1. Apoptosis
  2. Bcl-2 Family
  3. TCPOBOP

TCPOBOP 

Cat. No.: HY-103243
Handling Instructions

TCPOBOP is a constitutive androstane receptor (CAR) agonist that induces robust hepatocyte proliferation and hepatomegaly without any liver injury or tissue loss. TCPOBOP attenuates Fas-induced murine liver injury by altering Bcl-2 proteins.

For research use only. We do not sell to patients.

TCPOBOP Chemical Structure

TCPOBOP Chemical Structure

CAS No. : 76150-91-9

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Description

TCPOBOP is a constitutive androstane receptor (CAR) agonist that induces robust hepatocyte proliferation and hepatomegaly without any liver injury or tissue loss[1]. TCPOBOP attenuates Fas-induced murine liver injury by altering Bcl-2 proteins[2].

IC50 & Target[2]

Bcl-2

 

In Vivo

TCPOBOP (oral; 3 mg/kg; 1-5 days) remarkable increases Liver weight to body weight in LW/BW ratio at 48 hours[1].

Animal Model: METfl/fl: Tam-Cre+/+ mice with a targeted deletion for exon 16 with MET KO[1]
Dosage: 3 mg/kg
Administration: Oral; 1, 2, 5 days
Result: Increased Liver weight to body weight.
Molecular Weight

402.06

Formula

C₁₆H₈Cl₄N₂O₂

CAS No.

76150-91-9

SMILES

ClC1=CN=C(OC2=CC=C(OC3=NC=C(Cl)C=C3Cl)C=C2)C(Cl)=C1

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Room temperature in continental US; may vary elsewhere

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Please store the product under the recommended conditions in the Certificate of Analysis.

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TCPOBOP
Cat. No.:
HY-103243
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