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Cat. No.: HY-12011A

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(Rac)-HA14-1

(Rac)-HA14-1 is the racemic form of HA14-1 (HY-12011). HA14-1 is a Bcl-2/Bcl-x_L antagonist with an IC₅₀ of approximately 9 μM against Bcl-2.

For research use only. We do not sell to patients.

CAS No.: 927635-64-1
Formula: C₁₇H₁₇BrN₂O₅
Molecular Weight:409.23

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

(Rac)-HA14-1 Chemical Structure

CAS No.: 927635-64-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

(Rac)-HA14-1 is the racemic form of HA14-1 (HY-12011). HA14-1 is a Bcl-2/Bcl-x_L antagonist with an IC₅₀ of approximately 9 μM against Bcl-2^[1].

All Bcl-2 Family Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
RPMI-8226	IC₅₀	12600 nM Compound: 11; HA 14-1	Cytotoxicity against human RPMI-8226 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay Cytotoxicity against human RPMI-8226 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay	[PMID: 37690265]

Chemical Information

CAS No. 927635-64-1
Molecular Weight 409.23
Formula C₁₇H₁₇BrN₂O₅
SMILES

N#CC(C1C2=CC(Br)=CC=C2OC(N)=C1C(OCC)=O)C(OCC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Azmi AS, et al. Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy. J Cell Physiol. 2009 Jan;218(1):13-21. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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(Rac)-HA14-1

All Bcl-2 Family Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

(Rac)-HA14-1 Related Classifications

HY-12011A Related Classifications