76150-91-9
76150-91-9
Chemical Structure
TCPOBOP
- CAS No.: 76150-91-9
- Formula:C16H8Cl4N2O2
- Molecular Weight:402.06
IUPAC Name: 1,4-bis((3,5-dichloropyridin-2-yl)oxy)benzene
InChIKey: BAFKRPOFIYPKBQ-UHFFFAOYSA-N
SMILES: ClC1=CN=C(OC2=CC=C(OC3=NC=C(Cl)C=C3Cl)C=C2)C(Cl)=C1
Biological Activity: TCPOBOP is a constitutive androstane receptor (CAR) agonist that induces robust hepatocyte proliferation and hepatomegaly without any liver injury or tissue loss[1]. TCPOBOP attenuates Fas-induced murine liver injury by altering Bcl-2 proteins[2].
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TCPOBOP | 99.70% | TCPOBOP is a constitutive androstane receptor (CAR) agonist that induces robust hepatocyte proliferation and hepatomegaly without any liver injury or tissue loss. TCPOBOP attenuates Fas-induced murine liver injury by altering Bcl-2 proteins. | ||||||||||||||||||||
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TCPOBOP (Standard) | ≥98% | TCPOBOP (Standard) is the analytical standard of TCPOBOP. This product is intended for research and analytical applications. TCPOBOP is a constitutive androstane receptor (CAR) agonist that induces robust hepatocyte proliferation and hepatomegaly without any liver injury or tissue loss. TCPOBOP attenuates Fas-induced murine liver injury by altering Bcl-2 proteins. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.62
HY-184803PCDE 37 -
Similarity Score 0.61
HY-117142Quizalofop-P -
Similarity Score 0.61
HY-123307Quizalofop -
Similarity Score 0.61
HY-120679XK469 -
Similarity Score 0.61
HY-120734Quinoxyfen -
Similarity Score 0.60
HY-110190VU0422288 -
Similarity Score 0.59
HY-1606448PC -
Similarity Score 0.59
HY-B1119Triclosan -
Similarity Score 0.59
HY-W653962Triclosan-13C6 -
Explore the MedChemAI to find more analogs
References
- [1]. Bhushan B, et al. TCPOBOP-Induced Hepatomegaly and Hepatocyte Proliferation are Attenuated by Combined Disruption of MET and EGFR Signaling. Hepatology. 2019 Apr;69(4):1702-1718. [Content Brief]
- [2]. Baskin-Bey ES, et al. Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins. Hepatology. 2006 Jul;44(1):252-62. [Content Brief]
