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製品番号: HY-189216

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BCL2/BAX modulator-1

BCL2/BAX modulator-1 is an orally active BCL2/BAX modulator and apoptosis inducer. BCL2/BAX modulator-1 downregulates BCL2 mRNA expression, upregulates BAX mRNA expression, and occupies the BAX trigger site. BCL2/BAX modulator-1 can be used for research on prostate adenocarcinoma, hepatocellular carcinoma, and lung adenocarcinoma.

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CAS 番号: 1416344-06-3
分子式: C₁₈H₁₈N₂O₂
分子量:294.35

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

BCL2/BAX modulator-1 構造式

CAS 番号: 1416344-06-3

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Bcl-2 Family アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
LNCaP	IC50	11.84 μM	Cytotoxic activity against human prostate adenocarcinoma LNCaP cells assessed as reduction in cell viability incubated for 48 hrs by WST-1 colorimetric assay. Cytotoxic activity against human prostate adenocarcinoma LNCaP cells assessed as reduction in cell viability incubated for 48 hrs by WST-1 colorimetric assay.	42556024
HepG2	IC50	19.59 μM	Cytotoxic activity against human hepatocellular carcinoma HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by WST-1 colorimetric assay. Cytotoxic activity against human hepatocellular carcinoma HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by WST-1 colorimetric assay.	42556024
A549	IC50	20.22 μM	Cytotoxic activity against human lung adenocarcinoma A549 cells assessed as reduction in cell viability incubated for 48 hrs by WST-1 colorimetric assay. Cytotoxic activity against human lung adenocarcinoma A549 cells assessed as reduction in cell viability incubated for 48 hrs by WST-1 colorimetric assay.	42556024
HEK-293T	IC50	65.28 μM	Cytotoxic activity against non-cancerous human embryonic kidney 293T cells assessed as reduction in cell viability incubated for 48 hrs by WST-1 colorimetric assay. Cytotoxic activity against non-cancerous human embryonic kidney 293T cells assessed as reduction in cell viability incubated for 48 hrs by WST-1 colorimetric assay.	42556024

体外実験

Apoptosis

BCL2/BAX modulator-1 (2h) (0-100 μM; 48 h) exhibits potent cytotoxic activity against LNCaP, HepG2, and A549 cancer cell lines, with the highest potency observed in LNCaP cells (IC₅₀=11.84 μM), while showing lower cytotoxicity toward non-cancerous 293T cells^[1].
BCL2/BAX modulator-1 demonstrates a pro-apoptotic effect in A549 cells by significantly up-regulating BAX mRNA expression and down-regulating BCL2 mRNA expression^[1].
BCL2/BAX modulator-1 is predicted to bind to the BAX trigger site, forming a hydrogen bond with Gln32, which may contribute to its pro-apoptotic activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

LNCaP, HepG2, A549, 293T
Concentration:

0, 5, 12.5, 37.5, 45, 65, 87.5, 100 μM
Incubation Time:

48 h
Result:

Showed pronounced cytotoxic activity against LNCaP cells with an IC50 of 11.84 μM.
Exhibited an IC50 of 19.59 μM against HepG2 cells.
Exhibited an IC50 of 20.22 μM against A549 cells.
Exhibited an IC50 of 65.28 μM against non-cancerous 293T cells.

Real Time qPCR^[1]

Cell Line:

A549
Concentration:

IC50 concentration
Incubation Time:

24 h
Result:

Up-regulated pro-apoptotic BAX mRNA expression to a fold change of 1.875.
Down-regulated anti-apoptotic BCL2 mRNA expression to a fold change of 0.401.

Related Protocols :

化学情報

CAS 番号 1416344-06-3
分子量 294.35
分子式 C₁₈H₁₈N₂O₂
SMILES

CC(C)C(C=C1)=CC=C1C2=NC3=CC(C(OC)=O)=CC=C3N2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (276 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Cakmak GY, et al. Some novel benzimidazole and benzoxazole methyl ester derivatives as BCL2 inhibitors and BAX activators: Synthesis, anticancer activity and in silico evaluation. European journal of medicinal chemistry. 2026 Nov 15;318:119204.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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