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  3. TCPOBOP

TCPOBOP 

Cat. No.: HY-103243
Handling Instructions

TCPOBOP is a constitutive androstane receptor (CAR) agonist that induces robust hepatocyte proliferation and hepatomegaly without any liver injury or tissue loss. TCPOBOP attenuates Fas-induced murine liver injury by altering Bcl-2 proteins.

For research use only. We do not sell to patients.

TCPOBOP Chemical Structure

TCPOBOP Chemical Structure

CAS No. : 76150-91-9

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
5 mg USD 50 In-stock
Estimated Time of Arrival: December 31
10 mg USD 80 In-stock
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25 mg USD 150 In-stock
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50 mg USD 250 In-stock
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100 mg USD 400 In-stock
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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE TCPOBOP

    TCPOBOP purchased from MCE. Usage Cited in: Pharmacol Res. 2020 Nov;161:105110.

    Treatment with TCPOBOP enhances the expression of ABCB1 in AC PDCs from PDCs No. 4 and 5 (expressing high levels of endogenous CAR).

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    Description

    TCPOBOP is a constitutive androstane receptor (CAR) agonist that induces robust hepatocyte proliferation and hepatomegaly without any liver injury or tissue loss[1]. TCPOBOP attenuates Fas-induced murine liver injury by altering Bcl-2 proteins[2].

    IC50 & Target[2]

    Bcl-2

     

    In Vivo

    TCPOBOP (oral; 3 mg/kg; 1-5 days) remarkable increases Liver weight to body weight in LW/BW ratio at 48 hours[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: METfl/fl: Tam-Cre+/+ mice with a targeted deletion for exon 16 with MET KO[1]
    Dosage: 3 mg/kg
    Administration: Oral; 1, 2, 5 days
    Result: Increased Liver weight to body weight.
    Molecular Weight

    402.06

    Formula

    C₁₆H₈Cl₄N₂O₂

    CAS No.

    76150-91-9

    SMILES

    ClC1=CN=C(OC2=CC=C(OC3=NC=C(Cl)C=C3Cl)C=C2)C(Cl)=C1

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    Solvent & Solubility
    In Vitro: 

    DMSO : 25 mg/mL (62.18 mM; ultrasonic and warming and heat to 50°C)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.4872 mL 12.4360 mL 24.8719 mL
    5 mM 0.4974 mL 2.4872 mL 4.9744 mL
    10 mM 0.2487 mL 1.2436 mL 2.4872 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: 2.5 mg/mL (6.22 mM); Suspended solution; Need ultrasonic

    • 2.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (6.22 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    Keywords:

    TCPOBOPBcl-2 FamilyInhibitorinhibitorinhibit

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    Product Name:
    TCPOBOP
    Cat. No.:
    HY-103243
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