BCL2/BAX modulator-1
BCL2/BAX modulator-1 is an orally active BCL2/BAX modulator and apoptosis inducer. BCL2/BAX modulator-1 downregulates BCL2 mRNA expression, upregulates BAX mRNA expression, and occupies the BAX trigger site. BCL2/BAX modulator-1 can be used for research on prostate adenocarcinoma, hepatocellular carcinoma, and lung adenocarcinoma.
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- CAS No.: 1416344-06-3
- Formule: C18H18N2O2
- Masse moléculaire:294.35
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| LNCaP | IC50 |
11.84 μM
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Cytotoxic activity against human prostate adenocarcinoma LNCaP cells assessed as reduction in cell viability incubated for 48 hrs by WST-1 colorimetric assay.
Cytotoxic activity against human prostate adenocarcinoma LNCaP cells assessed as reduction in cell viability incubated for 48 hrs by WST-1 colorimetric assay.
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42556024 |
| HepG2 | IC50 |
19.59 μM
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Cytotoxic activity against human hepatocellular carcinoma HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by WST-1 colorimetric assay.
Cytotoxic activity against human hepatocellular carcinoma HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by WST-1 colorimetric assay.
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42556024 |
| A549 | IC50 |
20.22 μM
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Cytotoxic activity against human lung adenocarcinoma A549 cells assessed as reduction in cell viability incubated for 48 hrs by WST-1 colorimetric assay.
Cytotoxic activity against human lung adenocarcinoma A549 cells assessed as reduction in cell viability incubated for 48 hrs by WST-1 colorimetric assay.
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42556024 |
| HEK-293T | IC50 |
65.28 μM
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Cytotoxic activity against non-cancerous human embryonic kidney 293T cells assessed as reduction in cell viability incubated for 48 hrs by WST-1 colorimetric assay.
Cytotoxic activity against non-cancerous human embryonic kidney 293T cells assessed as reduction in cell viability incubated for 48 hrs by WST-1 colorimetric assay.
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42556024 |
In Vitro
BCL2/BAX modulator-1 demonstrates a pro-apoptotic effect in A549 cells by significantly up-regulating BAX mRNA expression and down-regulating BCL2 mRNA expression[1].
BCL2/BAX modulator-1 is predicted to bind to the BAX trigger site, forming a hydrogen bond with Gln32, which may contribute to its pro-apoptotic activity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LNCaP, HepG2, A549, 293T
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Concentration:0, 5, 12.5, 37.5, 45, 65, 87.5, 100 μM
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Incubation Time:48 h
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Result:Showed pronounced cytotoxic activity against LNCaP cells with an IC50 of 11.84 μM.
Exhibited an IC50 of 19.59 μM against HepG2 cells.
Exhibited an IC50 of 20.22 μM against A549 cells.
Exhibited an IC50 of 65.28 μM against non-cancerous 293T cells.
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Cell Line:A549
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Concentration:IC50 concentration
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Incubation Time:24 h
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Result:Up-regulated pro-apoptotic BAX mRNA expression to a fold change of 1.875.
Down-regulated anti-apoptotic BCL2 mRNA expression to a fold change of 0.401.
Chemical Information
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CAS No. 1416344-06-3
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Masse moléculaire 294.35
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Formule C18H18N2O2
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SMILES
CC(C)C(C=C1)=CC=C1C2=NC3=CC(C(OC)=O)=CC=C3N2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BCL2/BAX modulator-1 Related Classifications
HY-189216 Related Classifications
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