptotic agent-3 exhibits anti-proliferative activities and can be used for cancer research^[1].

Apoptotic agent-3 (compound 15f) (24 hours) has selective anti-proliferative activities against HCT-116, HepG-2 MCF-7 and WI-38 cells (normal human cells) with IC₅₀ values of 1.62, 1.46, 2.04 and 117.9 µM, respectively^[1].
. Apoptotic agent-3 (compound 15f) (24 hours) (1.46 μM; 24 hours; HepG-2 cells) induces cell apoptosis, which increases the levels of active Caspase-3 and BAX by 11.53 folds and 10 folds, respectively, and decreases the level of Bcl-2 by 3.8 folds^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

511.60

C₃₁H₂₁N₅OS

2482310-23-4

COC1=CC=C(C2=CS/C(N2C3=CC=CC=C3)=N/N=C4C5=C(C6=NC7=CC=CC=C7N=C6\4)C=CC=C5)C=C1

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• [1]. Fayed EA, et al. In vitro cytotoxic activity of thiazole-indenoquinoxaline hybrids as apoptotic agents, design, synthesis, physicochemical and pharmacokinetic studies. Bioorg Chem. 2020 Jul;100:103951.  [Content Brief]