EMT inhibitor-3
EMT inhibitor-3 (compound 11i) is a epithelial-mesenchymal transition (EMT) inhibitor. EMT inhibitor-3 inhibits neuroblastoma SK-N-SH cells with an IC50 of 2.5 μM. EMT inhibitor-3 inhibits SK-N-SH cell proliferation, migration, and invasion. EMT inhibitor-3 increases the Bax/Bcl-2 protein expression ratio, promotes Cytochrome C ( HY-125857) release from mitochondria, and activates caspases 9 and caspases 3, inducing mitochondria-mediated endogenous tumor cell Apoptosis. EMT inhibitor-3 is potential for cancer research.
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- No. CAS: 2930726-89-7
- Fòrmula: C29H21F2N3O4Se
- Peso molecular:592.45
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
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Bax |
Bcl-2 |
Caspase 3 |
Caspase 9 |
Chemical Information
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No. CAS 2930726-89-7
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Peso molecular 592.45
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Fòrmula C29H21F2N3O4Se
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SMILES
O=C1C(C(N2N=C(C3=CC=C(F)C=C3)CC2C4=CC=C(F)C=C4)=O)=CC5=C(O1)C=C(OCCC[Se]C#N)C=C5
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EMT inhibitor-3 Related Classifications
HY-170929 Related Classifications
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