2728752-20-1
Chemical Structure
Bcl-2-IN-5
- CAS No.: 2728752-20-1
- Formula:C55H63FN8O8S
- Molecular Weight:1015.20
IUPAC Name: 2-((3-fluoro-1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-N-((4-((((1r,4r)-4-hydroxy-4-methylcyclohexyl)methyl)amino)-3-nitrophenyl)sulfonyl)-4-(6-((R)-2-(2-isopropylphenyl)-4-(4-methoxybenzyl)piperazin-1-yl)-2-azaspiro[3.3]heptan-2-yl)benzamide
InChIKey: DDYYYKLOAZDKFR-FOURAMJMSA-N
SMILES: COC(C=C1)=CC=C1CN(CC2)C[C@](C3=C(C=CC=C3)C(C)C)([H])N2C(C4)CC4(C5)CN5C6=CC(OC7=CN=C(NC=C8F)C8=C7)=C(C(NS(=O)(C9=CC([N+]([O-])=O)=C(C=C9)NC[C@@H]%10CC[C@@](O)(CC%10)C)=O)=O)C=C6
Biological Activity: Bcl-2-IN-5 is a BCL-2 inhibitor with IC50s of 0.12 nM, 0.14 nM and 0.22 nM for Bcl-2 wild type, Bcl-2 D103Y and Bcl-2 G101V, respectively. Bcl-2-IN-5 inhibits the cell growth with IC50 values of 0.2 nM and 0.44 nM for Bcl 2-G101V knock-in RS4; 11 and RS4; 11 cells, respectively (WO2021208963A1; Example 155)[1].
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Bcl-2-IN-5 | Bcl-2-IN-5 is a BCL-2 inhibitor with IC50s of 0.12 nM, 0.14 nM and 0.22 nM for Bcl-2 wild type, Bcl-2 D103Y and Bcl-2 G101V, respectively. Bcl-2-IN-5 inhibits the cell growth with IC50 values of 0.2 nM and 0.44 nM for Bcl 2-G101V knock-in RS4; 11 and RS4; 11 cells, respectively (WO2021208963A1; Example 155). | |||||||||||||||||||||
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Keywords
