Bcl-2-IN-5
Bcl-2-IN-5 is a BCL-2 inhibitor with IC50s of 0.12 nM, 0.14 nM and 0.22 nM for Bcl-2 wild type, Bcl-2 D103Y and Bcl-2 G101V, respectively. Bcl-2-IN-5 inhibits the cell growth with IC50 values of 0.2 nM and 0.44 nM for Bcl 2-G101V knock-in RS4; 11 and RS4; 11 cells, respectively (WO2021208963A1; Example 155).
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- CAS No.: 2728752-20-1
- Formule: C55H63FN8O8S
- Masse moléculaire:1015.20
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
Bcl-2 0.12 nM (IC50) |
Bcl-2 D103Y 0.14 nM (IC50) |
Bcl-2 G101V 0.22 nM (IC50) |
Chemical Information
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CAS No. 2728752-20-1
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Masse moléculaire 1015.20
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Formule C55H63FN8O8S
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SMILES
COC(C=C1)=CC=C1CN(CC2)C[C@](C3=C(C=CC=C3)C(C)C)([H])N2C(C4)CC4(C5)CN5C6=CC(OC7=CN=C(NC=C8F)C8=C7)=C(C(NS(=O)(C9=CC([N+]([O-])=O)=C(C=C9)NC[C@@H]%10CC[C@@](O)(CC%10)C)=O)=O)C=C6
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Bcl-2-IN-5 Related Classifications
HY-143873 Related Classifications
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