1. Apoptosis
  2. Bcl-2 Family
  3. Bcl-2-IN-5

Bcl-2-IN-5 

Cat. No.: HY-143873
Handling Instructions

Bcl-2-IN-5 is a BCL-2 inhibitor with IC50s of 0.12 nM, 0.14 nM and 0.22 nM for Bcl-2 wild type, Bcl-2 D103Y and Bcl-2 G101V, respectively. Bcl-2-IN-5 inhibits the cell growth with IC50 values of 0.2 nM and 0.44 nM for Bcl 2-G101V knock-in RS4; 11 and RS4; 11 cells, respectively (WO2021208963A1; Example 155).

For research use only. We do not sell to patients.

Bcl-2-IN-5 Chemical Structure

Bcl-2-IN-5 Chemical Structure

CAS No. : 2728752-20-1

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Description

Bcl-2-IN-5 is a BCL-2 inhibitor with IC50s of 0.12 nM, 0.14 nM and 0.22 nM for Bcl-2 wild type, Bcl-2 D103Y and Bcl-2 G101V, respectively. Bcl-2-IN-5 inhibits the cell growth with IC50 values of 0.2 nM and 0.44 nM for Bcl 2-G101V knock-in RS4; 11 and RS4; 11 cells, respectively (WO2021208963A1; Example 155)[1].

IC50 & Target[1]

Bcl-2

0.12 nM (IC50)

Bcl-2 D103Y

0.14 nM (IC50)

Bcl-2 G101V

0.22 nM (IC50)

Molecular Weight

1015.20

Formula

C55H63FN8O8S

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Bcl-2-IN-5
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