1. Vitamin D Related
    Apoptosis
  2. VD/VDR
    Apoptosis
  3. VDR agonist 1

VDR agonist 1 

Cat. No.: HY-114310
Handling Instructions

VDR agonist 1 (compound 28) is a nonsteroidal Vitamin D receptor (VDR) agonist, with an IC50 of 690 nM in MCF-7 cells. VDR agonist 1 arrests the cell cycle through the up-regulation of p21 and p27, promotes apoptosis by increasing the expression of BAX and decrease the expression of Bcl-2.

For research use only. We do not sell to patients.

VDR agonist 1 Chemical Structure

VDR agonist 1 Chemical Structure

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Description

VDR agonist 1 (compound 28) is a nonsteroidal Vitamin D receptor (VDR) agonist, with an IC50 of 690 nM in MCF-7 cells. VDR agonist 1 arrests the cell cycle through the up-regulation of p21 and p27, promotes apoptosis by increasing the expression of BAX and decrease the expression of Bcl-2[1].

IC50 & Target

IC50: 690 nM (VDR in MCF-7 cells)[1].

Molecular Weight

509.77

Formula

C₃₂H₅₁N₃O₂

SMILES

O=C(C1=CC(C(CC)(C2=CC=C(/C=C/C(O)(CC)CC)C(C)=C2)CC)=CN1CC)NCCN(CC)CC

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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This equation is commonly abbreviated as: C1V1 = C2V2

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C1   V1   C2   V2

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Product Name:
VDR agonist 1
Cat. No.:
HY-114310
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