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  3. TCPOBOP

TCPOBOP 

Cat. No.: HY-103243
Handling Instructions

TCPOBOP is a constitutive androstane receptor (CAR) agonist that induces robust hepatocyte proliferation and hepatomegaly without any liver injury or tissue loss. TCPOBOP attenuates Fas-induced murine liver injury by altering Bcl-2 proteins.

For research use only. We do not sell to patients.

TCPOBOP Chemical Structure

TCPOBOP Chemical Structure

CAS No. : 76150-91-9

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Top Publications Citing Use of Products

Publications Citing Use of MCE TCPOBOP

    TCPOBOP purchased from MCE. Usage Cited in: Pharmacol Res. 2020 Aug 2;105110.

    Treatment with TCPOBOP enhances the expression of ABCB1 in AC PDCs from PDCs No. 4 and 5 (expressing high levels of endogenous CAR).

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    Description

    TCPOBOP is a constitutive androstane receptor (CAR) agonist that induces robust hepatocyte proliferation and hepatomegaly without any liver injury or tissue loss[1]. TCPOBOP attenuates Fas-induced murine liver injury by altering Bcl-2 proteins[2].

    IC50 & Target[2]

    Bcl-2

     

    In Vivo

    TCPOBOP (oral; 3 mg/kg; 1-5 days) remarkable increases Liver weight to body weight in LW/BW ratio at 48 hours[1].

    Animal Model: METfl/fl: Tam-Cre+/+ mice with a targeted deletion for exon 16 with MET KO[1]
    Dosage: 3 mg/kg
    Administration: Oral; 1, 2, 5 days
    Result: Increased Liver weight to body weight.
    Molecular Weight

    402.06

    Formula

    C₁₆H₈Cl₄N₂O₂

    CAS No.

    76150-91-9

    SMILES

    ClC1=CN=C(OC2=CC=C(OC3=NC=C(Cl)C=C3Cl)C=C2)C(Cl)=C1

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.

    References
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    Keywords:

    TCPOBOPBcl-2 FamilyInhibitorinhibitorinhibit

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