1. Apoptosis
  2. Bcl-2 Family
  3. Bcl-2-IN-2

Bcl-2-IN-2 

Cat. No.: HY-131247
Handling Instructions

Bcl-2-IN-2 is a potent and selective Bcl-2 inhibitor with an IC50 of 0.034 nM and also inhibits Bcl-xL with an IC50 of 43 nM, showing >1000-fold selectivity for Bcl-2 over Bcl-xL.

For research use only. We do not sell to patients.

Bcl-2-IN-2 Chemical Structure

Bcl-2-IN-2 Chemical Structure

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Description

Bcl-2-IN-2 is a potent and selective Bcl-2 inhibitor with an IC50 of 0.034 nM and also inhibits Bcl-xL with an IC50 of 43 nM, showing >1000-fold selectivity for Bcl-2 over Bcl-xL[1].

IC50 & Target[1]

Bcl-2

0.034 nM (IC50)

Bcl-xL

43 nM (IC50)

In Vitro

Bcl-2-IN-2 inhibits mutant Bcl-2-G101V with an IC50 of 1.2 nM. Bcl-2-IN-2 inhibits RS4;11 cellular proliferation with an IC50 of 1.9 nM[1].

Molecular Weight

876.07

Formula

C₄₈H₅₇N₇O₇S

SMILES

O=C(NS(=O)(C1=CC=C(NC[[email protected]]2CC[[email protected]@](O)(C)CC2)C([N+]([O-])=O)=C1)=O)C3=CC=C(N4CCC5(CC(N6CCC[[email protected]]6C7=C(CC)C=CC=C7)C5)CC4)C=C3OC8=CC(C=CN9)=C9N=C8

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Bcl-2-IN-2Bcl-2 FamilyCancerautoimmuneBcl-2Bcl-xLInhibitorinhibitorinhibit

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Bcl-2-IN-2
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