HDAC6-IN-67

HDAC6-IN-67 shows significant time-dependent inhibition of tumor cells in all tested human cancer cell lines, with GI₅₀ values ranging from 2.9 to 24.8 μM, it also shows strong anti-proliferative activity against MCF-7/ADR cells after 72 hours (GI₅₀ = 2.4 μM)^[1].
HDAC6-IN-67 (0.01-2 μM, 24 hours) can dose-dependently increase the acetylation of α-tubulin in MCF-7/ADR cells without affecting the acetylation of histone H3 even at high concentrations ^[1].
HDAC6-IN-67 (0.1-2 μM, 10 days) results in a significant dose-dependent inhibition of colony formation in MCF-7/ADR cells^[1].
HDAC6-IN-67 (0.1-2 μM, 24 h) significantly induces early and late apoptosis, and further confirms its apoptotic effect, demonstrating a dose-dependent induction of cleavage of Caspase 9, Caspase 8, Caspase 3, and PARP, along with significant upregulation of the pro-apoptotic protein Bax and downregulation of the anti-apoptotic protein Bcl-2 in MCF-7/ADR cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.