2269494-43-9
Chemical Structure
VDR agonist 1
- CAS No.: 2269494-43-9
- Formula:C32H51N3O2
- Molecular Weight:509.77
IUPAC Name: (E)-N-(2-(diethylamino)ethyl)-1-ethyl-4-(3-(4-(3-ethyl-3-hydroxypent-1-en-1-yl)-3-methylphenyl)pentan-3-yl)-1H-pyrrole-2-carboxamide
InChIKey: YRAFHBIJNFTEIJ-VHEBQXMUSA-N
SMILES: O=C(C1=CC(C(CC)(C2=CC=C(/C=C/C(O)(CC)CC)C(C)=C2)CC)=CN1CC)NCCN(CC)CC
Biological Activity: VDR agonist 1 (compound 28) is a nonsteroidal Vitamin D receptor (VDR) agonist, with an IC50 of 690 nM in MCF-7 cells. VDR agonist 1 arrests the cell cycle through the up-regulation of p21 and p27, promotes apoptosis by increasing the expression of BAX and decrease the expression of Bcl-2[1].
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VDR agonist 1 | VDR agonist 1 (compound 28) is a nonsteroidal Vitamin D receptor (VDR) agonist, with an IC50 of 690 nM in MCF-7 cells. VDR agonist 1 arrests the cell cycle through the up-regulation of p21 and p27, promotes apoptosis by increasing the expression of BAX and decrease the expression of Bcl-2. | |||||||||||||||||||||
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Keywords
